6FOY
The crystal structure of P.fluorescens Kynurenine 3-monooxygenase (KMO) in complex with competitive inhibitor No. 9
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0004497 | molecular_function | monooxygenase activity |
A | 0004502 | molecular_function | kynurenine 3-monooxygenase activity |
A | 0006569 | biological_process | L-tryptophan catabolic process |
A | 0009435 | biological_process | NAD+ biosynthetic process |
A | 0016174 | molecular_function | NAD(P)H oxidase H2O2-forming activity |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0019363 | biological_process | pyridine nucleotide biosynthetic process |
A | 0019674 | biological_process | NAD+ metabolic process |
A | 0019805 | biological_process | quinolinate biosynthetic process |
A | 0043420 | biological_process | anthranilate metabolic process |
A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
A | 0070189 | biological_process | kynurenine metabolic process |
A | 0071949 | molecular_function | FAD binding |
B | 0003824 | molecular_function | catalytic activity |
B | 0004497 | molecular_function | monooxygenase activity |
B | 0004502 | molecular_function | kynurenine 3-monooxygenase activity |
B | 0006569 | biological_process | L-tryptophan catabolic process |
B | 0009435 | biological_process | NAD+ biosynthetic process |
B | 0016174 | molecular_function | NAD(P)H oxidase H2O2-forming activity |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0019363 | biological_process | pyridine nucleotide biosynthetic process |
B | 0019674 | biological_process | NAD+ metabolic process |
B | 0019805 | biological_process | quinolinate biosynthetic process |
B | 0043420 | biological_process | anthranilate metabolic process |
B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
B | 0070189 | biological_process | kynurenine metabolic process |
B | 0071949 | molecular_function | FAD binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 36 |
Details | binding site for residue FAD A 501 |
Chain | Residue |
A | ILE12 |
A | ALA55 |
A | ARG110 |
A | GLY133 |
A | LEU134 |
A | ALA164 |
A | ASP165 |
A | GLY166 |
A | ALA170 |
A | TYR192 |
A | GLY309 |
A | GLY13 |
A | ASP310 |
A | GLY320 |
A | GLN321 |
A | GLY322 |
A | MET323 |
A | ASN324 |
A | E0T502 |
A | HOH675 |
A | HOH678 |
A | HOH687 |
A | GLY15 |
A | HOH732 |
A | HOH737 |
A | HOH744 |
A | HOH789 |
A | HOH798 |
A | HOH804 |
A | HOH847 |
A | LEU16 |
A | ALA17 |
A | GLU36 |
A | ARG37 |
A | ARG38 |
A | LEU54 |
site_id | AC2 |
Number of Residues | 13 |
Details | binding site for residue E0T A 502 |
Chain | Residue |
A | ARG83 |
A | TYR97 |
A | ILE105 |
A | LEU212 |
A | ILE223 |
A | PHE237 |
A | PRO317 |
A | GLY320 |
A | MET372 |
A | TYR403 |
A | FAD501 |
A | HOH695 |
A | HOH696 |
site_id | AC3 |
Number of Residues | 3 |
Details | binding site for residue PGE A 503 |
Chain | Residue |
A | ASN33 |
A | HIS129 |
A | LYS156 |
site_id | AC4 |
Number of Residues | 5 |
Details | binding site for residue CA A 504 |
Chain | Residue |
A | SER147 |
A | ASN148 |
A | HOH621 |
A | HOH781 |
A | HOH879 |
site_id | AC5 |
Number of Residues | 36 |
Details | binding site for residue FAD B 501 |
Chain | Residue |
B | ILE12 |
B | GLY13 |
B | ALA14 |
B | GLY15 |
B | LEU16 |
B | ALA17 |
B | GLU36 |
B | ARG37 |
B | ARG38 |
B | LEU54 |
B | ALA55 |
B | ARG110 |
B | GLY133 |
B | LEU134 |
B | ALA164 |
B | ASP165 |
B | GLY166 |
B | ALA170 |
B | GLY309 |
B | ASP310 |
B | GLY320 |
B | GLN321 |
B | GLY322 |
B | MET323 |
B | ASN324 |
B | E0T502 |
B | HOH601 |
B | HOH681 |
B | HOH687 |
B | HOH691 |
B | HOH722 |
B | HOH738 |
B | HOH741 |
B | HOH802 |
B | HOH805 |
B | HOH865 |
site_id | AC6 |
Number of Residues | 12 |
Details | binding site for residue E0T B 502 |
Chain | Residue |
B | PRO317 |
B | GLY320 |
B | MET372 |
B | TYR403 |
B | FAD501 |
B | HOH685 |
B | ARG83 |
B | TYR97 |
B | ILE105 |
B | LEU212 |
B | ILE223 |
B | PHE237 |
site_id | AC7 |
Number of Residues | 3 |
Details | binding site for residue PGE B 503 |
Chain | Residue |
B | PHE35 |
B | LEU154 |
B | LYS156 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 16 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"28336141","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28398044","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28604669","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29208702","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29429898","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5FN0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MZC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MZI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MZK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5N7T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5NA5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5NAB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5NAE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5NAG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5NAH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5NAK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5X6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5X6Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5Y66","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5Y77","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5Y7A","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"29208702","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5Y66","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5Y77","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"29208702","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5Y77","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | Binding site: {"evidences":[{"source":"PubMed","id":"29208702","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5Y66","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5Y77","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5Y7A","evidenceCode":"ECO:0007744"}]} |
Chain | Residue | Details |