6FTV

X-ray structure of human heavy chain ferritin in complex with NAMI A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004322	molecular_function	ferroxidase activity
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005776	cellular_component	autophagosome
A	0005829	cellular_component	cytosol
A	0006826	biological_process	iron ion transport
A	0006879	biological_process	intracellular iron ion homeostasis
A	0006955	biological_process	immune response
A	0008198	molecular_function	ferrous iron binding
A	0008199	molecular_function	ferric iron binding
A	0008285	biological_process	negative regulation of cell population proliferation
A	0016491	molecular_function	oxidoreductase activity
A	0031410	cellular_component	cytoplasmic vesicle
A	0042802	molecular_function	identical protein binding
A	0044754	cellular_component	autolysosome
A	0046872	molecular_function	metal ion binding
A	0048147	biological_process	negative regulation of fibroblast proliferation
A	0070062	cellular_component	extracellular exosome
A	0070288	cellular_component	ferritin complex
A	0110076	biological_process	negative regulation of ferroptosis
A	0140315	molecular_function	iron ion sequestering activity
A	1904724	cellular_component	tertiary granule lumen
A	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue CL A 201

Chain	Residue
A	HIS173
A	HIS173
A	HIS173
A	HIS173

---

site_id	AC2
Number of Residues	4
Details	binding site for residue CL A 202

Chain	Residue
A	GLN83
A	ASP84
A	LYS86
A	HOH579

---

site_id	AC3
Number of Residues	4
Details	binding site for residue CL A 203

Chain	Residue
A	HOH399
A	HOH413
A	HOH522
A	GLN75

---

site_id	AC4
Number of Residues	3
Details	binding site for residue CL A 204

Chain	Residue
A	ARG9
A	ASN11
A	TYR12

---

site_id	AC5
Number of Residues	2
Details	binding site for residue CL A 205

Chain	Residue
A	GLN14
A	HOH518

---

site_id	AC6
Number of Residues	4
Details	binding site for residue CL A 206

Chain	Residue
A	ASN139
A	GLU140
A	LYS143
A	HOH580

---

site_id	AC7
Number of Residues	2
Details	binding site for residue CL A 207

Chain	Residue
A	GLN75
A	ASN139

---

site_id	AC8
Number of Residues	6
Details	binding site for residue MG A 208

Chain	Residue
A	GLU27
A	GLU62
A	HIS65
A	HOH312
A	HOH326
A	HOH365

---

site_id	AC9
Number of Residues	2
Details	binding site for residue MG A 209

Chain	Residue
A	CYS90
A	HOH640

---

site_id	AD1
Number of Residues	6
Details	binding site for residue MG A 210

Chain	Residue
A	HOH310
A	HOH310
A	HOH310
A	HOH533
A	HOH533
A	HOH533

---

site_id	AD2
Number of Residues	8
Details	binding site for residue MG A 211

Chain	Residue
A	HOH329
A	HOH329
A	HOH337
A	HOH337
A	HOH579
A	HOH579
A	HOH641
A	HOH641

---

site_id	AD3
Number of Residues	8
Details	binding site for residue MG A 212

Chain	Residue
A	ASP150
A	MG215
A	HOH396
A	HOH415
A	HOH475
A	HOH504
A	HOH592
A	HOH601

---

site_id	AD4
Number of Residues	6
Details	binding site for residue MG A 213

Chain	Residue
A	HOH376
A	HOH408
A	HOH427
A	HOH478
A	HOH580
A	HOH620

---

site_id	AD5
Number of Residues	5
Details	binding site for residue MG A 214

Chain	Residue
A	CYS102
A	HOH548
A	HOH563
A	HOH573
A	HOH651

---

site_id	AD6
Number of Residues	8
Details	binding site for residue MG A 215

Chain	Residue
A	ASP42
A	LYS146
A	MG212
A	HOH320
A	HOH378
A	HOH396
A	HOH459
A	HOH592

---

site_id	AD7
Number of Residues	6
Details	binding site for residue MG A 216

Chain	Residue
A	GLN58
A	GLU61
A	HOH307
A	HOH342
A	HOH432
A	HOH539

---

site_id	AD8
Number of Residues	7
Details	binding site for residue RU A 217

Chain	Residue
A	HIS105
A	HOH301
A	HOH420
A	HOH488
A	HOH523
A	HOH531
A	HOH637

---

Functional Information from PROSITE/UniProt

site_id	PS00204
Number of Residues	21
Details	FERRITIN_2 Ferritin iron-binding regions signature 2. DphLCDFIEthYLneqvkaIK

Chain	Residue	Details
A	ASP126-LYS146

---

site_id	PS00540
Number of Residues	19
Details	FERRITIN_1 Ferritin iron-binding regions signature 1. EeREhaEKLMklQNqRgGR

Chain	Residue	Details
A	GLU61-ARG79

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	149
Details	Domain: {"description":"Ferritin-like diiron","evidences":[{"source":"PROSITE-ProRule","id":"PRU00085","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"1992356","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FHA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00085","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Site: {"description":"Essential for association with cargo receptor NCOA4","evidences":[{"source":"PubMed","id":"26436293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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