6FL4
A. thaliana NUDT1 in complex with 8-oxo-dGTP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000210 | molecular_function | NAD+ diphosphatase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006974 | biological_process | DNA damage response |
| A | 0008413 | molecular_function | 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019177 | molecular_function | dihydroneopterin triphosphate pyrophosphohydrolase activity |
| A | 0035529 | molecular_function | NADH pyrophosphatase activity |
| A | 0035539 | molecular_function | 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000210 | molecular_function | NAD+ diphosphatase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006974 | biological_process | DNA damage response |
| B | 0008413 | molecular_function | 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0019177 | molecular_function | dihydroneopterin triphosphate pyrophosphohydrolase activity |
| B | 0035529 | molecular_function | NADH pyrophosphatase activity |
| B | 0035539 | molecular_function | 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 201 |
| Chain | Residue |
| A | GLY40 |
| A | GLU60 |
| A | MG202 |
| A | 8DG203 |
| A | HOH333 |
| A | HOH387 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 202 |
| Chain | Residue |
| A | 8DG203 |
| A | HOH304 |
| A | HOH305 |
| A | GLU56 |
| A | GLU60 |
| A | MG201 |
| site_id | AC3 |
| Number of Residues | 24 |
| Details | binding site for residue 8DG A 203 |
| Chain | Residue |
| A | ALA11 |
| A | VAL13 |
| A | ARG27 |
| A | LEU38 |
| A | GLY40 |
| A | GLY41 |
| A | HIS42 |
| A | GLU56 |
| A | GLU60 |
| A | ASN76 |
| A | PHE78 |
| A | SER89 |
| A | LYS110 |
| A | PHE127 |
| A | MG201 |
| A | MG202 |
| A | HOH304 |
| A | HOH327 |
| A | HOH333 |
| A | HOH351 |
| A | HOH357 |
| A | HOH360 |
| A | HOH387 |
| B | GLU120 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 201 |
| Chain | Residue |
| B | GLU56 |
| B | GLU60 |
| B | MG202 |
| B | 8DG203 |
| B | HOH322 |
| B | HOH325 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 202 |
| Chain | Residue |
| B | GLY40 |
| B | GLU60 |
| B | MG201 |
| B | 8DG203 |
| B | HOH357 |
| B | HOH376 |
| site_id | AC6 |
| Number of Residues | 24 |
| Details | binding site for residue 8DG B 203 |
| Chain | Residue |
| B | ALA11 |
| B | VAL13 |
| B | ARG27 |
| B | ALA37 |
| B | LEU38 |
| B | GLY40 |
| B | GLY41 |
| B | HIS42 |
| B | GLU56 |
| B | GLU60 |
| B | ASN76 |
| B | SER89 |
| B | LYS110 |
| B | PHE127 |
| B | PRO129 |
| B | MG201 |
| B | MG202 |
| B | HOH301 |
| B | HOH314 |
| B | HOH325 |
| B | HOH350 |
| B | HOH357 |
| B | HOH376 |
| B | HOH392 |
Functional Information from PROSITE/UniProt
| site_id | PS00893 |
| Number of Residues | 22 |
| Details | NUDIX_BOX Nudix box signature. GhlefgEsfeeCAaREVmEEtG |
| Chain | Residue | Details |
| A | GLY41-GLY62 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | GLU56 | |
| A | GLU60 | |
| B | GLU56 | |
| B | GLU60 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: N-acetylserine => ECO:0007744|PubMed:22223895 |
| Chain | Residue | Details |
| A | SER2 | |
| B | SER2 |
