Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6FVJ

TesA a major thioesterase from Mycobacterium tuberculosis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0008126	molecular_function	acetylesterase activity
A	0008610	biological_process	lipid biosynthetic process
A	0009058	biological_process	biosynthetic process
A	0047617	molecular_function	fatty acyl-CoA hydrolase activity
A	0052167	biological_process	symbiont-mediated perturbation of host innate immune response
A	0052815	molecular_function	medium-chain fatty acyl-CoA hydrolase activity
A	0052816	molecular_function	long-chain fatty acyl-CoA hydrolase activity
A	0071770	biological_process	DIM/DIP cell wall layer assembly
B	0005886	cellular_component	plasma membrane
B	0008126	molecular_function	acetylesterase activity
B	0008610	biological_process	lipid biosynthetic process
B	0009058	biological_process	biosynthetic process
B	0047617	molecular_function	fatty acyl-CoA hydrolase activity
B	0052167	biological_process	symbiont-mediated perturbation of host innate immune response
B	0052815	molecular_function	medium-chain fatty acyl-CoA hydrolase activity
B	0052816	molecular_function	long-chain fatty acyl-CoA hydrolase activity
B	0071770	biological_process	DIM/DIP cell wall layer assembly
C	0005886	cellular_component	plasma membrane
C	0008126	molecular_function	acetylesterase activity
C	0008610	biological_process	lipid biosynthetic process
C	0009058	biological_process	biosynthetic process
C	0047617	molecular_function	fatty acyl-CoA hydrolase activity
C	0052167	biological_process	symbiont-mediated perturbation of host innate immune response
C	0052815	molecular_function	medium-chain fatty acyl-CoA hydrolase activity
C	0052816	molecular_function	long-chain fatty acyl-CoA hydrolase activity
C	0071770	biological_process	DIM/DIP cell wall layer assembly
D	0005886	cellular_component	plasma membrane
D	0008126	molecular_function	acetylesterase activity
D	0008610	biological_process	lipid biosynthetic process
D	0009058	biological_process	biosynthetic process
D	0047617	molecular_function	fatty acyl-CoA hydrolase activity
D	0052167	biological_process	symbiont-mediated perturbation of host innate immune response
D	0052815	molecular_function	medium-chain fatty acyl-CoA hydrolase activity
D	0052816	molecular_function	long-chain fatty acyl-CoA hydrolase activity
D	0071770	biological_process	DIM/DIP cell wall layer assembly
E	0005886	cellular_component	plasma membrane
E	0008126	molecular_function	acetylesterase activity
E	0008610	biological_process	lipid biosynthetic process
E	0009058	biological_process	biosynthetic process
E	0047617	molecular_function	fatty acyl-CoA hydrolase activity
E	0052167	biological_process	symbiont-mediated perturbation of host innate immune response
E	0052815	molecular_function	medium-chain fatty acyl-CoA hydrolase activity
E	0052816	molecular_function	long-chain fatty acyl-CoA hydrolase activity
E	0071770	biological_process	DIM/DIP cell wall layer assembly
F	0005886	cellular_component	plasma membrane
F	0008126	molecular_function	acetylesterase activity
F	0008610	biological_process	lipid biosynthetic process
F	0009058	biological_process	biosynthetic process
F	0047617	molecular_function	fatty acyl-CoA hydrolase activity
F	0052167	biological_process	symbiont-mediated perturbation of host innate immune response
F	0052815	molecular_function	medium-chain fatty acyl-CoA hydrolase activity
F	0052816	molecular_function	long-chain fatty acyl-CoA hydrolase activity
F	0071770	biological_process	DIM/DIP cell wall layer assembly
G	0005886	cellular_component	plasma membrane
G	0008126	molecular_function	acetylesterase activity
G	0008610	biological_process	lipid biosynthetic process
G	0009058	biological_process	biosynthetic process
G	0047617	molecular_function	fatty acyl-CoA hydrolase activity
G	0052167	biological_process	symbiont-mediated perturbation of host innate immune response
G	0052815	molecular_function	medium-chain fatty acyl-CoA hydrolase activity
G	0052816	molecular_function	long-chain fatty acyl-CoA hydrolase activity
G	0071770	biological_process	DIM/DIP cell wall layer assembly
H	0005886	cellular_component	plasma membrane
H	0008126	molecular_function	acetylesterase activity
H	0008610	biological_process	lipid biosynthetic process
H	0009058	biological_process	biosynthetic process
H	0047617	molecular_function	fatty acyl-CoA hydrolase activity
H	0052167	biological_process	symbiont-mediated perturbation of host innate immune response
H	0052815	molecular_function	medium-chain fatty acyl-CoA hydrolase activity
H	0052816	molecular_function	long-chain fatty acyl-CoA hydrolase activity
H	0071770	biological_process	DIM/DIP cell wall layer assembly

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue E9H A 401

Chain	Residue
A	HIS36
A	ALA37
A	SER104
A	MET105
A	HIS236
A	MPD402
A	HOH511

site_id	AC2
Number of Residues	7
Details	binding site for residue MPD A 402

Chain	Residue
A	SER133
A	ILE185
A	ILE210
A	E9H401
F	ARG139
A	ALA131
A	CYS132

site_id	AC3
Number of Residues	4
Details	binding site for residue MPD A 403

Chain	Residue
A	ASP43
A	PHE237
A	ASN240
D	ARG49

site_id	AC4
Number of Residues	4
Details	binding site for residue CA A 404

Chain	Residue
A	GLU50
A	LEU243
D	ARG49
D	PHE51

site_id	AC5
Number of Residues	4
Details	binding site for residue MPD B 402

Chain	Residue
B	SER104
B	SER133
B	ILE210
B	E9H401

site_id	AC6
Number of Residues	5
Details	binding site for residue MPD B 403

Chain	Residue
B	HIS36
B	ASP43
B	PHE237
B	ASN240
B	HOH507

site_id	AC7
Number of Residues	3
Details	binding site for residue CA C 302

Chain	Residue
B	HOH553
C	ARG49
C	HOH409

site_id	AC8
Number of Residues	4
Details	binding site for residue MPD C 303

Chain	Residue
C	MET108
C	CYS132
C	SER133
C	E9H301

site_id	AC9
Number of Residues	4
Details	binding site for residue MPD C 304

Chain	Residue
C	HIS36
C	ASP43
C	ASN240
C	HOH412

site_id	AD1
Number of Residues	6
Details	binding site for residue MPD D 302

Chain	Residue
D	MET108
D	ALA131
D	SER133
D	ILE138
D	ILE210
D	E9H301

site_id	AD2
Number of Residues	4
Details	binding site for residue MPD D 303

Chain	Residue
D	ASP43
D	TYR44
D	PHE237
D	ASN240

site_id	AD3
Number of Residues	7
Details	binding site for residue MPD E 302

Chain	Residue
E	SER104
E	MET105
E	ALA131
E	SER133
E	ARG139
E	ILE210
E	E9H301

site_id	AD4
Number of Residues	7
Details	binding site for residue MPD F 302

Chain	Residue
F	SER104
F	MET108
F	CYS132
F	SER133
F	ILE138
F	ILE185
F	ILE210

site_id	AD5
Number of Residues	5
Details	binding site for residue MPD F 303

Chain	Residue
F	HIS36
F	ASP43
F	TYR44
F	PHE237
F	ASN240

site_id	AD6
Number of Residues	4
Details	binding site for residue MPD G 302

Chain	Residue
G	SER104
G	ALA131
G	SER133
G	ILE210

site_id	AD7
Number of Residues	11
Details	binding site for Di-peptide E9H B 401 and SER B 104

Chain	Residue
B	HIS36
B	ALA37
B	HIS103
B	MET105
B	GLY106
B	GLY107
B	SER130
B	ALA131
B	CYS132
B	HIS236
B	MPD402

site_id	AD8
Number of Residues	11
Details	binding site for Di-peptide E9H C 301 and SER C 104

Chain	Residue
C	HIS36
C	ALA37
C	HIS103
C	MET105
C	GLY106
C	GLY107
C	SER130
C	ALA131
C	CYS132
C	HIS236
C	MPD303

site_id	AD9
Number of Residues	11
Details	binding site for Di-peptide E9H D 301 and SER D 104

Chain	Residue
D	HIS103
D	MET105
D	GLY106
D	GLY107
D	SER130
D	ALA131
D	CYS132
D	HIS236
D	MPD302
D	HIS36
D	ALA37

site_id	AE1
Number of Residues	12
Details	binding site for Di-peptide E9H E 301 and SER E 104

Chain	Residue
E	HIS36
E	ALA37
E	HIS103
E	MET105
E	GLY106
E	GLY107
E	SER130
E	ALA131
E	CYS132
E	HIS236
E	MPD302
E	HOH405

site_id	AE2
Number of Residues	12
Details	binding site for Di-peptide E9H F 301 and SER F 104

Chain	Residue
F	HIS36
F	ALA37
F	HIS103
F	MET105
F	GLY106
F	GLY107
F	SER130
F	ALA131
F	CYS132
F	HIS236
F	MPD302
F	HOH410

site_id	AE3
Number of Residues	11
Details	binding site for Di-peptide E9H G 301 and SER G 104

Chain	Residue
G	HIS36
G	ALA37
G	HIS103
G	MET105
G	GLY106
G	GLY107
G	SER130
G	ALA131
G	CYS132
G	HIS236
G	MPD302

site_id	AE4
Number of Residues	11
Details	binding site for Di-peptide E9H H 301 and SER H 104

Chain	Residue
D	ARG157
H	HIS36
H	ALA37
H	HIS103
H	MET105
H	GLY106
H	GLY107
H	SER130
H	ALA131
H	CYS132
H	HIS236

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Active site: {"evidences":[{"source":"PubMed","id":"30292819","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)