6FVJ
TesA a major thioesterase from Mycobacterium tuberculosis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0008126 | molecular_function | acetylesterase activity |
| A | 0008610 | biological_process | lipid biosynthetic process |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0047617 | molecular_function | fatty acyl-CoA hydrolase activity |
| A | 0052167 | biological_process | symbiont-mediated perturbation of host innate immune response |
| A | 0071770 | biological_process | DIM/DIP cell wall layer assembly |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0008126 | molecular_function | acetylesterase activity |
| B | 0008610 | biological_process | lipid biosynthetic process |
| B | 0009058 | biological_process | biosynthetic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0047617 | molecular_function | fatty acyl-CoA hydrolase activity |
| B | 0052167 | biological_process | symbiont-mediated perturbation of host innate immune response |
| B | 0071770 | biological_process | DIM/DIP cell wall layer assembly |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006629 | biological_process | lipid metabolic process |
| C | 0008126 | molecular_function | acetylesterase activity |
| C | 0008610 | biological_process | lipid biosynthetic process |
| C | 0009058 | biological_process | biosynthetic process |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0047617 | molecular_function | fatty acyl-CoA hydrolase activity |
| C | 0052167 | biological_process | symbiont-mediated perturbation of host innate immune response |
| C | 0071770 | biological_process | DIM/DIP cell wall layer assembly |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006629 | biological_process | lipid metabolic process |
| D | 0008126 | molecular_function | acetylesterase activity |
| D | 0008610 | biological_process | lipid biosynthetic process |
| D | 0009058 | biological_process | biosynthetic process |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0047617 | molecular_function | fatty acyl-CoA hydrolase activity |
| D | 0052167 | biological_process | symbiont-mediated perturbation of host innate immune response |
| D | 0071770 | biological_process | DIM/DIP cell wall layer assembly |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0006629 | biological_process | lipid metabolic process |
| E | 0008126 | molecular_function | acetylesterase activity |
| E | 0008610 | biological_process | lipid biosynthetic process |
| E | 0009058 | biological_process | biosynthetic process |
| E | 0016787 | molecular_function | hydrolase activity |
| E | 0047617 | molecular_function | fatty acyl-CoA hydrolase activity |
| E | 0052167 | biological_process | symbiont-mediated perturbation of host innate immune response |
| E | 0071770 | biological_process | DIM/DIP cell wall layer assembly |
| F | 0005886 | cellular_component | plasma membrane |
| F | 0006629 | biological_process | lipid metabolic process |
| F | 0008126 | molecular_function | acetylesterase activity |
| F | 0008610 | biological_process | lipid biosynthetic process |
| F | 0009058 | biological_process | biosynthetic process |
| F | 0016787 | molecular_function | hydrolase activity |
| F | 0047617 | molecular_function | fatty acyl-CoA hydrolase activity |
| F | 0052167 | biological_process | symbiont-mediated perturbation of host innate immune response |
| F | 0071770 | biological_process | DIM/DIP cell wall layer assembly |
| G | 0005886 | cellular_component | plasma membrane |
| G | 0006629 | biological_process | lipid metabolic process |
| G | 0008126 | molecular_function | acetylesterase activity |
| G | 0008610 | biological_process | lipid biosynthetic process |
| G | 0009058 | biological_process | biosynthetic process |
| G | 0016787 | molecular_function | hydrolase activity |
| G | 0047617 | molecular_function | fatty acyl-CoA hydrolase activity |
| G | 0052167 | biological_process | symbiont-mediated perturbation of host innate immune response |
| G | 0071770 | biological_process | DIM/DIP cell wall layer assembly |
| H | 0005886 | cellular_component | plasma membrane |
| H | 0006629 | biological_process | lipid metabolic process |
| H | 0008126 | molecular_function | acetylesterase activity |
| H | 0008610 | biological_process | lipid biosynthetic process |
| H | 0009058 | biological_process | biosynthetic process |
| H | 0016787 | molecular_function | hydrolase activity |
| H | 0047617 | molecular_function | fatty acyl-CoA hydrolase activity |
| H | 0052167 | biological_process | symbiont-mediated perturbation of host innate immune response |
| H | 0071770 | biological_process | DIM/DIP cell wall layer assembly |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue E9H A 401 |
| Chain | Residue |
| A | HIS36 |
| A | ALA37 |
| A | SER104 |
| A | MET105 |
| A | HIS236 |
| A | MPD402 |
| A | HOH511 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue MPD A 402 |
| Chain | Residue |
| A | SER133 |
| A | ILE185 |
| A | ILE210 |
| A | E9H401 |
| F | ARG139 |
| A | ALA131 |
| A | CYS132 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue MPD A 403 |
| Chain | Residue |
| A | ASP43 |
| A | PHE237 |
| A | ASN240 |
| D | ARG49 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue CA A 404 |
| Chain | Residue |
| A | GLU50 |
| A | LEU243 |
| D | ARG49 |
| D | PHE51 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue MPD B 402 |
| Chain | Residue |
| B | SER104 |
| B | SER133 |
| B | ILE210 |
| B | E9H401 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue MPD B 403 |
| Chain | Residue |
| B | HIS36 |
| B | ASP43 |
| B | PHE237 |
| B | ASN240 |
| B | HOH507 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue CA C 302 |
| Chain | Residue |
| B | HOH553 |
| C | ARG49 |
| C | HOH409 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue MPD C 303 |
| Chain | Residue |
| C | MET108 |
| C | CYS132 |
| C | SER133 |
| C | E9H301 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue MPD C 304 |
| Chain | Residue |
| C | HIS36 |
| C | ASP43 |
| C | ASN240 |
| C | HOH412 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue MPD D 302 |
| Chain | Residue |
| D | MET108 |
| D | ALA131 |
| D | SER133 |
| D | ILE138 |
| D | ILE210 |
| D | E9H301 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue MPD D 303 |
| Chain | Residue |
| D | ASP43 |
| D | TYR44 |
| D | PHE237 |
| D | ASN240 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue MPD E 302 |
| Chain | Residue |
| E | SER104 |
| E | MET105 |
| E | ALA131 |
| E | SER133 |
| E | ARG139 |
| E | ILE210 |
| E | E9H301 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue MPD F 302 |
| Chain | Residue |
| F | SER104 |
| F | MET108 |
| F | CYS132 |
| F | SER133 |
| F | ILE138 |
| F | ILE185 |
| F | ILE210 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue MPD F 303 |
| Chain | Residue |
| F | HIS36 |
| F | ASP43 |
| F | TYR44 |
| F | PHE237 |
| F | ASN240 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue MPD G 302 |
| Chain | Residue |
| G | SER104 |
| G | ALA131 |
| G | SER133 |
| G | ILE210 |
| site_id | AD7 |
| Number of Residues | 11 |
| Details | binding site for Di-peptide E9H B 401 and SER B 104 |
| Chain | Residue |
| B | HIS36 |
| B | ALA37 |
| B | HIS103 |
| B | MET105 |
| B | GLY106 |
| B | GLY107 |
| B | SER130 |
| B | ALA131 |
| B | CYS132 |
| B | HIS236 |
| B | MPD402 |
| site_id | AD8 |
| Number of Residues | 11 |
| Details | binding site for Di-peptide E9H C 301 and SER C 104 |
| Chain | Residue |
| C | HIS36 |
| C | ALA37 |
| C | HIS103 |
| C | MET105 |
| C | GLY106 |
| C | GLY107 |
| C | SER130 |
| C | ALA131 |
| C | CYS132 |
| C | HIS236 |
| C | MPD303 |
| site_id | AD9 |
| Number of Residues | 11 |
| Details | binding site for Di-peptide E9H D 301 and SER D 104 |
| Chain | Residue |
| D | HIS103 |
| D | MET105 |
| D | GLY106 |
| D | GLY107 |
| D | SER130 |
| D | ALA131 |
| D | CYS132 |
| D | HIS236 |
| D | MPD302 |
| D | HIS36 |
| D | ALA37 |
| site_id | AE1 |
| Number of Residues | 12 |
| Details | binding site for Di-peptide E9H E 301 and SER E 104 |
| Chain | Residue |
| E | HIS36 |
| E | ALA37 |
| E | HIS103 |
| E | MET105 |
| E | GLY106 |
| E | GLY107 |
| E | SER130 |
| E | ALA131 |
| E | CYS132 |
| E | HIS236 |
| E | MPD302 |
| E | HOH405 |
| site_id | AE2 |
| Number of Residues | 12 |
| Details | binding site for Di-peptide E9H F 301 and SER F 104 |
| Chain | Residue |
| F | HIS36 |
| F | ALA37 |
| F | HIS103 |
| F | MET105 |
| F | GLY106 |
| F | GLY107 |
| F | SER130 |
| F | ALA131 |
| F | CYS132 |
| F | HIS236 |
| F | MPD302 |
| F | HOH410 |
| site_id | AE3 |
| Number of Residues | 11 |
| Details | binding site for Di-peptide E9H G 301 and SER G 104 |
| Chain | Residue |
| G | HIS36 |
| G | ALA37 |
| G | HIS103 |
| G | MET105 |
| G | GLY106 |
| G | GLY107 |
| G | SER130 |
| G | ALA131 |
| G | CYS132 |
| G | HIS236 |
| G | MPD302 |
| site_id | AE4 |
| Number of Residues | 11 |
| Details | binding site for Di-peptide E9H H 301 and SER H 104 |
| Chain | Residue |
| D | ARG157 |
| H | HIS36 |
| H | ALA37 |
| H | HIS103 |
| H | MET105 |
| H | GLY106 |
| H | GLY107 |
| H | SER130 |
| H | ALA131 |
| H | CYS132 |
| H | HIS236 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"30292819","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
