Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| A | 0045454 | biological_process | cell redox homeostasis |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 36 |
| Details | binding site for residue FAD A 601 |
| Chain | Residue |
| A | ILE113 |
| A | THR153 |
| A | CYS154 |
| A | GLY158 |
| A | CYS159 |
| A | LYS162 |
| A | ALA226 |
| A | GLY228 |
| A | ALA256 |
| A | THR257 |
| A | GLY258 |
| A | GLY114 |
| A | TYR296 |
| A | VAL297 |
| A | ARG393 |
| A | GLY432 |
| A | ASP433 |
| A | GLN440 |
| A | LEU441 |
| A | THR442 |
| A | PRO443 |
| A | HIS571 |
| A | GLY115 |
| A | HOH748 |
| A | HOH773 |
| A | HOH812 |
| A | HOH896 |
| A | HOH911 |
| A | HOH921 |
| A | HOH1076 |
| A | GLY116 |
| A | SER117 |
| A | GLY118 |
| A | ASP137 |
| A | TYR138 |
| A | GLY152 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue EPE A 602 |
| Chain | Residue |
| A | ARG322 |
| A | GLY323 |
| A | PHE324 |
| A | ALA481 |
| A | GLY483 |
| A | HOH746 |
| A | HOH912 |
| A | HOH957 |
| A | HOH1001 |
| A | HOH1072 |
| A | HOH1108 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue PGE A 603 |
| Chain | Residue |
| A | ILE319 |
| A | LEU320 |
| A | GLN326 |
| A | GLY333 |
| A | ASP334 |
| A | HOH968 |
| A | HOH1111 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | binding site for residue PGE A 604 |
| Chain | Residue |
| A | TRP10 |
| A | LYS13 |
| A | THR14 |
| A | ASP420 |
| A | TYR429 |
| A | LEU452 |
| A | ARG455 |
| A | LEU456 |
| A | ALA460 |
| A | HOH864 |
| A | HOH997 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue PG4 A 605 |
| Chain | Residue |
| A | ASP488 |
| A | GLU491 |
| A | LYS492 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue PEG A 606 |
| Chain | Residue |
| A | TYR138 |
| A | ASN225 |
| A | THR239 |
| A | ASP240 |
| A | LYS241 |
| A | GLN243 |
| A | HOH1169 |
Functional Information from PROSITE/UniProt
| site_id | PS00076 |
| Number of Residues | 11 |
| Details | PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCVnvGCIP |
| Chain | Residue | Details |
| A | GLY151-PRO161 | |
| site_id | PS00194 |
| Number of Residues | 19 |
| Details | THIOREDOXIN_1 Thioredoxin family active site. VIlFSktTCPYCKkVkdvL |
| Chain | Residue | Details |
| A | VAL20-LEU38 | |
| site_id | PS00195 |
| Number of Residues | 17 |
| Details | GLUTAREDOXIN_1 Glutaredoxin active site. LFskttCPYCkkVkdvL |
| Chain | Residue | Details |
| A | LEU22-LEU38 | |
