6FTW
Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-048
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
A | 0007165 | biological_process | signal transduction |
A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
B | 0007165 | biological_process | signal transduction |
B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
C | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
C | 0007165 | biological_process | signal transduction |
C | 0008081 | molecular_function | phosphoric diester hydrolase activity |
D | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
D | 0007165 | biological_process | signal transduction |
D | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 6 |
Details | binding site for residue ZN A 501 |
Chain | Residue |
A | HIS164 |
A | HIS200 |
A | ASP201 |
A | ASP318 |
A | HOH626 |
A | HOH649 |
site_id | AC2 |
Number of Residues | 6 |
Details | binding site for residue MG A 502 |
Chain | Residue |
A | HOH628 |
A | HOH688 |
A | HOH717 |
A | ASP201 |
A | HOH613 |
A | HOH626 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue EDO A 503 |
Chain | Residue |
A | SER208 |
A | PRO356 |
A | CYS358 |
A | E6Z517 |
A | HOH618 |
site_id | AC4 |
Number of Residues | 5 |
Details | binding site for residue EDO A 504 |
Chain | Residue |
A | ASN115 |
A | ALA155 |
A | ASN161 |
A | ASN162 |
A | ARG335 |
site_id | AC5 |
Number of Residues | 5 |
Details | binding site for residue EDO A 505 |
Chain | Residue |
A | THR186 |
A | GLU189 |
A | SER259 |
A | MET263 |
A | EDO512 |
site_id | AC6 |
Number of Residues | 6 |
Details | binding site for residue EDO A 506 |
Chain | Residue |
A | GLU218 |
A | HOH722 |
C | HIS152 |
C | LYS239 |
C | LEU240 |
C | HOH614 |
site_id | AC7 |
Number of Residues | 4 |
Details | binding site for residue EDO A 507 |
Chain | Residue |
A | LEU175 |
A | THR178 |
A | TRP384 |
A | ASP391 |
site_id | AC8 |
Number of Residues | 3 |
Details | binding site for residue EDO A 508 |
Chain | Residue |
A | THR134 |
A | LYS136 |
A | EDO509 |
site_id | AC9 |
Number of Residues | 5 |
Details | binding site for residue EDO A 509 |
Chain | Residue |
A | THR134 |
A | PHE135 |
A | ASN251 |
A | GLN256 |
A | EDO508 |
site_id | AD1 |
Number of Residues | 4 |
Details | binding site for residue EDO A 510 |
Chain | Residue |
A | HIS152 |
A | GLU243 |
C | SER217 |
C | ARG350 |
site_id | AD2 |
Number of Residues | 6 |
Details | binding site for residue EDO A 511 |
Chain | Residue |
A | PHE238 |
A | PHE249 |
A | ARG257 |
A | ARG261 |
A | HOH633 |
A | HOH642 |
site_id | AD3 |
Number of Residues | 6 |
Details | binding site for residue EDO A 512 |
Chain | Residue |
A | SER259 |
A | LYS262 |
A | TYR303 |
A | EDO505 |
A | EDO514 |
A | HOH660 |
site_id | AD4 |
Number of Residues | 7 |
Details | binding site for residue EDO A 513 |
Chain | Residue |
A | ARG116 |
A | GLU150 |
A | ASP151 |
A | TYR153 |
A | HOH604 |
A | HOH719 |
C | EDO510 |
site_id | AD5 |
Number of Residues | 3 |
Details | binding site for residue EDO A 514 |
Chain | Residue |
A | EDO512 |
A | HOH602 |
A | HOH721 |
site_id | AD6 |
Number of Residues | 9 |
Details | binding site for residue EPE A 515 |
Chain | Residue |
A | HIS105 |
A | VAL106 |
A | PHE107 |
A | ARG108 |
A | GLU111 |
A | GLN327 |
A | LEU328 |
A | GLN331 |
A | HOH691 |
site_id | AD7 |
Number of Residues | 5 |
Details | binding site for residue EDO A 516 |
Chain | Residue |
A | LYS262 |
A | ASP266 |
A | HOH700 |
B | HOH619 |
B | HOH655 |
site_id | AD8 |
Number of Residues | 15 |
Details | binding site for residue E6Z A 517 |
Chain | Residue |
A | HOH717 |
A | MET273 |
A | ASP318 |
A | LEU319 |
A | THR333 |
A | ILE336 |
A | MET337 |
A | MET357 |
A | SER368 |
A | GLN369 |
A | PHE372 |
A | ILE376 |
A | EDO503 |
A | HOH618 |
A | HOH693 |
site_id | AD9 |
Number of Residues | 6 |
Details | binding site for residue ZN B 501 |
Chain | Residue |
B | HIS164 |
B | HIS200 |
B | ASP201 |
B | ASP318 |
B | HOH626 |
B | HOH673 |
site_id | AE1 |
Number of Residues | 6 |
Details | binding site for residue MG B 502 |
Chain | Residue |
B | ASP201 |
B | HOH614 |
B | HOH626 |
B | HOH646 |
B | HOH654 |
B | HOH658 |
site_id | AE2 |
Number of Residues | 3 |
Details | binding site for residue EDO B 503 |
Chain | Residue |
B | SER208 |
B | PRO356 |
B | HOH630 |
site_id | AE3 |
Number of Residues | 5 |
Details | binding site for residue EDO B 504 |
Chain | Residue |
B | GLU218 |
B | EDO507 |
B | HOH632 |
C | MET222 |
D | LYS239 |
site_id | AE4 |
Number of Residues | 4 |
Details | binding site for residue EDO B 505 |
Chain | Residue |
B | ASN115 |
B | ALA155 |
B | ASN162 |
B | ARG335 |
site_id | AE5 |
Number of Residues | 6 |
Details | binding site for residue EDO B 506 |
Chain | Residue |
B | PHE211 |
B | ASN214 |
B | GLU347 |
B | MET352 |
B | GLU353 |
B | SER355 |
site_id | AE6 |
Number of Residues | 3 |
Details | binding site for residue EDO B 507 |
Chain | Residue |
B | GLU218 |
B | EDO504 |
D | LYS239 |
site_id | AE7 |
Number of Residues | 8 |
Details | binding site for residue EPE B 508 |
Chain | Residue |
B | HIS105 |
B | VAL106 |
B | PHE107 |
B | ARG108 |
B | GLU111 |
B | GLN327 |
B | LEU328 |
B | GLN331 |
site_id | AE8 |
Number of Residues | 11 |
Details | binding site for residue E6Z B 509 |
Chain | Residue |
B | MET273 |
B | ASP318 |
B | ILE336 |
B | MET337 |
B | MET357 |
B | VAL365 |
B | SER368 |
B | GLN369 |
B | PHE372 |
B | HOH671 |
B | HOH673 |
site_id | AE9 |
Number of Residues | 6 |
Details | binding site for residue ZN C 501 |
Chain | Residue |
C | HIS164 |
C | HIS200 |
C | ASP201 |
C | ASP318 |
C | HOH625 |
C | HOH658 |
site_id | AF1 |
Number of Residues | 6 |
Details | binding site for residue MG C 502 |
Chain | Residue |
C | ASP201 |
C | HOH607 |
C | HOH625 |
C | HOH645 |
C | HOH657 |
C | HOH675 |
site_id | AF2 |
Number of Residues | 4 |
Details | binding site for residue EDO C 503 |
Chain | Residue |
C | PHE249 |
C | ARG257 |
C | HOH605 |
C | HOH653 |
site_id | AF3 |
Number of Residues | 4 |
Details | binding site for residue EDO C 504 |
Chain | Residue |
C | LEU175 |
C | THR178 |
C | TRP384 |
C | ALA392 |
site_id | AF4 |
Number of Residues | 3 |
Details | binding site for residue EDO C 505 |
Chain | Residue |
A | LYS239 |
B | MET222 |
C | GLU218 |
site_id | AF5 |
Number of Residues | 3 |
Details | binding site for residue EDO C 506 |
Chain | Residue |
C | THR148 |
C | HIS152 |
C | GLU243 |
site_id | AF6 |
Number of Residues | 5 |
Details | binding site for residue EDO C 507 |
Chain | Residue |
C | ASN115 |
C | ARG116 |
C | GLU150 |
C | ASP151 |
C | TYR153 |
site_id | AF7 |
Number of Residues | 3 |
Details | binding site for residue EDO C 508 |
Chain | Residue |
C | PRO356 |
C | E6Z512 |
C | HOH638 |
site_id | AF8 |
Number of Residues | 3 |
Details | binding site for residue EDO C 509 |
Chain | Residue |
C | LYS262 |
C | ASP266 |
D | ASP225 |
site_id | AF9 |
Number of Residues | 5 |
Details | binding site for residue EDO C 510 |
Chain | Residue |
A | GLY114 |
A | ASN115 |
A | EDO513 |
C | ARG342 |
C | HOH619 |
site_id | AG1 |
Number of Residues | 8 |
Details | binding site for residue EPE C 511 |
Chain | Residue |
C | HIS105 |
C | VAL106 |
C | PHE107 |
C | ARG108 |
C | GLU111 |
C | GLN327 |
C | LEU328 |
C | GLN331 |
site_id | AG2 |
Number of Residues | 12 |
Details | binding site for residue E6Z C 512 |
Chain | Residue |
C | HIS160 |
C | MET273 |
C | LEU319 |
C | ILE336 |
C | MET337 |
C | MET357 |
C | SER368 |
C | GLN369 |
C | PHE372 |
C | EDO508 |
C | HOH638 |
C | HOH656 |
site_id | AG3 |
Number of Residues | 3 |
Details | binding site for residue EDO C 513 |
Chain | Residue |
C | ASN214 |
C | GLU353 |
D | GLN258 |
site_id | AG4 |
Number of Residues | 6 |
Details | binding site for residue ZN D 501 |
Chain | Residue |
D | HIS164 |
D | HIS200 |
D | ASP201 |
D | ASP318 |
D | HOH617 |
D | HOH654 |
site_id | AG5 |
Number of Residues | 6 |
Details | binding site for residue MG D 502 |
Chain | Residue |
D | ASP201 |
D | HOH617 |
D | HOH652 |
D | HOH671 |
D | HOH689 |
D | HOH709 |
site_id | AG6 |
Number of Residues | 4 |
Details | binding site for residue EDO D 503 |
Chain | Residue |
D | SER294 |
D | SER295 |
D | HOH609 |
D | HOH660 |
site_id | AG7 |
Number of Residues | 4 |
Details | binding site for residue EDO D 504 |
Chain | Residue |
D | PHE340 |
D | PRO356 |
D | CYS358 |
D | E6Z516 |
site_id | AG8 |
Number of Residues | 5 |
Details | binding site for residue EDO D 505 |
Chain | Residue |
D | PHE238 |
D | ARG257 |
D | ARG261 |
D | HOH647 |
D | HOH672 |
site_id | AG9 |
Number of Residues | 4 |
Details | binding site for residue EDO D 506 |
Chain | Residue |
C | HOH621 |
D | LYS262 |
D | ASP266 |
D | HOH657 |
site_id | AH1 |
Number of Residues | 4 |
Details | binding site for residue EDO D 507 |
Chain | Residue |
D | ASN115 |
D | ALA155 |
D | ASN161 |
D | ASN162 |
site_id | AH2 |
Number of Residues | 6 |
Details | binding site for residue EDO D 508 |
Chain | Residue |
D | LEU175 |
D | THR178 |
D | TRP384 |
D | VAL388 |
D | ASP391 |
D | HOH662 |
site_id | AH3 |
Number of Residues | 6 |
Details | binding site for residue EDO D 509 |
Chain | Residue |
D | GLN250 |
D | LEU252 |
D | THR253 |
D | ARG257 |
D | HOH632 |
D | HOH728 |
site_id | AH4 |
Number of Residues | 4 |
Details | binding site for residue EDO D 510 |
Chain | Residue |
D | ARG129 |
D | LEU131 |
D | ASP187 |
D | ILE190 |
site_id | AH5 |
Number of Residues | 1 |
Details | binding site for residue EDO D 511 |
Chain | Residue |
D | GLU182 |
site_id | AH6 |
Number of Residues | 1 |
Details | binding site for residue EDO D 512 |
Chain | Residue |
D | GLN393 |
site_id | AH7 |
Number of Residues | 1 |
Details | binding site for residue EDO D 513 |
Chain | Residue |
D | ASP98 |
site_id | AH8 |
Number of Residues | 7 |
Details | binding site for residue EPE D 514 |
Chain | Residue |
C | ASP394 |
D | HIS105 |
D | VAL106 |
D | PHE107 |
D | ARG108 |
D | LEU328 |
D | GLN331 |
site_id | AH9 |
Number of Residues | 2 |
Details | binding site for residue EDO D 515 |
Chain | Residue |
D | HIS152 |
D | GLU243 |
site_id | AI1 |
Number of Residues | 10 |
Details | binding site for residue E6Z D 516 |
Chain | Residue |
D | MET273 |
D | ASP318 |
D | LEU319 |
D | ILE336 |
D | MET337 |
D | MET357 |
D | SER368 |
D | GLN369 |
D | PHE372 |
D | EDO504 |
Functional Information from PROSITE/UniProt
site_id | PS00126 |
Number of Residues | 12 |
Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF |
Chain | Residue | Details |
A | HIS200-PHE211 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | ACT_SITE: Proton donor => ECO:0000250|UniProtKB:Q07343 |
Chain | Residue | Details |
A | HIS160 | |
B | HIS160 | |
C | HIS160 | |
D | HIS160 |
site_id | SWS_FT_FI2 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7 |
Chain | Residue | Details |
A | HIS160 | |
D | HIS160 | |
D | ASN321 | |
D | GLN369 | |
A | ASN321 | |
A | GLN369 | |
B | HIS160 | |
B | ASN321 | |
B | GLN369 | |
C | HIS160 | |
C | ASN321 | |
C | GLN369 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:2PW3 |
Chain | Residue | Details |
A | HIS164 | |
B | HIS164 | |
C | HIS164 | |
D | HIS164 |
site_id | SWS_FT_FI4 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3 |
Chain | Residue | Details |
A | HIS200 | |
A | ASP318 | |
B | HIS200 | |
B | ASP318 | |
C | HIS200 | |
C | ASP318 | |
D | HIS200 | |
D | ASP318 |
site_id | SWS_FT_FI5 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0007744|PDB:1PTW |
Chain | Residue | Details |
A | ASP201 | |
A | PHE372 | |
B | ASP201 | |
B | PHE372 | |
C | ASP201 | |
C | PHE372 | |
D | ASP201 | |
D | PHE372 |
site_id | SWS_FT_FI6 |
Number of Residues | 8 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) |
Chain | Residue | Details |
A | LYS85 | |
B | LYS85 | |
C | LYS85 | |
D | LYS85 |