6FVJ
TesA a major thioesterase from Mycobacterium tuberculosis
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005886 | cellular_component | plasma membrane |
A | 0006629 | biological_process | lipid metabolic process |
A | 0008126 | molecular_function | acetylesterase activity |
A | 0008610 | biological_process | lipid biosynthetic process |
A | 0009058 | biological_process | biosynthetic process |
A | 0016787 | molecular_function | hydrolase activity |
A | 0047617 | molecular_function | fatty acyl-CoA hydrolase activity |
A | 0052167 | biological_process | symbiont-mediated perturbation of host innate immune response |
A | 0071770 | biological_process | DIM/DIP cell wall layer assembly |
B | 0005886 | cellular_component | plasma membrane |
B | 0006629 | biological_process | lipid metabolic process |
B | 0008126 | molecular_function | acetylesterase activity |
B | 0008610 | biological_process | lipid biosynthetic process |
B | 0009058 | biological_process | biosynthetic process |
B | 0016787 | molecular_function | hydrolase activity |
B | 0047617 | molecular_function | fatty acyl-CoA hydrolase activity |
B | 0052167 | biological_process | symbiont-mediated perturbation of host innate immune response |
B | 0071770 | biological_process | DIM/DIP cell wall layer assembly |
C | 0005886 | cellular_component | plasma membrane |
C | 0006629 | biological_process | lipid metabolic process |
C | 0008126 | molecular_function | acetylesterase activity |
C | 0008610 | biological_process | lipid biosynthetic process |
C | 0009058 | biological_process | biosynthetic process |
C | 0016787 | molecular_function | hydrolase activity |
C | 0047617 | molecular_function | fatty acyl-CoA hydrolase activity |
C | 0052167 | biological_process | symbiont-mediated perturbation of host innate immune response |
C | 0071770 | biological_process | DIM/DIP cell wall layer assembly |
D | 0005886 | cellular_component | plasma membrane |
D | 0006629 | biological_process | lipid metabolic process |
D | 0008126 | molecular_function | acetylesterase activity |
D | 0008610 | biological_process | lipid biosynthetic process |
D | 0009058 | biological_process | biosynthetic process |
D | 0016787 | molecular_function | hydrolase activity |
D | 0047617 | molecular_function | fatty acyl-CoA hydrolase activity |
D | 0052167 | biological_process | symbiont-mediated perturbation of host innate immune response |
D | 0071770 | biological_process | DIM/DIP cell wall layer assembly |
E | 0005886 | cellular_component | plasma membrane |
E | 0006629 | biological_process | lipid metabolic process |
E | 0008126 | molecular_function | acetylesterase activity |
E | 0008610 | biological_process | lipid biosynthetic process |
E | 0009058 | biological_process | biosynthetic process |
E | 0016787 | molecular_function | hydrolase activity |
E | 0047617 | molecular_function | fatty acyl-CoA hydrolase activity |
E | 0052167 | biological_process | symbiont-mediated perturbation of host innate immune response |
E | 0071770 | biological_process | DIM/DIP cell wall layer assembly |
F | 0005886 | cellular_component | plasma membrane |
F | 0006629 | biological_process | lipid metabolic process |
F | 0008126 | molecular_function | acetylesterase activity |
F | 0008610 | biological_process | lipid biosynthetic process |
F | 0009058 | biological_process | biosynthetic process |
F | 0016787 | molecular_function | hydrolase activity |
F | 0047617 | molecular_function | fatty acyl-CoA hydrolase activity |
F | 0052167 | biological_process | symbiont-mediated perturbation of host innate immune response |
F | 0071770 | biological_process | DIM/DIP cell wall layer assembly |
G | 0005886 | cellular_component | plasma membrane |
G | 0006629 | biological_process | lipid metabolic process |
G | 0008126 | molecular_function | acetylesterase activity |
G | 0008610 | biological_process | lipid biosynthetic process |
G | 0009058 | biological_process | biosynthetic process |
G | 0016787 | molecular_function | hydrolase activity |
G | 0047617 | molecular_function | fatty acyl-CoA hydrolase activity |
G | 0052167 | biological_process | symbiont-mediated perturbation of host innate immune response |
G | 0071770 | biological_process | DIM/DIP cell wall layer assembly |
H | 0005886 | cellular_component | plasma membrane |
H | 0006629 | biological_process | lipid metabolic process |
H | 0008126 | molecular_function | acetylesterase activity |
H | 0008610 | biological_process | lipid biosynthetic process |
H | 0009058 | biological_process | biosynthetic process |
H | 0016787 | molecular_function | hydrolase activity |
H | 0047617 | molecular_function | fatty acyl-CoA hydrolase activity |
H | 0052167 | biological_process | symbiont-mediated perturbation of host innate immune response |
H | 0071770 | biological_process | DIM/DIP cell wall layer assembly |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | binding site for residue E9H A 401 |
Chain | Residue |
A | HIS36 |
A | ALA37 |
A | SER104 |
A | MET105 |
A | HIS236 |
A | MPD402 |
A | HOH511 |
site_id | AC2 |
Number of Residues | 7 |
Details | binding site for residue MPD A 402 |
Chain | Residue |
A | SER133 |
A | ILE185 |
A | ILE210 |
A | E9H401 |
F | ARG139 |
A | ALA131 |
A | CYS132 |
site_id | AC3 |
Number of Residues | 4 |
Details | binding site for residue MPD A 403 |
Chain | Residue |
A | ASP43 |
A | PHE237 |
A | ASN240 |
D | ARG49 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue CA A 404 |
Chain | Residue |
A | GLU50 |
A | LEU243 |
D | ARG49 |
D | PHE51 |
site_id | AC5 |
Number of Residues | 4 |
Details | binding site for residue MPD B 402 |
Chain | Residue |
B | SER104 |
B | SER133 |
B | ILE210 |
B | E9H401 |
site_id | AC6 |
Number of Residues | 5 |
Details | binding site for residue MPD B 403 |
Chain | Residue |
B | HIS36 |
B | ASP43 |
B | PHE237 |
B | ASN240 |
B | HOH507 |
site_id | AC7 |
Number of Residues | 3 |
Details | binding site for residue CA C 302 |
Chain | Residue |
B | HOH553 |
C | ARG49 |
C | HOH409 |
site_id | AC8 |
Number of Residues | 4 |
Details | binding site for residue MPD C 303 |
Chain | Residue |
C | MET108 |
C | CYS132 |
C | SER133 |
C | E9H301 |
site_id | AC9 |
Number of Residues | 4 |
Details | binding site for residue MPD C 304 |
Chain | Residue |
C | HIS36 |
C | ASP43 |
C | ASN240 |
C | HOH412 |
site_id | AD1 |
Number of Residues | 6 |
Details | binding site for residue MPD D 302 |
Chain | Residue |
D | MET108 |
D | ALA131 |
D | SER133 |
D | ILE138 |
D | ILE210 |
D | E9H301 |
site_id | AD2 |
Number of Residues | 4 |
Details | binding site for residue MPD D 303 |
Chain | Residue |
D | ASP43 |
D | TYR44 |
D | PHE237 |
D | ASN240 |
site_id | AD3 |
Number of Residues | 7 |
Details | binding site for residue MPD E 302 |
Chain | Residue |
E | SER104 |
E | MET105 |
E | ALA131 |
E | SER133 |
E | ARG139 |
E | ILE210 |
E | E9H301 |
site_id | AD4 |
Number of Residues | 7 |
Details | binding site for residue MPD F 302 |
Chain | Residue |
F | SER104 |
F | MET108 |
F | CYS132 |
F | SER133 |
F | ILE138 |
F | ILE185 |
F | ILE210 |
site_id | AD5 |
Number of Residues | 5 |
Details | binding site for residue MPD F 303 |
Chain | Residue |
F | HIS36 |
F | ASP43 |
F | TYR44 |
F | PHE237 |
F | ASN240 |
site_id | AD6 |
Number of Residues | 4 |
Details | binding site for residue MPD G 302 |
Chain | Residue |
G | SER104 |
G | ALA131 |
G | SER133 |
G | ILE210 |
site_id | AD7 |
Number of Residues | 11 |
Details | binding site for Di-peptide E9H B 401 and SER B 104 |
Chain | Residue |
B | HIS36 |
B | ALA37 |
B | HIS103 |
B | MET105 |
B | GLY106 |
B | GLY107 |
B | SER130 |
B | ALA131 |
B | CYS132 |
B | HIS236 |
B | MPD402 |
site_id | AD8 |
Number of Residues | 11 |
Details | binding site for Di-peptide E9H C 301 and SER C 104 |
Chain | Residue |
C | HIS36 |
C | ALA37 |
C | HIS103 |
C | MET105 |
C | GLY106 |
C | GLY107 |
C | SER130 |
C | ALA131 |
C | CYS132 |
C | HIS236 |
C | MPD303 |
site_id | AD9 |
Number of Residues | 11 |
Details | binding site for Di-peptide E9H D 301 and SER D 104 |
Chain | Residue |
D | HIS103 |
D | MET105 |
D | GLY106 |
D | GLY107 |
D | SER130 |
D | ALA131 |
D | CYS132 |
D | HIS236 |
D | MPD302 |
D | HIS36 |
D | ALA37 |
site_id | AE1 |
Number of Residues | 12 |
Details | binding site for Di-peptide E9H E 301 and SER E 104 |
Chain | Residue |
E | HIS36 |
E | ALA37 |
E | HIS103 |
E | MET105 |
E | GLY106 |
E | GLY107 |
E | SER130 |
E | ALA131 |
E | CYS132 |
E | HIS236 |
E | MPD302 |
E | HOH405 |
site_id | AE2 |
Number of Residues | 12 |
Details | binding site for Di-peptide E9H F 301 and SER F 104 |
Chain | Residue |
F | HIS36 |
F | ALA37 |
F | HIS103 |
F | MET105 |
F | GLY106 |
F | GLY107 |
F | SER130 |
F | ALA131 |
F | CYS132 |
F | HIS236 |
F | MPD302 |
F | HOH410 |
site_id | AE3 |
Number of Residues | 11 |
Details | binding site for Di-peptide E9H G 301 and SER G 104 |
Chain | Residue |
G | HIS36 |
G | ALA37 |
G | HIS103 |
G | MET105 |
G | GLY106 |
G | GLY107 |
G | SER130 |
G | ALA131 |
G | CYS132 |
G | HIS236 |
G | MPD302 |
site_id | AE4 |
Number of Residues | 11 |
Details | binding site for Di-peptide E9H H 301 and SER H 104 |
Chain | Residue |
D | ARG157 |
H | HIS36 |
H | ALA37 |
H | HIS103 |
H | MET105 |
H | GLY106 |
H | GLY107 |
H | SER130 |
H | ALA131 |
H | CYS132 |
H | HIS236 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 24 |
Details | ACT_SITE: ACT_SITE => ECO:0000305|PubMed:30292819 |
Chain | Residue | Details |
A | SER104 | |
D | SER104 | |
D | ASP208 | |
D | HIS236 | |
E | SER104 | |
E | ASP208 | |
E | HIS236 | |
F | SER104 | |
F | ASP208 | |
F | HIS236 | |
G | SER104 | |
A | ASP208 | |
G | ASP208 | |
G | HIS236 | |
H | SER104 | |
H | ASP208 | |
H | HIS236 | |
A | HIS236 | |
B | SER104 | |
B | ASP208 | |
B | HIS236 | |
C | SER104 | |
C | ASP208 | |
C | HIS236 |