6FNK

Crystal Structure of Ephrin B4 (EphB4) Receptor Protein Kinase with a pyrazolo[3,4-d]pyrimidine fragment of NVP-BHG712

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue DXK A 1001

Chain	Residue
A	ALA623
A	HOH1265
A	HOH1290
A	GLY624
A	ALA645
A	ILE677
A	THR693
A	GLU694
A	MET696
A	LEU747
A	HOH1224

---

site_id	AC2
Number of Residues	7
Details	binding site for residue EDO A 1002

Chain	Residue
A	ASP855
A	GLN858
A	ALA863
A	PRO865
A	GLN869
A	HOH1219
A	HOH1230

---

site_id	AC3
Number of Residues	7
Details	binding site for residue EDO A 1003

Chain	Residue
A	ARG729
A	PRO868
A	HOH1109
A	HOH1117
A	HOH1133
A	HOH1165
A	HOH1269

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	27
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGAGEFGEVCrGrlkapgkkesc.......VAIK

Chain	Residue	Details
A	ILE621-LYS647

---

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. YVHrDLAARNILV

Chain	Residue	Details
A	TYR736-VAL748

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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