Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 301 |
| Chain | Residue |
| A | GLN40 |
| A | ASP41 |
| A | PRO42 |
| A | ALA88 |
| A | THR89 |
| A | LYS107 |
| A | EDO316 |
| A | HOH447 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 302 |
| Chain | Residue |
| A | SER178 |
| A | ASN179 |
| A | LYS180 |
| A | PHE183 |
| A | HOH438 |
| A | SER133 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 303 |
| Chain | Residue |
| A | THR6 |
| A | ILE8 |
| A | ASN24 |
| A | CYS25 |
| A | SER26 |
| A | HOH407 |
| A | HOH409 |
| B | ARG10 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 304 |
| Chain | Residue |
| A | VAL5 |
| A | THR6 |
| A | GLN7 |
| A | GLY103 |
| A | SER104 |
| B | EDO303 |
| B | HOH408 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 305 |
| Chain | Residue |
| A | ALA186 |
| A | PHE189 |
| A | ASN190 |
| A | SER192 |
| A | ILE194 |
| A | HOH494 |
| A | HOH532 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 306 |
| Chain | Residue |
| A | SER67 |
| A | LEU68 |
| A | ASP69 |
| A | ARG74 |
| A | SER75 |
| A | THR76 |
| A | EDO308 |
| A | HOH453 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 307 |
| Chain | Residue |
| A | ALA80 |
| A | EDO315 |
| A | HOH412 |
| A | HOH422 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 308 |
| Chain | Residue |
| A | ARG74 |
| A | THR76 |
| A | TYR78 |
| A | EDO306 |
| A | HOH430 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 309 |
| Chain | Residue |
| A | ASP126 |
| A | SER127 |
| A | LYS128 |
| A | SER130 |
| A | HOH401 |
| A | HOH408 |
| A | HOH410 |
| site_id | AD1 |
| Number of Residues | 10 |
| Details | binding site for residue EDO A 310 |
| Chain | Residue |
| A | PHE27 |
| A | SER72 |
| A | GLY73 |
| A | HOH403 |
| A | HOH405 |
| A | HOH469 |
| A | HOH571 |
| B | THR8 |
| B | PRO9 |
| B | ARG10 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 311 |
| Chain | Residue |
| A | VAL121 |
| A | CYS185 |
| A | ALA186 |
| A | PHE200 |
| A | PRO201 |
| A | HOH414 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 312 |
| Chain | Residue |
| A | SER48 |
| A | LEU49 |
| A | LEU50 |
| A | EDO314 |
| B | PRO102 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 313 |
| Chain | Residue |
| A | ASP131 |
| A | LYS132 |
| A | ASN179 |
| A | HOH404 |
| A | HOH502 |
| A | HOH570 |
| B | GLU124 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 314 |
| Chain | Residue |
| A | LEU50 |
| A | LEU51 |
| A | GLN59 |
| A | EDO312 |
| A | HOH445 |
| B | PRO102 |
| site_id | AD6 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 315 |
| Chain | Residue |
| A | EDO307 |
| A | HOH555 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 316 |
| Chain | Residue |
| A | GLN40 |
| A | EDO301 |
| A | HOH432 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 317 |
| Chain | Residue |
| A | SER130 |
| A | LYS132 |
| B | GLU124 |
| B | ALA126 |
| B | LEU146 |
| B | THR148 |
| site_id | AD9 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 318 |
| Chain | Residue |
| A | ASP41 |
| A | PRO42 |
| A | GLY43 |
| A | LYS44 |
| B | LEU89 |
| B | ARG110 |
| B | HOH461 |
| B | HOH490 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 319 |
| Chain | Residue |
| A | ARG39 |
| A | GLN40 |
| A | ASP41 |
| A | LYS44 |
| A | GLY45 |
| A | THR47 |
| site_id | AE2 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 320 |
| Chain | Residue |
| A | LEU91 |
| A | PHE102 |
| A | GLY103 |
| A | SER104 |
| B | GLY43 |
| B | LEU44 |
| B | EDO319 |
| B | HOH578 |
| site_id | AE3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 301 |
| Chain | Residue |
| B | TRP160 |
| B | LYS164 |
| B | GLU165 |
| B | HOH523 |
| B | HOH608 |
| site_id | AE4 |
| Number of Residues | 10 |
| Details | binding site for residue EDO B 302 |
| Chain | Residue |
| B | TYR11 |
| B | LEU12 |
| B | ILE13 |
| B | HIS154 |
| B | TYR215 |
| B | GLY216 |
| B | THR232 |
| B | HOH403 |
| B | HOH483 |
| B | HOH602 |
| site_id | AE5 |
| Number of Residues | 10 |
| Details | binding site for residue EDO B 303 |
| Chain | Residue |
| A | GLU4 |
| A | EDO304 |
| A | HOH451 |
| B | LEU217 |
| B | GLU219 |
| B | VAL231 |
| B | THR232 |
| B | HOH408 |
| B | HOH427 |
| B | HOH441 |
| site_id | AE6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 304 |
| Chain | Residue |
| B | ARG10 |
| B | ASN107 |
| B | GLY108 |
| B | HOH461 |
| B | HOH490 |
| site_id | AE7 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 305 |
| Chain | Residue |
| A | SER30 |
| A | ALA31 |
| A | LYS70 |
| A | HOH441 |
| B | EDO314 |
| B | HOH412 |
| B | HOH414 |
| site_id | AE8 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 306 |
| Chain | Residue |
| A | PRO9 |
| A | ALA11 |
| B | ARG209 |
| B | ILE234 |
| B | SER236 |
| B | HOH402 |
| B | HOH410 |
| B | HOH580 |
| site_id | AE9 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 307 |
| Chain | Residue |
| B | GLU156 |
| B | SER158 |
| B | GLU165 |
| B | GLN213 |
| B | HOH445 |
| B | HOH462 |
| B | HOH541 |
| site_id | AF1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 308 |
| Chain | Residue |
| B | VAL166 |
| B | HIS167 |
| B | SER168 |
| site_id | AF2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 309 |
| Chain | Residue |
| A | GLY45 |
| A | LEU46 |
| B | PHE105 |
| B | GLY106 |
| B | ASN107 |
| site_id | AF3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 310 |
| Chain | Residue |
| B | SER197 |
| B | THR199 |
| B | PHE200 |
| B | HOH568 |
| B | HOH620 |
| site_id | AF4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 311 |
| Chain | Residue |
| A | ASP118 |
| B | GLN55 |
| B | LYS58 |
| B | HOH598 |
| site_id | AF5 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 312 |
| Chain | Residue |
| B | GLN45 |
| B | PHE46 |
| B | GLY59 |
| B | ASN60 |
| B | HOH404 |
| B | HOH444 |
| B | HOH556 |
| site_id | AF6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 313 |
| Chain | Residue |
| B | VAL161 |
| B | VAL166 |
| B | HOH418 |
| B | HOH453 |
| B | HOH468 |
| B | HOH611 |
| site_id | AF7 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 314 |
| Chain | Residue |
| A | THR28 |
| A | ASP29 |
| A | SER30 |
| B | SER23 |
| B | ARG74 |
| B | EDO305 |
| B | HOH405 |
| B | HOH439 |
| site_id | AF8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 315 |
| Chain | Residue |
| B | ASP116 |
| B | ASN118 |
| B | GLU222 |
| B | TRP223 |
| B | THR224 |
| site_id | AF9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 316 |
| Chain | Residue |
| B | THR39 |
| B | GLN42 |
| B | GLY85 |
| B | HOH495 |
| site_id | AG1 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 317 |
| Chain | Residue |
| B | THR15 |
| B | GLN18 |
| B | LEU117 |
| B | ASP221 |
| B | HOH463 |
| B | HOH466 |
| site_id | AG2 |
| Number of Residues | 9 |
| Details | binding site for residue EDO B 318 |
| Chain | Residue |
| A | HOH545 |
| B | VAL5 |
| B | THR6 |
| B | GLN7 |
| B | ARG10 |
| B | GLY106 |
| B | ASN107 |
| B | GLY108 |
| B | HOH604 |
| site_id | AG3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 319 |
| Chain | Residue |
| A | PHE102 |
| A | GLY103 |
| A | SER104 |
| A | EDO320 |
| B | GLN42 |
| B | LEU44 |
| B | GLN45 |
| site_id | AG4 |
| Number of Residues | 5 |
| Details | binding site for residue PEG B 320 |
| Chain | Residue |
| B | GLN202 |
| B | ALA243 |
| B | ASP244 |
| B | HOH458 |
| B | HOH474 |
| site_id | AG5 |
| Number of Residues | 3 |
| Details | binding site for residue PEG B 321 |
| Chain | Residue |
| B | GLY29 |
| B | PHE96 |
| B | HOH506 |
