Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 1001 |
| Chain | Residue |
| A | ASP710 |
| A | HOH1114 |
| A | HOH1120 |
| A | HOH1167 |
| A | HOH1169 |
| A | HOH1230 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue ZN A 1002 |
| Chain | Residue |
| A | ASP822 |
| A | HOH1120 |
| A | HOH1208 |
| A | HIS673 |
| A | HIS709 |
| A | ASP710 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1003 |
| Chain | Residue |
| A | GLY688 |
| A | ASN689 |
| A | GLU692 |
| A | LEU894 |
| A | GLN895 |
| A | GLY896 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1004 |
| Chain | Residue |
| A | ALA909 |
| A | ARG913 |
| A | GLU916 |
| A | HOH1204 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 1005 |
| Chain | Residue |
| A | LYS723 |
| A | GLN847 |
| A | GLU851 |
| A | VAL858 |
| A | LEU859 |
| A | PHE862 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1006 |
| Chain | Residue |
| A | PHE615 |
| A | ARG618 |
| A | PRO667 |
| A | ASN670 |
| A | TRP836 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 1007 |
| Chain | Residue |
| A | LYS623 |
| A | PRO624 |
| A | LEU625 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1008 |
| Chain | Residue |
| A | LYS591 |
| A | ARG594 |
| A | GLU650 |
| A | EDO1013 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 1009 |
| Chain | Residue |
| A | GLN643 |
| A | ASP649 |
| B | LEU697 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1010 |
| Chain | Residue |
| A | ARG664 |
| A | ASN665 |
| B | ALA909 |
| B | ARG913 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 1011 |
| Chain | Residue |
| A | ASN665 |
| A | VAL666 |
| A | PRO667 |
| A | HOH1177 |
| B | ARG903 |
| B | SER906 |
| B | EDO1004 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 1012 |
| Chain | Residue |
| A | SER775 |
| A | ASP778 |
| A | ARG811 |
| A | HOH1180 |
| A | HOH1226 |
| site_id | AD4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 1013 |
| Chain | Residue |
| A | TYR633 |
| A | ASP649 |
| A | EDO1008 |
| B | LYS644 |
| site_id | AD5 |
| Number of Residues | 1 |
| Details | binding site for residue EDO A 1014 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue GAI A 1015 |
| Chain | Residue |
| A | ASP712 |
| A | MET714 |
| A | LEU728 |
| A | LEU741 |
| A | HIS744 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue GAI A 1016 |
| Chain | Residue |
| A | ASP606 |
| A | ASP609 |
| A | HOH1141 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue GAI A 1017 |
| Chain | Residue |
| A | GLY638 |
| A | SER639 |
| A | HIS682 |
| A | HOH1225 |
| site_id | AD9 |
| Number of Residues | 8 |
| Details | binding site for residue GAI A 1018 |
| Chain | Residue |
| A | PHE645 |
| A | GLY646 |
| A | GLY763 |
| A | HOH1189 |
| B | LYS693 |
| B | PHE809 |
| B | HIS810 |
| B | EDO1005 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue GAI A 1019 |
| Chain | Residue |
| A | THR695 |
| A | GLU696 |
| A | HOH1112 |
| A | HOH1135 |
| B | SER804 |
| site_id | AE2 |
| Number of Residues | 3 |
| Details | binding site for residue GAI A 1020 |
| Chain | Residue |
| A | MET812 |
| A | GLU815 |
| A | GAI1021 |
| site_id | AE3 |
| Number of Residues | 3 |
| Details | binding site for residue GAI A 1021 |
| Chain | Residue |
| A | ASP778 |
| A | GLU815 |
| A | GAI1020 |
| site_id | AE4 |
| Number of Residues | 4 |
| Details | binding site for residue GAI A 1022 |
| Chain | Residue |
| A | TYR845 |
| A | MET861 |
| A | ASN867 |
| A | E6Z1026 |
| site_id | AE5 |
| Number of Residues | 6 |
| Details | binding site for residue FMT A 1023 |
| Chain | Residue |
| A | LEU753 |
| A | SER754 |
| A | PRO756 |
| A | ASP759 |
| A | ASP762 |
| A | HOH1147 |
| site_id | AE6 |
| Number of Residues | 4 |
| Details | binding site for residue FMT A 1024 |
| Chain | Residue |
| A | SER639 |
| A | LEU641 |
| A | LYS644 |
| A | HOH1126 |
| site_id | AE7 |
| Number of Residues | 4 |
| Details | binding site for residue FMT A 1025 |
| Chain | Residue |
| A | GLU692 |
| A | LYS693 |
| A | LEU694 |
| A | HIS810 |
| site_id | AE8 |
| Number of Residues | 8 |
| Details | binding site for residue E6Z A 1026 |
| Chain | Residue |
| A | MET785 |
| A | VAL840 |
| A | PHE844 |
| A | MET861 |
| A | GLY873 |
| A | GLN874 |
| A | PHE877 |
| A | GAI1022 |
| site_id | AE9 |
| Number of Residues | 3 |
| Details | binding site for residue FMT A 1027 |
| Chain | Residue |
| A | ARG769 |
| A | THR770 |
| B | GLU725 |
| site_id | AF1 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 1001 |
| Chain | Residue |
| B | ASP710 |
| B | HOH1125 |
| B | HOH1135 |
| B | HOH1158 |
| B | HOH1159 |
| B | HOH1239 |
| site_id | AF2 |
| Number of Residues | 6 |
| Details | binding site for residue ZN B 1002 |
| Chain | Residue |
| B | HIS673 |
| B | HIS709 |
| B | ASP710 |
| B | ASP822 |
| B | HOH1135 |
| B | HOH1203 |
| site_id | AF3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 1003 |
| Chain | Residue |
| B | PHE605 |
| B | ASP606 |
| B | ASP609 |
| B | GLU611 |
| B | PHE612 |
| B | HOH1213 |
| site_id | AF4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 1004 |
| Chain | Residue |
| A | EDO1011 |
| B | TRP899 |
| B | ARG903 |
| B | SER906 |
| site_id | AF5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 1005 |
| Chain | Residue |
| A | LEU764 |
| A | GLU765 |
| A | GLU768 |
| A | GAI1018 |
| B | GLN802 |
| B | GLU806 |
| site_id | AF6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 1006 |
| Chain | Residue |
| B | GLU698 |
| B | LEU771 |
| B | HIS810 |
| B | HOH1123 |
| site_id | AF7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 1007 |
| Chain | Residue |
| B | GLY688 |
| B | ASN689 |
| B | LEU894 |
| B | GLN895 |
| B | GLY896 |
| site_id | AF8 |
| Number of Residues | 1 |
| Details | binding site for residue EDO B 1008 |
| site_id | AF9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 1009 |
| Chain | Residue |
| B | LEU722 |
| B | GLY729 |
| B | SER733 |
| site_id | AG1 |
| Number of Residues | 4 |
| Details | binding site for residue GAI B 1010 |
| Chain | Residue |
| A | HOH1183 |
| B | LEU694 |
| B | HOH1151 |
| B | HOH1192 |
| site_id | AG2 |
| Number of Residues | 7 |
| Details | binding site for residue GAI B 1011 |
| Chain | Residue |
| B | LEU753 |
| B | SER754 |
| B | ASP759 |
| B | ASP762 |
| B | LEU915 |
| B | ARG918 |
| B | HOH1134 |
| site_id | AG3 |
| Number of Residues | 4 |
| Details | binding site for residue FMT B 1012 |
| Chain | Residue |
| B | ARG618 |
| B | PRO667 |
| B | ASN670 |
| B | TRP836 |
| site_id | AG4 |
| Number of Residues | 9 |
| Details | binding site for residue E6Z B 1013 |
| Chain | Residue |
| B | MET785 |
| B | ASP822 |
| B | VAL840 |
| B | MET861 |
| B | MET868 |
| B | GLY873 |
| B | GLN874 |
| B | HOH1147 |
| B | HOH1242 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHmGlnNsF |
| Chain | Residue | Details |
| A | HIS709-PHE720 | |
