6FVX

26S proteasome, s5 state

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0000502	cellular_component	proteasome complex
1	0004175	molecular_function	endopeptidase activity
1	0004298	molecular_function	threonine-type endopeptidase activity
1	0005515	molecular_function	protein binding
1	0005634	cellular_component	nucleus
1	0005737	cellular_component	cytoplasm
1	0005829	cellular_component	cytosol
1	0005839	cellular_component	proteasome core complex
1	0006508	biological_process	proteolysis
1	0008233	molecular_function	peptidase activity
1	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
1	0016787	molecular_function	hydrolase activity
1	0019774	cellular_component	proteasome core complex, beta-subunit complex
1	0034515	cellular_component	proteasome storage granule
1	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
1	0051603	biological_process	proteolysis involved in protein catabolic process
2	0004298	molecular_function	threonine-type endopeptidase activity
2	0005839	cellular_component	proteasome core complex
2	0051603	biological_process	proteolysis involved in protein catabolic process
3	0000502	cellular_component	proteasome complex
3	0005515	molecular_function	protein binding
3	0005634	cellular_component	nucleus
3	0005737	cellular_component	cytoplasm
3	0005829	cellular_component	cytosol
3	0005839	cellular_component	proteasome core complex
3	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
3	0019774	cellular_component	proteasome core complex, beta-subunit complex
3	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
3	0051603	biological_process	proteolysis involved in protein catabolic process
3	0061133	molecular_function	endopeptidase activator activity
4	0000502	cellular_component	proteasome complex
4	0005515	molecular_function	protein binding
4	0005634	cellular_component	nucleus
4	0005737	cellular_component	cytoplasm
4	0005789	cellular_component	endoplasmic reticulum membrane
4	0005829	cellular_component	cytosol
4	0005839	cellular_component	proteasome core complex
4	0010498	biological_process	proteasomal protein catabolic process
4	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
4	0019774	cellular_component	proteasome core complex, beta-subunit complex
4	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
4	0051603	biological_process	proteolysis involved in protein catabolic process
4	0061133	molecular_function	endopeptidase activator activity
5	0004298	molecular_function	threonine-type endopeptidase activity
5	0005839	cellular_component	proteasome core complex
5	0051603	biological_process	proteolysis involved in protein catabolic process
6	0000502	cellular_component	proteasome complex
6	0003674	molecular_function	molecular_function
6	0005515	molecular_function	protein binding
6	0005634	cellular_component	nucleus
6	0005737	cellular_component	cytoplasm
6	0005829	cellular_component	cytosol
6	0005839	cellular_component	proteasome core complex
6	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
6	0019774	cellular_component	proteasome core complex, beta-subunit complex
6	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
6	0051603	biological_process	proteolysis involved in protein catabolic process
7	0005839	cellular_component	proteasome core complex
7	0051603	biological_process	proteolysis involved in protein catabolic process
A	0000502	cellular_component	proteasome complex
A	0003674	molecular_function	molecular_function
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0005839	cellular_component	proteasome core complex
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0051603	biological_process	proteolysis involved in protein catabolic process
B	0000502	cellular_component	proteasome complex
B	0003674	molecular_function	molecular_function
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005839	cellular_component	proteasome core complex
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0034515	cellular_component	proteasome storage granule
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0051603	biological_process	proteolysis involved in protein catabolic process
C	0000502	cellular_component	proteasome complex
C	0003674	molecular_function	molecular_function
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005839	cellular_component	proteasome core complex
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
C	0019773	cellular_component	proteasome core complex, alpha-subunit complex
C	0034515	cellular_component	proteasome storage granule
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0051603	biological_process	proteolysis involved in protein catabolic process
C	0080129	biological_process	proteasome core complex assembly
D	0000502	cellular_component	proteasome complex
D	0003674	molecular_function	molecular_function
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005839	cellular_component	proteasome core complex
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0034515	cellular_component	proteasome storage granule
D	0042175	cellular_component	nuclear outer membrane-endoplasmic reticulum membrane network
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0051603	biological_process	proteolysis involved in protein catabolic process
E	0000502	cellular_component	proteasome complex
E	0003674	molecular_function	molecular_function
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005839	cellular_component	proteasome core complex
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
E	0019773	cellular_component	proteasome core complex, alpha-subunit complex
E	0034515	cellular_component	proteasome storage granule
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0051603	biological_process	proteolysis involved in protein catabolic process
F	0000502	cellular_component	proteasome complex
F	0003674	molecular_function	molecular_function
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005839	cellular_component	proteasome core complex
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0034515	cellular_component	proteasome storage granule
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0051603	biological_process	proteolysis involved in protein catabolic process
G	0005839	cellular_component	proteasome core complex
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0051603	biological_process	proteolysis involved in protein catabolic process
H	0000166	molecular_function	nucleotide binding
H	0000502	cellular_component	proteasome complex
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
H	0008540	cellular_component	proteasome regulatory particle, base subcomplex
H	0010498	biological_process	proteasomal protein catabolic process
H	0010604	biological_process	positive regulation of macromolecule metabolic process
H	0016887	molecular_function	ATP hydrolysis activity
H	0031625	molecular_function	ubiquitin protein ligase binding
H	0036402	molecular_function	proteasome-activating activity
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0045732	biological_process	positive regulation of protein catabolic process
H	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
H	0070682	biological_process	proteasome regulatory particle assembly
H	0080090	biological_process	regulation of primary metabolic process
I	0005524	molecular_function	ATP binding
I	0016887	molecular_function	ATP hydrolysis activity
J	0000166	molecular_function	nucleotide binding
J	0000502	cellular_component	proteasome complex
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0006289	biological_process	nucleotide-excision repair
J	0006338	biological_process	chromatin remodeling
J	0008540	cellular_component	proteasome regulatory particle, base subcomplex
J	0010498	biological_process	proteasomal protein catabolic process
J	0010604	biological_process	positive regulation of macromolecule metabolic process
J	0016887	molecular_function	ATP hydrolysis activity
J	0019904	molecular_function	protein domain specific binding
J	0031625	molecular_function	ubiquitin protein ligase binding
J	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
J	0034515	cellular_component	proteasome storage granule
J	0036402	molecular_function	proteasome-activating activity
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
J	0070651	biological_process	nonfunctional rRNA decay
J	0070682	biological_process	proteasome regulatory particle assembly
J	0080090	biological_process	regulation of primary metabolic process
K	0000166	molecular_function	nucleotide binding
K	0000502	cellular_component	proteasome complex
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0006511	biological_process	ubiquitin-dependent protein catabolic process
K	0008540	cellular_component	proteasome regulatory particle, base subcomplex
K	0010498	biological_process	proteasomal protein catabolic process
K	0010604	biological_process	positive regulation of macromolecule metabolic process
K	0016887	molecular_function	ATP hydrolysis activity
K	0036402	molecular_function	proteasome-activating activity
K	0042802	molecular_function	identical protein binding
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
K	0070682	biological_process	proteasome regulatory particle assembly
K	0080090	biological_process	regulation of primary metabolic process
L	0005524	molecular_function	ATP binding
L	0016887	molecular_function	ATP hydrolysis activity
M	0000166	molecular_function	nucleotide binding
M	0000502	cellular_component	proteasome complex
M	0005515	molecular_function	protein binding
M	0005524	molecular_function	ATP binding
M	0005634	cellular_component	nucleus
M	0005737	cellular_component	cytoplasm
M	0006511	biological_process	ubiquitin-dependent protein catabolic process
M	0008540	cellular_component	proteasome regulatory particle, base subcomplex
M	0010498	biological_process	proteasomal protein catabolic process
M	0010604	biological_process	positive regulation of macromolecule metabolic process
M	0016887	molecular_function	ATP hydrolysis activity
M	0036402	molecular_function	proteasome-activating activity
M	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
M	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
M	0070682	biological_process	proteasome regulatory particle assembly
M	0080090	biological_process	regulation of primary metabolic process
N	0000502	cellular_component	proteasome complex
N	0004175	molecular_function	endopeptidase activity
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0006511	biological_process	ubiquitin-dependent protein catabolic process
N	0008540	cellular_component	proteasome regulatory particle, base subcomplex
N	0030234	molecular_function	enzyme regulator activity
N	0031625	molecular_function	ubiquitin protein ligase binding
N	0034515	cellular_component	proteasome storage granule
N	0042176	biological_process	regulation of protein catabolic process
N	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
N	0043248	biological_process	proteasome assembly
O	0000502	cellular_component	proteasome complex
O	0005198	molecular_function	structural molecule activity
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005829	cellular_component	cytosol
O	0006511	biological_process	ubiquitin-dependent protein catabolic process
O	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
O	0034515	cellular_component	proteasome storage granule
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	0043248	biological_process	proteasome assembly
P	0000338	biological_process	protein deneddylation
P	0000502	cellular_component	proteasome complex
P	0005515	molecular_function	protein binding
P	0005634	cellular_component	nucleus
P	0005737	cellular_component	cytoplasm
P	0008180	cellular_component	COP9 signalosome
P	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
P	0034515	cellular_component	proteasome storage granule
P	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Q	0000502	cellular_component	proteasome complex
Q	0005198	molecular_function	structural molecule activity
Q	0005515	molecular_function	protein binding
Q	0006511	biological_process	ubiquitin-dependent protein catabolic process
Q	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
Q	0034515	cellular_component	proteasome storage granule
Q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Q	0043248	biological_process	proteasome assembly
R	0000502	cellular_component	proteasome complex
R	0005198	molecular_function	structural molecule activity
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005838	cellular_component	proteasome regulatory particle
R	0006511	biological_process	ubiquitin-dependent protein catabolic process
R	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
R	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
S	0000502	cellular_component	proteasome complex
S	0003674	molecular_function	molecular_function
S	0005515	molecular_function	protein binding
S	0006511	biological_process	ubiquitin-dependent protein catabolic process
S	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
S	0030234	molecular_function	enzyme regulator activity
S	0042176	biological_process	regulation of protein catabolic process
S	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
T	0000502	cellular_component	proteasome complex
T	0003674	molecular_function	molecular_function
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005838	cellular_component	proteasome regulatory particle
T	0006508	biological_process	proteolysis
T	0006511	biological_process	ubiquitin-dependent protein catabolic process
T	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
T	0034515	cellular_component	proteasome storage granule
T	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
U	0000502	cellular_component	proteasome complex
U	0005515	molecular_function	protein binding
U	0005838	cellular_component	proteasome regulatory particle
U	0006511	biological_process	ubiquitin-dependent protein catabolic process
U	0008233	molecular_function	peptidase activity
U	0008237	molecular_function	metallopeptidase activity
U	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
U	0034515	cellular_component	proteasome storage granule
U	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
V	0000266	biological_process	mitochondrial fission
V	0000502	cellular_component	proteasome complex
V	0004843	molecular_function	cysteine-type deubiquitinase activity
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005739	cellular_component	mitochondrion
V	0005829	cellular_component	cytosol
V	0006508	biological_process	proteolysis
V	0008233	molecular_function	peptidase activity
V	0008234	molecular_function	cysteine-type peptidase activity
V	0008237	molecular_function	metallopeptidase activity
V	0008270	molecular_function	zinc ion binding
V	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
V	0016559	biological_process	peroxisome fission
V	0016579	biological_process	protein deubiquitination
V	0016787	molecular_function	hydrolase activity
V	0032436	biological_process	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
V	0034515	cellular_component	proteasome storage granule
V	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
V	0043248	biological_process	proteasome assembly
V	0046872	molecular_function	metal ion binding
V	0070628	molecular_function	proteasome binding
V	0140492	molecular_function	metal-dependent deubiquitinase activity
V	1902906	biological_process	proteasome storage granule assembly
X	0005634	cellular_component	nucleus
X	0005737	cellular_component	cytoplasm
Y	0000502	cellular_component	proteasome complex
Y	0000724	biological_process	double-strand break repair via homologous recombination
Y	0003674	molecular_function	molecular_function
Y	0005515	molecular_function	protein binding
Y	0005829	cellular_component	cytosol
Y	0006406	biological_process	mRNA export from nucleus
Y	0006457	biological_process	protein folding
Y	0006511	biological_process	ubiquitin-dependent protein catabolic process
Y	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
Y	0030447	biological_process	filamentous growth
Y	0034515	cellular_component	proteasome storage granule
Y	0035753	biological_process	maintenance of DNA trinucleotide repeats
Y	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Y	0043248	biological_process	proteasome assembly
Y	0044183	molecular_function	protein folding chaperone
Y	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Y	0051726	biological_process	regulation of cell cycle
Y	0060090	molecular_function	molecular adaptor activity
Y	0070390	cellular_component	transcription export complex 2
Y	0072742	biological_process	SAGA complex localization to transcription regulatory region
Z	0000502	cellular_component	proteasome complex
Z	0004175	molecular_function	endopeptidase activity
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005737	cellular_component	cytoplasm
Z	0005783	cellular_component	endoplasmic reticulum
Z	0006511	biological_process	ubiquitin-dependent protein catabolic process
Z	0008540	cellular_component	proteasome regulatory particle, base subcomplex
Z	0030234	molecular_function	enzyme regulator activity
Z	0030674	molecular_function	protein-macromolecule adaptor activity
Z	0034515	cellular_component	proteasome storage granule
Z	0042176	biological_process	regulation of protein catabolic process
Z	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
a	0000502	cellular_component	proteasome complex
a	0003674	molecular_function	molecular_function
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0005737	cellular_component	cytoplasm
a	0005739	cellular_component	mitochondrion
a	0005829	cellular_component	cytosol
a	0005839	cellular_component	proteasome core complex
a	0006511	biological_process	ubiquitin-dependent protein catabolic process
a	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
a	0019773	cellular_component	proteasome core complex, alpha-subunit complex
a	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
a	0051603	biological_process	proteolysis involved in protein catabolic process
b	0000502	cellular_component	proteasome complex
b	0003674	molecular_function	molecular_function
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005737	cellular_component	cytoplasm
b	0005839	cellular_component	proteasome core complex
b	0006511	biological_process	ubiquitin-dependent protein catabolic process
b	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
b	0019773	cellular_component	proteasome core complex, alpha-subunit complex
b	0034515	cellular_component	proteasome storage granule
b	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
b	0051603	biological_process	proteolysis involved in protein catabolic process
c	0000502	cellular_component	proteasome complex
c	0003674	molecular_function	molecular_function
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0005737	cellular_component	cytoplasm
c	0005829	cellular_component	cytosol
c	0005839	cellular_component	proteasome core complex
c	0006511	biological_process	ubiquitin-dependent protein catabolic process
c	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
c	0019773	cellular_component	proteasome core complex, alpha-subunit complex
c	0034515	cellular_component	proteasome storage granule
c	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
c	0051603	biological_process	proteolysis involved in protein catabolic process
c	0080129	biological_process	proteasome core complex assembly
d	0000502	cellular_component	proteasome complex
d	0003674	molecular_function	molecular_function
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005737	cellular_component	cytoplasm
d	0005739	cellular_component	mitochondrion
d	0005839	cellular_component	proteasome core complex
d	0006511	biological_process	ubiquitin-dependent protein catabolic process
d	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
d	0019773	cellular_component	proteasome core complex, alpha-subunit complex
d	0034515	cellular_component	proteasome storage granule
d	0042175	cellular_component	nuclear outer membrane-endoplasmic reticulum membrane network
d	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
d	0051603	biological_process	proteolysis involved in protein catabolic process
e	0000502	cellular_component	proteasome complex
e	0003674	molecular_function	molecular_function
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005737	cellular_component	cytoplasm
e	0005839	cellular_component	proteasome core complex
e	0006511	biological_process	ubiquitin-dependent protein catabolic process
e	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
e	0019773	cellular_component	proteasome core complex, alpha-subunit complex
e	0034515	cellular_component	proteasome storage granule
e	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
e	0051603	biological_process	proteolysis involved in protein catabolic process
f	0000502	cellular_component	proteasome complex
f	0003674	molecular_function	molecular_function
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0005737	cellular_component	cytoplasm
f	0005839	cellular_component	proteasome core complex
f	0006511	biological_process	ubiquitin-dependent protein catabolic process
f	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
f	0019773	cellular_component	proteasome core complex, alpha-subunit complex
f	0034515	cellular_component	proteasome storage granule
f	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
f	0051603	biological_process	proteolysis involved in protein catabolic process
g	0005839	cellular_component	proteasome core complex
g	0006511	biological_process	ubiquitin-dependent protein catabolic process
g	0019773	cellular_component	proteasome core complex, alpha-subunit complex
g	0051603	biological_process	proteolysis involved in protein catabolic process
h	0000502	cellular_component	proteasome complex
h	0004175	molecular_function	endopeptidase activity
h	0004298	molecular_function	threonine-type endopeptidase activity
h	0005515	molecular_function	protein binding
h	0005634	cellular_component	nucleus
h	0005737	cellular_component	cytoplasm
h	0005829	cellular_component	cytosol
h	0005839	cellular_component	proteasome core complex
h	0006508	biological_process	proteolysis
h	0008233	molecular_function	peptidase activity
h	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
h	0016787	molecular_function	hydrolase activity
h	0019774	cellular_component	proteasome core complex, beta-subunit complex
h	0034515	cellular_component	proteasome storage granule
h	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
h	0051603	biological_process	proteolysis involved in protein catabolic process
i	0004298	molecular_function	threonine-type endopeptidase activity
i	0005839	cellular_component	proteasome core complex
i	0051603	biological_process	proteolysis involved in protein catabolic process
j	0000502	cellular_component	proteasome complex
j	0005515	molecular_function	protein binding
j	0005634	cellular_component	nucleus
j	0005737	cellular_component	cytoplasm
j	0005829	cellular_component	cytosol
j	0005839	cellular_component	proteasome core complex
j	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
j	0019774	cellular_component	proteasome core complex, beta-subunit complex
j	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
j	0051603	biological_process	proteolysis involved in protein catabolic process
j	0061133	molecular_function	endopeptidase activator activity
k	0000502	cellular_component	proteasome complex
k	0005515	molecular_function	protein binding
k	0005634	cellular_component	nucleus
k	0005737	cellular_component	cytoplasm
k	0005789	cellular_component	endoplasmic reticulum membrane
k	0005829	cellular_component	cytosol
k	0005839	cellular_component	proteasome core complex
k	0010498	biological_process	proteasomal protein catabolic process
k	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
k	0019774	cellular_component	proteasome core complex, beta-subunit complex
k	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
k	0051603	biological_process	proteolysis involved in protein catabolic process
k	0061133	molecular_function	endopeptidase activator activity
l	0004298	molecular_function	threonine-type endopeptidase activity
l	0005839	cellular_component	proteasome core complex
l	0051603	biological_process	proteolysis involved in protein catabolic process
m	0000502	cellular_component	proteasome complex
m	0003674	molecular_function	molecular_function
m	0005515	molecular_function	protein binding
m	0005634	cellular_component	nucleus
m	0005737	cellular_component	cytoplasm
m	0005829	cellular_component	cytosol
m	0005839	cellular_component	proteasome core complex
m	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
m	0019774	cellular_component	proteasome core complex, beta-subunit complex
m	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
m	0051603	biological_process	proteolysis involved in protein catabolic process
n	0005839	cellular_component	proteasome core complex
n	0051603	biological_process	proteolysis involved in protein catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	binding site for residue ATP H 501

Chain	Residue
H	ASP210
H	ARG261
H	GLU310
H	ASN356
H	ILE388
H	HIS392
H	GLY416
H	ALA417
H	MG502
I	ASP314
I	ARG340
H	GLY212
I	ARG343
H	PRO252
H	GLY253
H	THR254
H	GLY255
H	LYS256
H	THR257
H	LEU258

---

site_id	AC2
Number of Residues	2
Details	binding site for residue MG H 502

Chain	Residue
H	THR257
H	ATP501

---

site_id	AC3
Number of Residues	18
Details	binding site for residue ATP I 501

Chain	Residue
I	GLU179
I	ASP183
I	ILE184
I	GLY185
I	LEU187
I	GLY226
I	THR227
I	GLY228
I	LYS229
I	THR230
I	LEU231
I	ILE361
I	ILE364
I	HIS365
I	GLY389
I	GLN393
I	MG502
J	ARG306

---

site_id	AC4
Number of Residues	2
Details	binding site for residue MG I 502

Chain	Residue
I	THR230
I	ATP501

---

site_id	AC5
Number of Residues	16
Details	binding site for residue ATP K 501

Chain	Residue
K	ASP173
K	VAL174
K	GLY175
K	GLY176
K	PRO215
K	THR217
K	GLY218
K	LYS219
K	THR220
K	MET221
K	GLU273
K	ILE352
K	GLY380
K	ALA381
K	MG502
L	ARG339

---

site_id	AC6
Number of Residues	2
Details	binding site for residue MG K 502

Chain	Residue
K	THR220
K	ATP501

---

site_id	AC7
Number of Residues	18
Details	binding site for residue ATP L 501

Chain	Residue
L	GLY182
L	GLY184
L	LEU186
L	PRO224
L	GLY225
L	THR226
L	GLY227
L	LYS228
L	THR229
L	LEU230
L	GLU282
L	ASN328
L	HIS364
L	GLY388
L	ALA389
L	MG502
M	ARG339
M	ARG342

---

site_id	AC8
Number of Residues	2
Details	binding site for residue MG L 502

Chain	Residue
L	THR229
L	ATP501

---

site_id	AC9
Number of Residues	15
Details	binding site for residue ATP M 501

Chain	Residue
H	ASP341
H	ALA364
H	ARG367
M	GLY184
M	PRO224
M	GLY225
M	THR226
M	GLY227
M	LYS228
M	THR229
M	LEU230
M	ASN328
M	ILE360
M	HIS364
M	MG502

---

site_id	AD1
Number of Residues	2
Details	binding site for residue MG M 502

Chain	Residue
M	THR229
M	ATP501

---

site_id	AD2
Number of Residues	12
Details	binding site for residue ADP J 501

Chain	Residue
J	GLY194
J	LYS195
J	THR196
J	LEU197
J	ARG200
J	ILE327
J	HIS331
J	GLY355
J	LYS359
J	MG502
J	GLY192
J	THR193

---

site_id	AD3
Number of Residues	2
Details	binding site for residue MG J 502

Chain	Residue
J	THR196
J	ADP501

---

Functional Information from PROSITE/UniProt

site_id	PS00387
Number of Residues	7
Details	PPASE Inorganic pyrophosphatase signature. DDDEIDV

Chain	Residue	Details
U	ASP243-VAL249

---

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdsrtTiFSPeGRlyQVEYAleS

Chain	Residue	Details
c	TYR6-SER28
d	TYR4-ALA26
b	TYR5-ALA27
f	TYR6-ALA28
a	TYR12-ALA34
g	TYR8-ALA30
e	TYR8-ALA30

---

site_id	PS00674
Number of Residues	19
Details	AAA AAA-protein family signature. IkIImATNrldiLDpALl.R

Chain	Residue	Details
J	ILE288-ARG306
K	VAL312-ARG330
L	THR321-ARG339
I	VAL322-ARG340
M	VAL321-ARG339
H	ILE349-ARG367

---

site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. IGImAsdGIVLAAErkvtstlleqdtste.KlyklndkiavavaGltAD

Chain	Residue	Details
c	ILE36-ASP83
d	VAL34-ASP81
6	LEU21-ASP68
7	ILE45-ASP92
k	LEU5-ASP52
h	MET13-ASP60
l	LEU79-ASP126
j	VAL13-ASP59
i	VAL33-ASP80

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	30
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	156
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	62
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17287358","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17330950","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	6
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"9087403","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	9
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	185
Details	Domain: {"description":"VWFA","evidences":[{"source":"PROSITE-ProRule","id":"PRU00219","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	270
Details	Domain: {"description":"MPN","evidences":[{"source":"PROSITE-ProRule","id":"PRU01182","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	13
Details	Motif: {"description":"JAMM motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU01182","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01182","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	1038
Details	Domain: {"description":"PCI","evidences":[{"source":"PROSITE-ProRule","id":"PRU01185","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"15665377","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"15665377","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	65
Details	Repeat: {"description":"PC 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	74
Details	Repeat: {"description":"PC 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	68
Details	Repeat: {"description":"PC 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	74
Details	Repeat: {"description":"PC 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	65
Details	Repeat: {"description":"PC 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	66
Details	Repeat: {"description":"PC 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	66
Details	Repeat: {"description":"PC 7"}

Chain

Residue

Details

---

site_id	SWS_FT_FI27
Number of Residues	29
Details	Compositional bias: {"description":"Low complexity","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI28
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI29
Number of Residues	34
Details	Repeat: {"description":"PC 8"}

Chain

Residue

Details

---

site_id	SWS_FT_FI30
Number of Residues	37
Details	Repeat: {"description":"PC 9"}

Chain

Residue

Details

---

site_id	SWS_FT_FI31
Number of Residues	36
Details	Repeat: {"description":"PC 10"}

Chain

Residue

Details

---

site_id	SWS_FT_FI32
Number of Residues	9
Details	Compositional bias: {"description":"Basic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI33
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI34
Number of Residues	2
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"12504901","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI35
Number of Residues	1
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"12504901","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI36
Number of Residues	33
Details	Repeat: {"description":"TPR"}

Chain

Residue

Details

---

site_id	SWS_FT_FI37
Number of Residues	35
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI38
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19779198","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI39
Number of Residues	1
Details	Modified residue: {"description":"N-acetylthreonine","evidences":[{"source":"PubMed","id":"12504901","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	8
Details	M-CSA 177

Chain	Residue	Details
I	THR53	covalently attached, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor
I	LEU69	activator, steric locator
I	LEU71	activator
I	PHE85	activator, electrostatic stabiliser
I	ILE99	electrostatic stabiliser
I	TYR181	activator, electrostatic stabiliser
I	GLY218	activator, steric locator
I	LEU221	activator, electrostatic stabiliser

---

site_id	MCSA2
Number of Residues	8
Details	M-CSA 177

Chain	Residue	Details
W	MET1	covalently attached, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor
W	ARG17	activator, steric locator
W	GLY19	activator
W	VAL33	activator, electrostatic stabiliser
W	ASN47	electrostatic stabiliser
W	ALA129	activator, electrostatic stabiliser
W	GLU166	activator, steric locator
W	SER169	activator, electrostatic stabiliser

---