6FOX
The crystal structure of P.fluorescens Kynurenine 3-monooxygenase (KMO) in complex with kynurenine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0004502 | molecular_function | kynurenine 3-monooxygenase activity |
| A | 0006569 | biological_process | L-tryptophan catabolic process |
| A | 0009435 | biological_process | NAD+ biosynthetic process |
| A | 0016174 | molecular_function | NAD(P)H oxidase H2O2-forming activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0019363 | biological_process | pyridine nucleotide biosynthetic process |
| A | 0019674 | biological_process | NAD+ metabolic process |
| A | 0019805 | biological_process | quinolinate biosynthetic process |
| A | 0043420 | biological_process | anthranilate metabolic process |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0070189 | biological_process | kynurenine metabolic process |
| A | 0071949 | molecular_function | FAD binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004497 | molecular_function | monooxygenase activity |
| B | 0004502 | molecular_function | kynurenine 3-monooxygenase activity |
| B | 0006569 | biological_process | L-tryptophan catabolic process |
| B | 0009435 | biological_process | NAD+ biosynthetic process |
| B | 0016174 | molecular_function | NAD(P)H oxidase H2O2-forming activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0019363 | biological_process | pyridine nucleotide biosynthetic process |
| B | 0019674 | biological_process | NAD+ metabolic process |
| B | 0019805 | biological_process | quinolinate biosynthetic process |
| B | 0043420 | biological_process | anthranilate metabolic process |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0070189 | biological_process | kynurenine metabolic process |
| B | 0071949 | molecular_function | FAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 36 |
| Details | binding site for residue FAD A 501 |
| Chain | Residue |
| A | ILE13 |
| A | ALA56 |
| A | ARG111 |
| A | GLY134 |
| A | LEU135 |
| A | ALA165 |
| A | ASP166 |
| A | GLY167 |
| A | ALA171 |
| A | TYR193 |
| A | GLY310 |
| A | GLY14 |
| A | ASP311 |
| A | PRO318 |
| A | GLY321 |
| A | GLN322 |
| A | GLY323 |
| A | MET324 |
| A | ASN325 |
| A | CA502 |
| A | HOH647 |
| A | HOH660 |
| A | GLY16 |
| A | HOH699 |
| A | HOH718 |
| A | HOH724 |
| A | HOH776 |
| A | HOH794 |
| A | HOH856 |
| A | HOH916 |
| A | LEU17 |
| A | ALA18 |
| A | GLU37 |
| A | ARG38 |
| A | ARG39 |
| A | LEU55 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 502 |
| Chain | Residue |
| A | PRO318 |
| A | GLN322 |
| A | GLY323 |
| A | FAD501 |
| A | HOH881 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | binding site for residue KYN B 501 |
| Chain | Residue |
| B | ALA56 |
| B | ARG84 |
| B | TYR98 |
| B | ILE224 |
| B | PRO318 |
| B | PHE319 |
| B | HIS320 |
| B | GLY321 |
| B | ASN369 |
| B | TYR404 |
| B | FAD502 |
| site_id | AC4 |
| Number of Residues | 33 |
| Details | binding site for residue FAD B 502 |
| Chain | Residue |
| B | ILE13 |
| B | GLY14 |
| B | GLY16 |
| B | LEU17 |
| B | ALA18 |
| B | GLU37 |
| B | ARG38 |
| B | ARG39 |
| B | LEU55 |
| B | ALA56 |
| B | ARG111 |
| B | GLY134 |
| B | LEU135 |
| B | ALA165 |
| B | ASP166 |
| B | ALA171 |
| B | GLU195 |
| B | GLY310 |
| B | ASP311 |
| B | GLY321 |
| B | GLN322 |
| B | GLY323 |
| B | MET324 |
| B | ASN325 |
| B | KYN501 |
| B | HOH616 |
| B | HOH641 |
| B | HOH673 |
| B | HOH677 |
| B | HOH680 |
| B | HOH729 |
| B | HOH738 |
| B | HOH774 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 16 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28336141","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28398044","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28604669","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29208702","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29429898","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5FN0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MZC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MZI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5MZK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5N7T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5NA5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5NAB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5NAE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5NAG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5NAH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5NAK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5X6P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5X6Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5Y66","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5Y77","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5Y7A","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29208702","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5Y66","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5Y77","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29208702","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5Y77","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"29208702","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5Y66","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5Y77","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5Y7A","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
