Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008134 | molecular_function | transcription factor binding |
| A | 0016567 | biological_process | protein ubiquitination |
| A | 0031463 | cellular_component | Cul3-RING ubiquitin ligase complex |
| B | 0008134 | molecular_function | transcription factor binding |
| B | 0016567 | biological_process | protein ubiquitination |
| B | 0031463 | cellular_component | Cul3-RING ubiquitin ligase complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 701 |
| Chain | Residue |
| A | ARG380 |
| A | THR388 |
| A | ASP389 |
| A | GLY433 |
| A | HOH817 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 702 |
| Chain | Residue |
| A | ALA356 |
| A | ASP357 |
| A | ARG470 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue ACT A 703 |
| Chain | Residue |
| A | HIS437 |
| A | HIS432 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue ACT A 704 |
| Chain | Residue |
| A | LEU471 |
| A | TYR491 |
| A | PRO492 |
| A | GLU493 |
| A | ARG494 |
| A | HOH842 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 705 |
| Chain | Residue |
| A | TYR334 |
| A | ARG415 |
| A | SER602 |
| A | HOH803 |
| A | HOH854 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue ACT A 706 |
| Chain | Residue |
| A | ARG415 |
| A | PHE478 |
| A | ARG483 |
| A | SER508 |
| A | HOH805 |
| B | ASP385 |
| B | GLY386 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue ACT A 707 |
| Chain | Residue |
| A | GLN337 |
| A | ASN382 |
| A | SER383 |
| A | HOH809 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue NA A 708 |
| Chain | Residue |
| A | ARG415 |
| A | SER508 |
| B | ASP385 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 709 |
| Chain | Residue |
| A | SER390 |
| A | SER391 |
| A | HOH919 |
| A | HOH958 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 710 |
| Chain | Residue |
| A | MET399 |
| A | TYR491 |
| A | HOH811 |
| A | HOH831 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 701 |
| Chain | Residue |
| A | PHE478 |
| A | GLY480 |
| B | ASN387 |
| B | THR388 |
| B | ASP389 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 702 |
| Chain | Residue |
| B | GLY364 |
| B | ARG415 |
| B | GLY509 |
| B | ALA556 |
| B | HOH808 |
| B | HOH852 |
| B | HOH903 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue ACT B 703 |
| Chain | Residue |
| B | LEU355 |
| B | TYR491 |
| B | PRO492 |
| B | GLU493 |
| B | ARG494 |
| B | HOH822 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue ACT B 704 |
| Chain | Residue |
| B | LEU355 |
| B | ASP357 |
| B | ARG470 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue NA B 705 |
| Chain | Residue |
| B | TYR334 |
| B | ARG336 |
| B | ASN382 |
| B | HOH889 |
| B | HOH957 |
| site_id | AD7 |
| Number of Residues | 2 |
| Details | binding site for residue NA B 706 |
| Chain | Residue |
| B | HIS432 |
| B | HOH943 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue NA B 707 |
| Chain | Residue |
| B | HIS436 |
| B | HOH905 |
| B | HOH952 |
| site_id | AD9 |
| Number of Residues | 1 |
| Details | binding site for residue NA B 708 |
| site_id | AE1 |
| Number of Residues | 11 |
| Details | binding site for residues ACE D 1 and DYW D 2 |
| Chain | Residue |
| A | GLY386 |
| A | ASN387 |
| B | TYR525 |
| B | GLN530 |
| B | SER555 |
| B | TYR572 |
| D | GLU3 |
| D | THR4 |
| D | GLY5 |
| D | GLU6 |
| D | HOH103 |
| site_id | AE2 |
| Number of Residues | 15 |
| Details | binding site for Di-peptide DYW D 2 and GLU D 3 |
| Chain | Residue |
| D | GLU6 |
| D | HOH103 |
| A | GLY386 |
| A | ASN387 |
| B | ARG415 |
| B | ARG483 |
| B | SER508 |
| B | TYR525 |
| B | GLN530 |
| B | SER555 |
| B | ALA556 |
| B | TYR572 |
| D | ACE1 |
| D | THR4 |
| D | GLY5 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 90 |
| Details | Repeat: {"description":"Kelch 1"} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 100 |
| Details | Repeat: {"description":"Kelch 2"} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 92 |
| Details | Repeat: {"description":"Kelch 3"} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 92 |
| Details | Repeat: {"description":"Kelch 4"} |
| site_id | SWS_FT_FI5 |
| Number of Residues | 92 |
| Details | Repeat: {"description":"Kelch 5"} |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Site: {"description":"Sensor for electrophilic agents","evidences":[{"source":"UniProtKB","id":"Q9Z2X8","evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"S-cGMP-cysteine","evidences":[{"source":"UniProtKB","id":"Q9Z2X8","evidenceCode":"ECO:0000250"}]} |
