Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004791 | molecular_function | thioredoxin-disulfide reductase (NADPH) activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016668 | molecular_function | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor |
| A | 0045454 | biological_process | cell redox homeostasis |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 36 |
| Details | binding site for residue FAD A 601 |
| Chain | Residue |
| A | ILE113 |
| A | THR153 |
| A | CYS154 |
| A | VAL157 |
| A | GLY158 |
| A | CYS159 |
| A | LYS162 |
| A | ALA226 |
| A | LYS227 |
| A | GLY228 |
| A | ALA256 |
| A | GLY114 |
| A | THR257 |
| A | GLY258 |
| A | TYR296 |
| A | ARG393 |
| A | VAL400 |
| A | GLY432 |
| A | ASP433 |
| A | GLN440 |
| A | LEU441 |
| A | THR442 |
| A | GLY115 |
| A | PRO443 |
| A | PHE474 |
| A | HIS571 |
| A | PRO572 |
| A | NA605 |
| A | HOH713 |
| A | HOH714 |
| A | GLY116 |
| A | SER117 |
| A | GLY118 |
| A | ASP137 |
| A | TYR138 |
| A | GLY152 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue PGE A 602 |
| Chain | Residue |
| A | ASP488 |
| A | GLU491 |
| A | LYS492 |
| A | 250606 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue PGE A 603 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue E1T A 604 |
| Chain | Residue |
| A | TYR296 |
| A | PHE324 |
| A | PRO439 |
| A | GLN440 |
| A | LEU441 |
| A | THR471 |
| A | 250606 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 605 |
| Chain | Residue |
| A | THR153 |
| A | GLY258 |
| A | GLU259 |
| A | ARG393 |
| A | ASP433 |
| A | FAD601 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | binding site for residue 250 A 606 |
| Chain | Residue |
| A | GLY323 |
| A | PHE324 |
| A | PRO439 |
| A | TYR466 |
| A | SER467 |
| A | ASN468 |
| A | VAL469 |
| A | LEU484 |
| A | PGE602 |
| A | E1T604 |
| A | HOH707 |
| A | HOH725 |
Functional Information from PROSITE/UniProt
| site_id | PS00076 |
| Number of Residues | 11 |
| Details | PYRIDINE_REDOX_1 Pyridine nucleotide-disulphide oxidoreductases class-I active site. GGtCVnvGCIP |
| Chain | Residue | Details |
| A | GLY151-PRO161 | |
| site_id | PS00194 |
| Number of Residues | 19 |
| Details | THIOREDOXIN_1 Thioredoxin family active site. VIlFSktTCPYCKkVkdvL |
| Chain | Residue | Details |
| A | VAL20-LEU38 | |
| site_id | PS00195 |
| Number of Residues | 17 |
| Details | GLUTAREDOXIN_1 Glutaredoxin active site. LFskttCPYCkkVkdvL |
| Chain | Residue | Details |
| A | LEU22-LEU38 | |
