6FVW

26S proteasome, s4 state

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0000502	cellular_component	proteasome complex
1	0004175	molecular_function	endopeptidase activity
1	0004298	molecular_function	threonine-type endopeptidase activity
1	0005634	cellular_component	nucleus
1	0005737	cellular_component	cytoplasm
1	0005829	cellular_component	cytosol
1	0005839	cellular_component	proteasome core complex
1	0006508	biological_process	proteolysis
1	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
1	0019774	cellular_component	proteasome core complex, beta-subunit complex
1	0034515	cellular_component	proteasome storage granule
1	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
1	0051603	biological_process	proteolysis involved in protein catabolic process
2	0004298	molecular_function	threonine-type endopeptidase activity
2	0005839	cellular_component	proteasome core complex
2	0051603	biological_process	proteolysis involved in protein catabolic process
3	0000502	cellular_component	proteasome complex
3	0005515	molecular_function	protein binding
3	0005634	cellular_component	nucleus
3	0005737	cellular_component	cytoplasm
3	0005829	cellular_component	cytosol
3	0005839	cellular_component	proteasome core complex
3	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
3	0019774	cellular_component	proteasome core complex, beta-subunit complex
3	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
3	0051603	biological_process	proteolysis involved in protein catabolic process
3	0061133	molecular_function	endopeptidase activator activity
4	0000502	cellular_component	proteasome complex
4	0005515	molecular_function	protein binding
4	0005634	cellular_component	nucleus
4	0005737	cellular_component	cytoplasm
4	0005789	cellular_component	endoplasmic reticulum membrane
4	0005829	cellular_component	cytosol
4	0005839	cellular_component	proteasome core complex
4	0010498	biological_process	proteasomal protein catabolic process
4	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
4	0019774	cellular_component	proteasome core complex, beta-subunit complex
4	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
4	0051603	biological_process	proteolysis involved in protein catabolic process
4	0061133	molecular_function	endopeptidase activator activity
5	0004298	molecular_function	threonine-type endopeptidase activity
5	0005839	cellular_component	proteasome core complex
5	0051603	biological_process	proteolysis involved in protein catabolic process
6	0000502	cellular_component	proteasome complex
6	0003674	molecular_function	molecular_function
6	0005515	molecular_function	protein binding
6	0005634	cellular_component	nucleus
6	0005737	cellular_component	cytoplasm
6	0005829	cellular_component	cytosol
6	0005839	cellular_component	proteasome core complex
6	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
6	0019774	cellular_component	proteasome core complex, beta-subunit complex
6	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
6	0051603	biological_process	proteolysis involved in protein catabolic process
7	0005839	cellular_component	proteasome core complex
7	0051603	biological_process	proteolysis involved in protein catabolic process
a	0000502	cellular_component	proteasome complex
a	0003674	molecular_function	molecular_function
a	0005515	molecular_function	protein binding
a	0005634	cellular_component	nucleus
a	0005737	cellular_component	cytoplasm
a	0005739	cellular_component	mitochondrion
a	0005839	cellular_component	proteasome core complex
a	0006511	biological_process	ubiquitin-dependent protein catabolic process
a	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
a	0019773	cellular_component	proteasome core complex, alpha-subunit complex
a	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
a	0051603	biological_process	proteolysis involved in protein catabolic process
A	0000502	cellular_component	proteasome complex
A	0003674	molecular_function	molecular_function
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005839	cellular_component	proteasome core complex
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
A	0019773	cellular_component	proteasome core complex, alpha-subunit complex
A	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
A	0051603	biological_process	proteolysis involved in protein catabolic process
b	0000502	cellular_component	proteasome complex
b	0003674	molecular_function	molecular_function
b	0005515	molecular_function	protein binding
b	0005634	cellular_component	nucleus
b	0005737	cellular_component	cytoplasm
b	0005839	cellular_component	proteasome core complex
b	0006511	biological_process	ubiquitin-dependent protein catabolic process
b	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
b	0019773	cellular_component	proteasome core complex, alpha-subunit complex
b	0034515	cellular_component	proteasome storage granule
b	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
b	0051603	biological_process	proteolysis involved in protein catabolic process
B	0000502	cellular_component	proteasome complex
B	0003674	molecular_function	molecular_function
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005839	cellular_component	proteasome core complex
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
B	0019773	cellular_component	proteasome core complex, alpha-subunit complex
B	0034515	cellular_component	proteasome storage granule
B	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
B	0051603	biological_process	proteolysis involved in protein catabolic process
c	0000502	cellular_component	proteasome complex
c	0003674	molecular_function	molecular_function
c	0005515	molecular_function	protein binding
c	0005634	cellular_component	nucleus
c	0005737	cellular_component	cytoplasm
c	0005829	cellular_component	cytosol
c	0005839	cellular_component	proteasome core complex
c	0006511	biological_process	ubiquitin-dependent protein catabolic process
c	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
c	0019773	cellular_component	proteasome core complex, alpha-subunit complex
c	0034515	cellular_component	proteasome storage granule
c	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
c	0051603	biological_process	proteolysis involved in protein catabolic process
c	0080129	biological_process	proteasome core complex assembly
C	0000502	cellular_component	proteasome complex
C	0003674	molecular_function	molecular_function
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005839	cellular_component	proteasome core complex
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
C	0019773	cellular_component	proteasome core complex, alpha-subunit complex
C	0034515	cellular_component	proteasome storage granule
C	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
C	0051603	biological_process	proteolysis involved in protein catabolic process
C	0080129	biological_process	proteasome core complex assembly
d	0000502	cellular_component	proteasome complex
d	0003674	molecular_function	molecular_function
d	0005515	molecular_function	protein binding
d	0005634	cellular_component	nucleus
d	0005737	cellular_component	cytoplasm
d	0005739	cellular_component	mitochondrion
d	0005839	cellular_component	proteasome core complex
d	0006511	biological_process	ubiquitin-dependent protein catabolic process
d	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
d	0019773	cellular_component	proteasome core complex, alpha-subunit complex
d	0034515	cellular_component	proteasome storage granule
d	0042175	cellular_component	nuclear outer membrane-endoplasmic reticulum membrane network
d	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
d	0051603	biological_process	proteolysis involved in protein catabolic process
D	0000502	cellular_component	proteasome complex
D	0003674	molecular_function	molecular_function
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005839	cellular_component	proteasome core complex
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
D	0019773	cellular_component	proteasome core complex, alpha-subunit complex
D	0034515	cellular_component	proteasome storage granule
D	0042175	cellular_component	nuclear outer membrane-endoplasmic reticulum membrane network
D	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
D	0051603	biological_process	proteolysis involved in protein catabolic process
e	0000502	cellular_component	proteasome complex
e	0003674	molecular_function	molecular_function
e	0005515	molecular_function	protein binding
e	0005634	cellular_component	nucleus
e	0005737	cellular_component	cytoplasm
e	0005839	cellular_component	proteasome core complex
e	0006511	biological_process	ubiquitin-dependent protein catabolic process
e	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
e	0019773	cellular_component	proteasome core complex, alpha-subunit complex
e	0034515	cellular_component	proteasome storage granule
e	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
e	0051603	biological_process	proteolysis involved in protein catabolic process
E	0000502	cellular_component	proteasome complex
E	0003674	molecular_function	molecular_function
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005839	cellular_component	proteasome core complex
E	0006511	biological_process	ubiquitin-dependent protein catabolic process
E	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
E	0019773	cellular_component	proteasome core complex, alpha-subunit complex
E	0034515	cellular_component	proteasome storage granule
E	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
E	0051603	biological_process	proteolysis involved in protein catabolic process
f	0000502	cellular_component	proteasome complex
f	0003674	molecular_function	molecular_function
f	0005515	molecular_function	protein binding
f	0005634	cellular_component	nucleus
f	0005737	cellular_component	cytoplasm
f	0005839	cellular_component	proteasome core complex
f	0006511	biological_process	ubiquitin-dependent protein catabolic process
f	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
f	0019773	cellular_component	proteasome core complex, alpha-subunit complex
f	0034515	cellular_component	proteasome storage granule
f	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
f	0051603	biological_process	proteolysis involved in protein catabolic process
F	0000502	cellular_component	proteasome complex
F	0003674	molecular_function	molecular_function
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005839	cellular_component	proteasome core complex
F	0006511	biological_process	ubiquitin-dependent protein catabolic process
F	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
F	0019773	cellular_component	proteasome core complex, alpha-subunit complex
F	0034515	cellular_component	proteasome storage granule
F	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
F	0051603	biological_process	proteolysis involved in protein catabolic process
g	0005839	cellular_component	proteasome core complex
g	0006511	biological_process	ubiquitin-dependent protein catabolic process
g	0019773	cellular_component	proteasome core complex, alpha-subunit complex
g	0051603	biological_process	proteolysis involved in protein catabolic process
G	0005839	cellular_component	proteasome core complex
G	0006511	biological_process	ubiquitin-dependent protein catabolic process
G	0019773	cellular_component	proteasome core complex, alpha-subunit complex
G	0051603	biological_process	proteolysis involved in protein catabolic process
h	0000502	cellular_component	proteasome complex
h	0004175	molecular_function	endopeptidase activity
h	0004298	molecular_function	threonine-type endopeptidase activity
h	0005634	cellular_component	nucleus
h	0005737	cellular_component	cytoplasm
h	0005829	cellular_component	cytosol
h	0005839	cellular_component	proteasome core complex
h	0006508	biological_process	proteolysis
h	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
h	0019774	cellular_component	proteasome core complex, beta-subunit complex
h	0034515	cellular_component	proteasome storage granule
h	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
h	0051603	biological_process	proteolysis involved in protein catabolic process
H	0000502	cellular_component	proteasome complex
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0006511	biological_process	ubiquitin-dependent protein catabolic process
H	0008540	cellular_component	proteasome regulatory particle, base subcomplex
H	0010604	biological_process	positive regulation of macromolecule metabolic process
H	0016887	molecular_function	ATP hydrolysis activity
H	0031625	molecular_function	ubiquitin protein ligase binding
H	0036402	molecular_function	proteasome-activating activity
H	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
H	0045732	biological_process	positive regulation of protein catabolic process
H	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
H	0051173	biological_process	obsolete positive regulation of nitrogen compound metabolic process
H	0070682	biological_process	proteasome regulatory particle assembly
H	1901800	biological_process	positive regulation of proteasomal protein catabolic process
i	0004298	molecular_function	threonine-type endopeptidase activity
i	0005839	cellular_component	proteasome core complex
i	0051603	biological_process	proteolysis involved in protein catabolic process
I	0005524	molecular_function	ATP binding
I	0016887	molecular_function	ATP hydrolysis activity
j	0000502	cellular_component	proteasome complex
j	0005515	molecular_function	protein binding
j	0005634	cellular_component	nucleus
j	0005737	cellular_component	cytoplasm
j	0005829	cellular_component	cytosol
j	0005839	cellular_component	proteasome core complex
j	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
j	0019774	cellular_component	proteasome core complex, beta-subunit complex
j	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
j	0051603	biological_process	proteolysis involved in protein catabolic process
j	0061133	molecular_function	endopeptidase activator activity
J	0000502	cellular_component	proteasome complex
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0006289	biological_process	nucleotide-excision repair
J	0006338	biological_process	chromatin remodeling
J	0008540	cellular_component	proteasome regulatory particle, base subcomplex
J	0010604	biological_process	positive regulation of macromolecule metabolic process
J	0016887	molecular_function	ATP hydrolysis activity
J	0019904	molecular_function	protein domain specific binding
J	0031625	molecular_function	ubiquitin protein ligase binding
J	0032968	biological_process	positive regulation of transcription elongation by RNA polymerase II
J	0034515	cellular_component	proteasome storage granule
J	0036402	molecular_function	proteasome-activating activity
J	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
J	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
J	0051173	biological_process	obsolete positive regulation of nitrogen compound metabolic process
J	0070651	biological_process	nonfunctional rRNA decay
J	0070682	biological_process	proteasome regulatory particle assembly
J	1901800	biological_process	positive regulation of proteasomal protein catabolic process
k	0000502	cellular_component	proteasome complex
k	0005515	molecular_function	protein binding
k	0005634	cellular_component	nucleus
k	0005737	cellular_component	cytoplasm
k	0005789	cellular_component	endoplasmic reticulum membrane
k	0005829	cellular_component	cytosol
k	0005839	cellular_component	proteasome core complex
k	0010498	biological_process	proteasomal protein catabolic process
k	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
k	0019774	cellular_component	proteasome core complex, beta-subunit complex
k	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
k	0051603	biological_process	proteolysis involved in protein catabolic process
k	0061133	molecular_function	endopeptidase activator activity
K	0000502	cellular_component	proteasome complex
K	0005515	molecular_function	protein binding
K	0005524	molecular_function	ATP binding
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0006511	biological_process	ubiquitin-dependent protein catabolic process
K	0008540	cellular_component	proteasome regulatory particle, base subcomplex
K	0010604	biological_process	positive regulation of macromolecule metabolic process
K	0016887	molecular_function	ATP hydrolysis activity
K	0036402	molecular_function	proteasome-activating activity
K	0042802	molecular_function	identical protein binding
K	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
K	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
K	0051173	biological_process	obsolete positive regulation of nitrogen compound metabolic process
K	0070682	biological_process	proteasome regulatory particle assembly
K	1901800	biological_process	positive regulation of proteasomal protein catabolic process
l	0004298	molecular_function	threonine-type endopeptidase activity
l	0005839	cellular_component	proteasome core complex
l	0051603	biological_process	proteolysis involved in protein catabolic process
L	0005524	molecular_function	ATP binding
L	0016887	molecular_function	ATP hydrolysis activity
m	0000502	cellular_component	proteasome complex
m	0003674	molecular_function	molecular_function
m	0005515	molecular_function	protein binding
m	0005634	cellular_component	nucleus
m	0005737	cellular_component	cytoplasm
m	0005829	cellular_component	cytosol
m	0005839	cellular_component	proteasome core complex
m	0010499	biological_process	proteasomal ubiquitin-independent protein catabolic process
m	0019774	cellular_component	proteasome core complex, beta-subunit complex
m	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
m	0051603	biological_process	proteolysis involved in protein catabolic process
M	0000502	cellular_component	proteasome complex
M	0005515	molecular_function	protein binding
M	0005524	molecular_function	ATP binding
M	0005634	cellular_component	nucleus
M	0005737	cellular_component	cytoplasm
M	0006511	biological_process	ubiquitin-dependent protein catabolic process
M	0008540	cellular_component	proteasome regulatory particle, base subcomplex
M	0010604	biological_process	positive regulation of macromolecule metabolic process
M	0016887	molecular_function	ATP hydrolysis activity
M	0036402	molecular_function	proteasome-activating activity
M	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
M	0045899	biological_process	positive regulation of RNA polymerase II transcription preinitiation complex assembly
M	0051173	biological_process	obsolete positive regulation of nitrogen compound metabolic process
M	0070682	biological_process	proteasome regulatory particle assembly
M	1901800	biological_process	positive regulation of proteasomal protein catabolic process
n	0005839	cellular_component	proteasome core complex
n	0051603	biological_process	proteolysis involved in protein catabolic process
N	0000502	cellular_component	proteasome complex
N	0004175	molecular_function	endopeptidase activity
N	0005515	molecular_function	protein binding
N	0005634	cellular_component	nucleus
N	0006511	biological_process	ubiquitin-dependent protein catabolic process
N	0008540	cellular_component	proteasome regulatory particle, base subcomplex
N	0030234	molecular_function	enzyme regulator activity
N	0031625	molecular_function	ubiquitin protein ligase binding
N	0034515	cellular_component	proteasome storage granule
N	0042176	biological_process	regulation of protein catabolic process
N	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
N	0043248	biological_process	proteasome assembly
O	0000502	cellular_component	proteasome complex
O	0005198	molecular_function	structural molecule activity
O	0005515	molecular_function	protein binding
O	0005634	cellular_component	nucleus
O	0005829	cellular_component	cytosol
O	0006511	biological_process	ubiquitin-dependent protein catabolic process
O	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
O	0034515	cellular_component	proteasome storage granule
O	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
O	0043248	biological_process	proteasome assembly
P	0000338	biological_process	protein deneddylation
P	0000502	cellular_component	proteasome complex
P	0005515	molecular_function	protein binding
P	0005737	cellular_component	cytoplasm
P	0008180	cellular_component	COP9 signalosome
P	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
P	0034515	cellular_component	proteasome storage granule
P	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Q	0000502	cellular_component	proteasome complex
Q	0005198	molecular_function	structural molecule activity
Q	0005515	molecular_function	protein binding
Q	0006511	biological_process	ubiquitin-dependent protein catabolic process
Q	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
Q	0034515	cellular_component	proteasome storage granule
Q	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Q	0043248	biological_process	proteasome assembly
R	0000502	cellular_component	proteasome complex
R	0005198	molecular_function	structural molecule activity
R	0005515	molecular_function	protein binding
R	0005634	cellular_component	nucleus
R	0005838	cellular_component	proteasome regulatory particle
R	0006511	biological_process	ubiquitin-dependent protein catabolic process
R	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
R	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
S	0000502	cellular_component	proteasome complex
S	0003674	molecular_function	molecular_function
S	0005515	molecular_function	protein binding
S	0006511	biological_process	ubiquitin-dependent protein catabolic process
S	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
S	0030234	molecular_function	enzyme regulator activity
S	0042176	biological_process	regulation of protein catabolic process
S	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
T	0000502	cellular_component	proteasome complex
T	0003674	molecular_function	molecular_function
T	0005515	molecular_function	protein binding
T	0005634	cellular_component	nucleus
T	0005838	cellular_component	proteasome regulatory particle
T	0006508	biological_process	proteolysis
T	0006511	biological_process	ubiquitin-dependent protein catabolic process
T	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
T	0034515	cellular_component	proteasome storage granule
T	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
U	0000502	cellular_component	proteasome complex
U	0005515	molecular_function	protein binding
U	0005838	cellular_component	proteasome regulatory particle
U	0006511	biological_process	ubiquitin-dependent protein catabolic process
U	0008233	molecular_function	peptidase activity
U	0008237	molecular_function	metallopeptidase activity
U	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
U	0034515	cellular_component	proteasome storage granule
U	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
V	0000266	biological_process	mitochondrial fission
V	0000502	cellular_component	proteasome complex
V	0004843	molecular_function	cysteine-type deubiquitinase activity
V	0005515	molecular_function	protein binding
V	0005634	cellular_component	nucleus
V	0005739	cellular_component	mitochondrion
V	0005829	cellular_component	cytosol
V	0006508	biological_process	proteolysis
V	0008233	molecular_function	peptidase activity
V	0008234	molecular_function	cysteine-type peptidase activity
V	0008237	molecular_function	metallopeptidase activity
V	0008270	molecular_function	zinc ion binding
V	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
V	0016559	biological_process	peroxisome fission
V	0034515	cellular_component	proteasome storage granule
V	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
V	0043248	biological_process	proteasome assembly
V	0046872	molecular_function	metal ion binding
V	0070628	molecular_function	proteasome binding
V	0140492	molecular_function	metal-dependent deubiquitinase activity
V	1902906	biological_process	proteasome storage granule assembly
X	0005634	cellular_component	nucleus
X	0005737	cellular_component	cytoplasm
Y	0000502	cellular_component	proteasome complex
Y	0000724	biological_process	double-strand break repair via homologous recombination
Y	0003674	molecular_function	molecular_function
Y	0005515	molecular_function	protein binding
Y	0005829	cellular_component	cytosol
Y	0006406	biological_process	mRNA export from nucleus
Y	0006457	biological_process	protein folding
Y	0006511	biological_process	ubiquitin-dependent protein catabolic process
Y	0008541	cellular_component	proteasome regulatory particle, lid subcomplex
Y	0030447	biological_process	filamentous growth
Y	0034515	cellular_component	proteasome storage granule
Y	0035753	biological_process	maintenance of DNA trinucleotide repeats
Y	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process
Y	0043248	biological_process	proteasome assembly
Y	0044183	molecular_function	protein folding chaperone
Y	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Y	0051726	biological_process	regulation of cell cycle
Y	0060090	molecular_function	molecular adaptor activity
Y	0070390	cellular_component	transcription export complex 2
Y	0072742	biological_process	SAGA complex localization to transcription regulatory region
Z	0000502	cellular_component	proteasome complex
Z	0004175	molecular_function	endopeptidase activity
Z	0005515	molecular_function	protein binding
Z	0005634	cellular_component	nucleus
Z	0005737	cellular_component	cytoplasm
Z	0005783	cellular_component	endoplasmic reticulum
Z	0006511	biological_process	ubiquitin-dependent protein catabolic process
Z	0008540	cellular_component	proteasome regulatory particle, base subcomplex
Z	0030234	molecular_function	enzyme regulator activity
Z	0030674	molecular_function	protein-macromolecule adaptor activity
Z	0034515	cellular_component	proteasome storage granule
Z	0042176	biological_process	regulation of protein catabolic process
Z	0043161	biological_process	proteasome-mediated ubiquitin-dependent protein catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	binding site for residue ATP H 501

Chain	Residue
H	ASP210
H	ARG261
H	GLU310
H	HIS392
H	GLY416
H	ALA417
H	ARG420
H	MG502
H	HOH601
I	ASP314
I	ARG340
H	GLY212
I	ARG343
H	PRO252
H	GLY253
H	THR254
H	GLY255
H	LYS256
H	THR257
H	LEU258

---

site_id	AC2
Number of Residues	5
Details	binding site for residue MG H 502

Chain	Residue
H	THR257
H	ATP501
H	HOH601
H	HOH602
H	HOH603

---

site_id	AC3
Number of Residues	21
Details	binding site for residue ATP I 501

Chain	Residue
I	GLY185
I	GLY226
I	THR227
I	GLY228
I	LYS229
I	THR230
I	LEU231
I	GLU283
I	THR328
I	ILE361
I	HIS365
I	GLY389
I	ALA390
I	GLN393
I	MG502
I	HOH601
I	HOH602
J	ASN277
J	ASP280
J	ARG306
J	ARG309

---

site_id	AC4
Number of Residues	5
Details	binding site for residue MG I 502

Chain	Residue
I	THR230
I	ATP501
I	HOH601
I	HOH602
I	HOH603

---

site_id	AC5
Number of Residues	16
Details	binding site for residue ADP K 501

Chain	Residue
K	GLY175
K	GLY176
K	PRO215
K	GLY216
K	THR217
K	GLY218
K	LYS219
K	THR220
K	MET221
K	ASN319
K	ILE352
K	GLY380
K	ALA381
K	ALA384
K	MG502
K	HOH601

---

site_id	AC6
Number of Residues	7
Details	binding site for residue MG K 502

Chain	Residue
K	THR220
K	ASN319
K	ADP501
K	HOH601
K	HOH602
K	HOH603
K	HOH604

---

site_id	AC7
Number of Residues	14
Details	binding site for residue ADP L 501

Chain	Residue
L	ILE183
L	LEU186
L	GLY225
L	THR226
L	GLY227
L	LYS228
L	THR229
L	LEU230
L	ILE360
L	HIS364
L	GLY388
L	ALA389
L	MG502
L	HOH601

---

site_id	AC8
Number of Residues	6
Details	binding site for residue MG L 502

Chain	Residue
L	THR229
L	ADP501
L	HOH601
L	HOH602
L	HOH603
L	HOH604

---

site_id	AC9
Number of Residues	17
Details	binding site for residue ATP M 501

Chain	Residue
M	LYS228
M	THR229
M	GLU282
M	ASN328
M	ILE360
M	HIS364
M	GLY388
M	ALA389
M	LYS392
M	MG502
M	HOH601
M	HOH602
H	ARG367
M	VAL183
M	GLY225
M	THR226
M	GLY227

---

site_id	AD1
Number of Residues	5
Details	binding site for residue MG M 502

Chain	Residue
M	THR229
M	ATP501
M	HOH601
M	HOH602
M	HOH603

---

site_id	AD2
Number of Residues	19
Details	binding site for residue ATP J 501

Chain	Residue
J	MET149
J	GLY192
J	THR193
J	GLY194
J	LYS195
J	THR196
J	LEU197
J	ARG200
J	ILE250
J	ILE327
J	HIS331
J	GLY355
J	ALA356
J	LYS359
J	MG502
K	LEU300
K	ARG330
K	PRO331
K	ARG333

---

site_id	AD3
Number of Residues	5
Details	binding site for residue MG J 502

Chain	Residue
J	THR196
J	ATP501
J	HOH601
J	HOH602
J	HOH603

---

site_id	AD4
Number of Residues	32
Details	binding site for Ligand residues ARG N 813 through PRO Z 254 bound to THR Z 611

Chain	Residue
I	ARG61
N	PHE242
N	LEU245
N	ASP250
N	GLY252
N	LEU253
N	ALA255
N	GLN256
N	ALA258
N	ALA810
N	LYS811
N	ALA812
N	ALA814
N	LYS815
N	LYS816
N	THR817
Z	CYS252
Z	VAL253
Z	LEU255
Z	LEU256
Z	GLY610
Z	THR611
Z	GLY612
Z	ASP613
Z	GLU727
Z	ASN810
Z	SER811
Z	ILE812
Z	ALA814
Z	MET815
Z	GLY816
Z	LEU817

---

site_id	AD5
Number of Residues	26
Details	binding site for Di-peptide ARG I 54 and TYR Z 248

Chain	Residue
I	THR53
I	CYS55
I	LYS56
I	LYS58
I	ILE247
I	GLY249
I	SER250
I	GLU251
J	GLU274
J	ASN277
Z	ASP13
Z	GLU50
Z	LEU51
Z	LEU52
Z	VAL53
Z	ARG55
Z	LEU56
Z	PRO209
Z	ARG244
Z	VAL245
Z	CYS246
Z	GLN247
Z	MET249
Z	VAL250
Z	ALA251
Z	CYS252

---

site_id	AD6
Number of Residues	26
Details	binding site for Di-peptide ARG I 54 and TYR Z 248

Chain	Residue
I	THR53
I	CYS55
I	LYS56
I	LYS58
I	ILE247
I	GLY249
I	SER250
I	GLU251
J	GLU274
J	ASN277
Z	ASP13
Z	GLU50
Z	LEU51
Z	LEU52
Z	VAL53
Z	ARG55
Z	LEU56
Z	PRO209
Z	ARG244
Z	VAL245
Z	CYS246
Z	GLN247
Z	MET249
Z	VAL250
Z	ALA251
Z	CYS252

---

site_id	AD7
Number of Residues	26
Details	binding site for Di-peptide ARG I 54 and TYR Z 248

Chain	Residue
I	THR53
I	CYS55
I	LYS56
I	LYS58
I	ILE247
I	GLY249
I	SER250
I	GLU251
J	GLU274
J	ASN277
Z	ASP13
Z	GLU50
Z	LEU51
Z	LEU52
Z	VAL53
Z	ARG55
Z	LEU56
Z	PRO209
Z	ARG244
Z	VAL245
Z	CYS246
Z	GLN247
Z	MET249
Z	VAL250
Z	ALA251
Z	CYS252

---

site_id	AD8
Number of Residues	21
Details	binding site for Di-peptide CYS I 55 and LEU Z 916

Chain	Residue
I	THR53
I	ARG54
I	LYS56
I	LEU57
I	LYS58
I	LEU59
Z	GLN23
Z	LEU51
Z	LEU52
Z	VAL53
Z	GLU54
Z	LEU56
Z	LYS57
Z	GLU58
Z	LEU63
Z	TYR64
Z	GLN247
Z	LEU914
Z	ALA915
Z	ASN917
Z	ASP918

---

site_id	AD9
Number of Residues	20
Details	binding site for Di-peptide LYS I 58 and ASP Z 918

Chain	Residue
I	ARG54
I	CYS55
I	LYS56
I	LEU57
I	LEU59
I	LEU60
I	ARG61
Z	ARG55
Z	LEU56
Z	LYS57
Z	ASP59
Z	LEU63
Z	VAL250
Z	ALA251
Z	LYS728
Z	GLU729
Z	PHE912
Z	ASN917
Z	GLU919
Z	GLY920

---

site_id	AE1
Number of Residues	28
Details	binding site for Di-peptide ARG I 61 and LEU Z 255

Chain	Residue
I	LEU57
I	LYS58
I	LEU59
I	LEU60
I	MET62
I	GLU63
I	ILE65
I	GLN254
I	TYR256
I	ARG300
N	ALA812
N	ARG813
N	LYS816
N	GLU820
Z	ASP59
Z	ASP60
Z	SER62
Z	LEU63
Z	TYR64
Z	GLU65
Z	LYS105
Z	LYS213
Z	CYS252
Z	VAL253
Z	PRO254
Z	LEU256
Z	PRO257
Z	LYS728

---

site_id	AE2
Number of Residues	23
Details	binding site for Di-peptide ARG I 61 and LYS Z 728

Chain	Residue
I	LEU57
I	LYS58
I	LEU59
I	LEU60
I	MET62
I	GLU63
I	ILE65
I	LYS66
N	ALA812
N	ARG813
Z	ASP59
Z	ASP60
Z	SER62
Z	LEU63
Z	TYR64
Z	GLU65
Z	LYS105
Z	PRO254
Z	LEU255
Z	GLU727
Z	GLU729
Z	ALA730
Z	GLY731

---

site_id	AE3
Number of Residues	19
Details	binding site for Di-peptide MET I 62 and LYS Z 728

Chain	Residue
I	LYS58
I	LEU59
I	LEU60
I	ARG61
I	GLU63
I	ARG64
I	ILE65
I	LYS66
Z	ASP60
Z	SER61
Z	LEU63
Z	TYR64
Z	ALA66
Z	ASP723
Z	GLU724
Z	GLU727
Z	GLU729
Z	ALA730
Z	GLY731

---

site_id	AE4
Number of Residues	19
Details	binding site for Di-peptide MET I 62 and LYS Z 728

Chain	Residue
I	LYS58
I	LEU59
I	LEU60
I	ARG61
I	GLU63
I	ARG64
I	ILE65
I	LYS66
Z	ASP60
Z	SER61
Z	LEU63
Z	TYR64
Z	ALA66
Z	ASP723
Z	GLU724
Z	GLU727
Z	GLU729
Z	ALA730
Z	GLY731

---

site_id	AE5
Number of Residues	19
Details	binding site for Di-peptide MET I 62 and LYS Z 728

Chain	Residue
I	LYS58
I	LEU59
I	LEU60
I	ARG61
I	GLU63
I	ARG64
I	ILE65
I	LYS66
Z	ASP60
Z	SER61
Z	LEU63
Z	TYR64
Z	ALA66
Z	ASP723
Z	GLU724
Z	GLU727
Z	GLU729
Z	ALA730
Z	GLY731

---

site_id	AE6
Number of Residues	21
Details	binding site for Di-peptide MET I 62 and GLU Z 727

Chain	Residue
I	LEU59
I	LEU60
I	ARG61
I	GLU63
I	ARG64
I	ILE65
I	LYS66
Z	ASP60
Z	SER61
Z	LEU63
Z	TYR64
Z	ALA66
Z	PRO254
Z	ASP613
Z	ASP723
Z	GLU724
Z	GLU725
Z	GLU726
Z	LYS728
Z	GLU729
Z	GLY731

---

site_id	AE7
Number of Residues	23
Details	binding site for Di-peptide LYS I 66 and GLU Z 735

Chain	Residue
I	MET62
I	ARG64
I	ILE65
I	ASP67
I	HIS68
I	LEU69
I	LEU70
Z	SER62
Z	TYR64
Z	GLU65
Z	SER67
Z	LEU68
Z	ASN69
Z	LYS720
Z	GLU724
Z	LYS728
Z	GLY731
Z	VAL733
Z	ASP734
Z	LEU736
Z	ALA737
Z	TYR738
Z	ALA739

---

site_id	AE8
Number of Residues	23
Details	binding site for Di-peptide LYS I 66 and GLU Z 735

Chain	Residue
I	MET62
I	ARG64
I	ILE65
I	ASP67
I	HIS68
I	LEU69
I	LEU70
Z	SER62
Z	TYR64
Z	GLU65
Z	SER67
Z	LEU68
Z	ASN69
Z	LYS720
Z	GLU724
Z	LYS728
Z	GLY731
Z	VAL733
Z	ASP734
Z	LEU736
Z	ALA737
Z	TYR738
Z	ALA739

---

site_id	AE9
Number of Residues	25
Details	binding site for Di-peptide ASP I 67 and ASP Z 734

Chain	Residue
H	ARG62
I	GLU63
I	ILE65
I	LYS66
I	HIS68
I	LEU69
I	LEU70
I	LEU71
Z	GLN17
Z	ILE18
Z	PRO20
Z	LEU63
Z	TYR64
Z	GLU65
Z	ALA66
Z	LEU68
Z	ASN69
Z	ALA730
Z	GLY731
Z	ILE732
Z	VAL733
Z	GLU735
Z	LEU736
Z	ALA737
Z	TYR738

---

site_id	AF1
Number of Residues	25
Details	binding site for Di-peptide ASP I 67 and ASP Z 734

Chain	Residue
H	ARG62
I	GLU63
I	ILE65
I	LYS66
I	HIS68
I	LEU69
I	LEU70
I	LEU71
Z	GLN17
Z	ILE18
Z	PRO20
Z	LEU63
Z	TYR64
Z	GLU65
Z	ALA66
Z	LEU68
Z	ASN69
Z	ALA730
Z	GLY731
Z	ILE732
Z	VAL733
Z	GLU735
Z	LEU736
Z	ALA737
Z	TYR738

---

site_id	AF2
Number of Residues	24
Details	binding site for Di-peptide LEU I 70 and TYR Z 738

Chain	Residue
I	ILE65
I	LYS66
I	ASP67
I	HIS68
I	LEU69
I	LEU71
I	GLU72
I	GLU73
I	GLU74
Z	LYS28
Z	LEU68
Z	ASN69
Z	LEU71
Z	LYS72
Z	GLU73
Z	SER74
Z	ASP734
Z	GLU735
Z	LEU736
Z	ALA737
Z	ALA739
Z	VAL740
Z	LEU741
Z	GLY742

---

site_id	AF3
Number of Residues	24
Details	binding site for Di-peptide LEU I 70 and TYR Z 738

Chain	Residue
I	ILE65
I	LYS66
I	ASP67
I	HIS68
I	LEU69
I	LEU71
I	GLU72
I	GLU73
I	GLU74
Z	LYS28
Z	LEU68
Z	ASN69
Z	LEU71
Z	LYS72
Z	GLU73
Z	SER74
Z	ASP734
Z	GLU735
Z	LEU736
Z	ALA737
Z	ALA739
Z	VAL740
Z	LEU741
Z	GLY742

---

site_id	AF4
Number of Residues	23
Details	binding site for Di-peptide LEU I 70 and ALA Z 737

Chain	Residue
I	LYS66
I	ASP67
I	HIS68
I	LEU69
I	LEU71
I	GLU72
I	GLU73
I	GLU74
Z	LYS28
Z	LEU68
Z	ASN69
Z	LEU71
Z	LYS72
Z	GLU73
Z	SER74
Z	VAL733
Z	ASP734
Z	GLU735
Z	LEU736
Z	TYR738
Z	ALA739
Z	VAL740
Z	LEU741

---

site_id	AF5
Number of Residues	26
Details	binding site for Di-peptide GLU I 74 and LEU Z 741

Chain	Residue
H	LYS66
I	LEU70
I	LEU71
I	GLU72
I	GLU73
I	PHE75
I	VAL76
I	SER77
I	ASN78
Z	LYS28
Z	ALA70
Z	LEU71
Z	LYS72
Z	GLU73
Z	ILE75
Z	LYS76
Z	ASN77
Z	SER78
Z	THR79
Z	ALA737
Z	TYR738
Z	ALA739
Z	VAL740
Z	GLY742
Z	ILE743
Z	LEU745

---

site_id	AF6
Number of Residues	17
Details	binding site for Di-peptide ILE I 81 and LEU Z 748

Chain	Residue
H	GLU71
I	SER77
I	ASN78
I	SER79
I	GLU80
I	LEU82
I	LYS83
I	PRO84
I	PHE85
Z	ILE75
Z	THR79
Z	SER80
Z	MET82
Z	ALA744
Z	ILE746
Z	ALA747
Z	GLY749

---

site_id	AF7
Number of Residues	15
Details	binding site for Di-peptide TYR I 181 and ARG Z 909

Chain	Residue
I	SER180
I	SER182
I	ASP183
I	LYS195
I	GLN239
Z	ASP175
Z	THR177
Z	ASP180
Z	SER182
Z	ILE908
Z	PRO910
Z	LYS911
Z	ILE913
Z	VAL927
Z	PRO942

---

site_id	AF8
Number of Residues	15
Details	binding site for Di-peptide TYR I 181 and ARG Z 909

Chain	Residue
I	SER180
I	SER182
I	ASP183
I	LYS195
I	GLN239
Z	ASP175
Z	THR177
Z	ASP180
Z	SER182
Z	ILE908
Z	PRO910
Z	LYS911
Z	ILE913
Z	VAL927
Z	PRO942

---

site_id	AF9
Number of Residues	15
Details	binding site for Di-peptide TYR I 181 and ARG Z 909

Chain	Residue
I	SER180
I	SER182
I	ASP183
I	LYS195
I	GLN239
Z	ASP175
Z	THR177
Z	ASP180
Z	SER182
Z	ILE908
Z	PRO910
Z	LYS911
Z	ILE913
Z	VAL927
Z	PRO942

---

site_id	AG1
Number of Residues	15
Details	binding site for Di-peptide TYR I 181 and ARG Z 909

Chain	Residue
I	SER180
I	SER182
I	ASP183
I	LYS195
I	GLN239
Z	ASP175
Z	THR177
Z	ASP180
Z	SER182
Z	ILE908
Z	PRO910
Z	LYS911
Z	ILE913
Z	VAL927
Z	PRO942

---

site_id	AG2
Number of Residues	15
Details	binding site for Di-peptide TYR I 181 and ARG Z 909

Chain	Residue
I	SER180
I	SER182
I	ASP183
I	LYS195
I	GLN239
Z	ASP175
Z	THR177
Z	ASP180
Z	SER182
Z	ILE908
Z	PRO910
Z	LYS911
Z	ILE913
Z	VAL927
Z	PRO942

---

site_id	AG3
Number of Residues	15
Details	binding site for Di-peptide TYR I 181 and ARG Z 909

Chain	Residue
I	SER180
I	SER182
I	ASP183
I	LYS195
I	GLN239
Z	ASP175
Z	THR177
Z	ASP180
Z	SER182
Z	ILE908
Z	PRO910
Z	LYS911
Z	ILE913
Z	VAL927
Z	PRO942

---

site_id	AG4
Number of Residues	15
Details	binding site for Di-peptide TYR I 181 and ARG Z 909

Chain	Residue
I	SER180
I	SER182
I	ASP183
I	LYS195
I	GLN239
Z	ASP175
Z	THR177
Z	ASP180
Z	SER182
Z	ILE908
Z	PRO910
Z	LYS911
Z	ILE913
Z	VAL927
Z	PRO942

---

site_id	AG5
Number of Residues	17
Details	binding site for Di-peptide ASP Z 145 and MET I 409

Chain	Residue
I	LEU109
I	GLU142
I	PRO143
I	GLY144
I	SER146
I	ARG408
I	GLN410
Z	SER144
Z	PHE146
Z	TRP149
Z	ASN380
Z	ASN405
Z	TRP406
Z	VAL407
Z	TYR408
Z	THR410
Z	LYS411

---

site_id	AG6
Number of Residues	17
Details	binding site for Di-peptide ASP Z 145 and MET I 409

Chain	Residue
I	LEU109
I	GLU142
I	PRO143
I	GLY144
I	SER146
I	ARG408
I	GLN410
Z	SER144
Z	PHE146
Z	TRP149
Z	ASN380
Z	ASN405
Z	TRP406
Z	VAL407
Z	TYR408
Z	THR410
Z	LYS411

---

site_id	AG7
Number of Residues	17
Details	binding site for Di-peptide ASP Z 145 and MET I 409

Chain	Residue
I	LEU109
I	GLU142
I	PRO143
I	GLY144
I	SER146
I	ARG408
I	GLN410
Z	SER144
Z	PHE146
Z	TRP149
Z	ASN380
Z	ASN405
Z	TRP406
Z	VAL407
Z	TYR408
Z	THR410
Z	LYS411

---

site_id	AG8
Number of Residues	17
Details	binding site for Di-peptide ASP Z 145 and MET I 409

Chain	Residue
I	LEU109
I	GLU142
I	PRO143
I	GLY144
I	SER146
I	ARG408
I	GLN410
Z	SER144
Z	PHE146
Z	TRP149
Z	ASN380
Z	ASN405
Z	TRP406
Z	VAL407
Z	TYR408
Z	THR410
Z	LYS411

---

site_id	AG9
Number of Residues	17
Details	binding site for Di-peptide ASP Z 145 and MET I 409

Chain	Residue
I	LEU109
I	GLU142
I	PRO143
I	GLY144
I	SER146
I	ARG408
I	GLN410
Z	SER144
Z	PHE146
Z	TRP149
Z	ASN380
Z	ASN405
Z	TRP406
Z	VAL407
Z	TYR408
Z	THR410
Z	LYS411

---

site_id	AH1
Number of Residues	17
Details	binding site for Di-peptide ASP Z 145 and MET I 409

Chain	Residue
I	LEU109
I	GLU142
I	PRO143
I	GLY144
I	SER146
I	ARG408
I	GLN410
Z	SER144
Z	PHE146
Z	TRP149
Z	ASN380
Z	ASN405
Z	TRP406
Z	VAL407
Z	TYR408
Z	THR410
Z	LYS411

---

site_id	AH2
Number of Residues	34
Details	binding site for Di-peptide LYS Z 213 and LYS N 816

Chain	Residue
N	GLU167
N	LYS209
N	SER210
N	PHE211
N	ASP212
N	LEU214
N	MET215
N	ASN216
N	MET217
N	ARG813
N	ALA814
N	LYS815
N	THR817
N	LYS818
N	LYS819
N	GLU820
Z	GLN168
Z	PRO209
Z	TYR210
Z	PHE211
Z	LEU212
Z	HIS214
Z	ASN215
Z	GLY216
Z	LEU255
Z	LEU256
Z	ILE812
Z	PHE813
Z	ALA814
Z	MET815
Z	LEU817
Z	CYS818
Z	GLY819
Z	ALA820

---

site_id	AH3
Number of Residues	34
Details	binding site for Di-peptide LYS Z 213 and LYS N 816

Chain	Residue
N	GLU167
N	LYS209
N	SER210
N	PHE211
N	ASP212
N	LEU214
N	MET215
N	ASN216
N	MET217
N	ARG813
N	ALA814
N	LYS815
N	THR817
N	LYS818
N	LYS819
N	GLU820
Z	GLN168
Z	PRO209
Z	TYR210
Z	PHE211
Z	LEU212
Z	HIS214
Z	ASN215
Z	GLY216
Z	LEU255
Z	LEU256
Z	ILE812
Z	PHE813
Z	ALA814
Z	MET815
Z	LEU817
Z	CYS818
Z	GLY819
Z	ALA820

---

site_id	AH4
Number of Residues	32
Details	binding site for Di-peptide LEU Z 255 and LYS N 816

Chain	Residue
I	ARG61
N	GLU251
N	GLY252
N	LEU253
N	SER254
N	GLN256
N	ILE257
N	ALA258
N	PHE259
N	ILE289
N	ALA812
N	ARG813
N	ALA814
N	LYS815
N	THR817
N	LYS818
N	LYS819
N	GLU820
Z	LYS213
Z	CYS252
Z	VAL253
Z	PRO254
Z	LEU256
Z	PRO257
Z	ILE812
Z	PHE813
Z	ALA814
Z	MET815
Z	LEU817
Z	CYS818
Z	GLY819
Z	ALA820

---

site_id	AH5
Number of Residues	29
Details	binding site for Di-peptide PRO Z 257 and GLU N 820

Chain	Residue
N	TYR222
N	ASN226
N	LEU253
N	ALA255
N	GLN256
N	ALA258
N	PHE259
N	ASP260
N	LEU261
N	LYS816
N	THR817
N	LYS818
N	LYS819
N	LYS821
N	GLY822
N	ASN824
Z	LEU255
Z	LEU256
Z	PRO258
Z	PRO259
Z	GLU260
Z	ASP261
Z	THR611
Z	GLY816
Z	LEU817
Z	CYS818
Z	GLY819
Z	GLY821
Z	THR822

---

site_id	AH6
Number of Residues	29
Details	binding site for Di-peptide PRO Z 257 and GLU N 820

Chain	Residue
N	TYR222
N	ASN226
N	LEU253
N	ALA255
N	GLN256
N	ALA258
N	PHE259
N	ASP260
N	LEU261
N	LYS816
N	THR817
N	LYS818
N	LYS819
N	LYS821
N	GLY822
N	ASN824
Z	LEU255
Z	LEU256
Z	PRO258
Z	PRO259
Z	GLU260
Z	ASP261
Z	THR611
Z	GLY816
Z	LEU817
Z	CYS818
Z	GLY819
Z	GLY821
Z	THR822

---

site_id	AH7
Number of Residues	29
Details	binding site for Di-peptide GLU Z 632 and VAL N 796

Chain	Residue
N	GLY633
N	SER792
N	GLY793
N	LYS794
N	GLU795
N	GLU797
N	LYS798
N	VAL799
N	ALA800
Z	ASN628
Z	VAL629
Z	LYS630
Z	GLY631
Z	GLU633
Z	ASP634
Z	MET765
Z	PRO777
Z	VAL792
Z	PHE793
Z	ASP794
Z	THR795
Z	THR797
Z	ARG798
Z	PHE799
Z	SER800
N	TYR599
N	CYS629
N	ALA630
N	GLY631

---

Functional Information from PROSITE/UniProt

site_id	PS00674
Number of Residues	19
Details	AAA AAA-protein family signature. IkVMfATNrpntLDpALl.R

Chain	Residue	Details
H	ILE349-ARG367
L	THR321-ARG339
J	ILE288-ARG306
M	VAL321-ARG339
K	VAL312-ARG330
I	VAL322-ARG340

---

site_id	PS00387
Number of Residues	7
Details	PPASE Inorganic pyrophosphatase signature. DDDEIDV

Chain	Residue	Details
U	ASP243-VAL249

---

site_id	PS00388
Number of Residues	23
Details	PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdgdtVtFSPtGRlfQVEYAleA

Chain	Residue	Details
f	TYR6-ALA28
a	TYR12-ALA34
d	TYR4-ALA26
e	TYR8-ALA30
c	TYR6-SER28
g	TYR8-ALA30
b	TYR5-ALA27

---

site_id	PS00854
Number of Residues	48
Details	PROTEASOME_BETA_1 Proteasome beta-type subunits signature. VGVkGknCVVLGCErrstlklqdtritps.KvskidshvvlsfsGlnAD

Chain	Residue	Details
d	VAL34-ASP81
c	ILE36-ASP83
h	MET13-ASP60
k	LEU5-ASP52
j	VAL13-ASP59
6	LEU21-ASP68
l	LEU79-ASP126
i	VAL33-ASP80
7	ILE45-ASP92

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING:

Chain	Residue	Details
J	GLY189
Z	SER178
V	ASP122
c	LYS231
C	LYS100
C	LYS199
C	LYS231

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19779198

Chain	Residue	Details
M	TYR180
H	SER231
I	LYS255
I	LYS290

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:17287358

Chain	Residue	Details
Z	THR24

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956

Chain	Residue	Details
Z	SER187
Z	SER695

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	8
Details	M-CSA 177

Chain	Residue	Details
i	THR30	covalently attached, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor
i	ASP46	activator, steric locator
i	ARG48	activator
i	LYS62	activator, electrostatic stabiliser
i	GLY76	electrostatic stabiliser
i	SER158	activator, electrostatic stabiliser
i	ASP195	activator, steric locator
i	SER198	activator, electrostatic stabiliser

---

site_id	MCSA2
Number of Residues	8
Details	M-CSA 177

Chain	Residue	Details
2	THR30	covalently attached, hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor
2	ASP46	activator, steric locator
2	ARG48	activator
2	LYS62	activator, electrostatic stabiliser
2	GLY76	electrostatic stabiliser
2	SER158	activator, electrostatic stabiliser
2	ASP195	activator, steric locator
2	SER198	activator, electrostatic stabiliser

---