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6FUJ

Complement factor D in complex with the inhibitor N-(3'-(aminomethyl)-[1,1'-biphenyl]-3-yl)-3-methylbutanamide

Functional Information from GO Data
ChainGOidnamespacecontents
A0002376biological_processimmune system process
A0004252molecular_functionserine-type endopeptidase activity
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006508biological_processproteolysis
A0006956biological_processcomplement activation
A0006957biological_processcomplement activation, alternative pathway
A0008233molecular_functionpeptidase activity
A0008236molecular_functionserine-type peptidase activity
A0009617biological_processresponse to bacterium
A0016787molecular_functionhydrolase activity
A0031093cellular_componentplatelet alpha granule lumen
A0034774cellular_componentsecretory granule lumen
A0045087biological_processinnate immune response
A0070062cellular_componentextracellular exosome
A1904813cellular_componentficolin-1-rich granule lumen
B0002376biological_processimmune system process
B0004252molecular_functionserine-type endopeptidase activity
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0006508biological_processproteolysis
B0006956biological_processcomplement activation
B0006957biological_processcomplement activation, alternative pathway
B0008233molecular_functionpeptidase activity
B0008236molecular_functionserine-type peptidase activity
B0009617biological_processresponse to bacterium
B0016787molecular_functionhydrolase activity
B0031093cellular_componentplatelet alpha granule lumen
B0034774cellular_componentsecretory granule lumen
B0045087biological_processinnate immune response
B0070062cellular_componentextracellular exosome
B1904813cellular_componentficolin-1-rich granule lumen
C0002376biological_processimmune system process
C0004252molecular_functionserine-type endopeptidase activity
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0006508biological_processproteolysis
C0006956biological_processcomplement activation
C0006957biological_processcomplement activation, alternative pathway
C0008233molecular_functionpeptidase activity
C0008236molecular_functionserine-type peptidase activity
C0009617biological_processresponse to bacterium
C0016787molecular_functionhydrolase activity
C0031093cellular_componentplatelet alpha granule lumen
C0034774cellular_componentsecretory granule lumen
C0045087biological_processinnate immune response
C0070062cellular_componentextracellular exosome
C1904813cellular_componentficolin-1-rich granule lumen
D0002376biological_processimmune system process
D0004252molecular_functionserine-type endopeptidase activity
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0006508biological_processproteolysis
D0006956biological_processcomplement activation
D0006957biological_processcomplement activation, alternative pathway
D0008233molecular_functionpeptidase activity
D0008236molecular_functionserine-type peptidase activity
D0009617biological_processresponse to bacterium
D0016787molecular_functionhydrolase activity
D0031093cellular_componentplatelet alpha granule lumen
D0034774cellular_componentsecretory granule lumen
D0045087biological_processinnate immune response
D0070062cellular_componentextracellular exosome
D1904813cellular_componentficolin-1-rich granule lumen
E0002376biological_processimmune system process
E0004252molecular_functionserine-type endopeptidase activity
E0005576cellular_componentextracellular region
E0005615cellular_componentextracellular space
E0006508biological_processproteolysis
E0006956biological_processcomplement activation
E0006957biological_processcomplement activation, alternative pathway
E0008233molecular_functionpeptidase activity
E0008236molecular_functionserine-type peptidase activity
E0009617biological_processresponse to bacterium
E0016787molecular_functionhydrolase activity
E0031093cellular_componentplatelet alpha granule lumen
E0034774cellular_componentsecretory granule lumen
E0045087biological_processinnate immune response
E0070062cellular_componentextracellular exosome
E1904813cellular_componentficolin-1-rich granule lumen
F0002376biological_processimmune system process
F0004252molecular_functionserine-type endopeptidase activity
F0005576cellular_componentextracellular region
F0005615cellular_componentextracellular space
F0006508biological_processproteolysis
F0006956biological_processcomplement activation
F0006957biological_processcomplement activation, alternative pathway
F0008233molecular_functionpeptidase activity
F0008236molecular_functionserine-type peptidase activity
F0009617biological_processresponse to bacterium
F0016787molecular_functionhydrolase activity
F0031093cellular_componentplatelet alpha granule lumen
F0034774cellular_componentsecretory granule lumen
F0045087biological_processinnate immune response
F0070062cellular_componentextracellular exosome
F1904813cellular_componentficolin-1-rich granule lumen
Functional Information from PDB Data
site_idAC1
Number of Residues12
Detailsbinding site for residue E8B A 301
ChainResidue
APRO96
AVAL219
AHOH423
AHOH433
AASP189
ASER190
ACYS191
ALYS192
ASER195
ASER215
AARG218
AARG218

site_idAC2
Number of Residues18
Detailsbinding site for residue E8B B 301
ChainResidue
BLEU41
BHIS57
BCYS58
BASP189
BSER190
BCYS191
BLYS192
BSER195
BSER215
BARG218
BVAL219
BCYS220
BHOH416
BHOH418
BHOH453
CASP61
CPRO96
CARG218

site_idAC3
Number of Residues14
Detailsbinding site for residue E8B C 301
ChainResidue
BASP61
BPRO96
BARG218
CHIS57
CASP189
CSER190
CCYS191
CLYS192
CSER195
CSER215
CARG218
CVAL219
CHOH403
CHOH408

Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LSAAHC
ChainResidueDetails
ALEU53-CYS58

site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. DSckGDSGGPLV
ChainResidueDetails
AASP189-VAL200

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues18
DetailsACT_SITE: Charge relay system
ChainResidueDetails
AHIS57
DHIS57
DASP102
DSER195
EHIS57
EASP102
ESER195
FHIS57
FASP102
FSER195
AASP102
ASER195
BHIS57
BASP102
BSER195
CHIS57
CASP102
CSER195

218853

건을2024-04-24부터공개중

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