6FK1
Cyclophilin A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000413 | biological_process | protein peptidyl-prolyl isomerization |
| A | 0001933 | biological_process | negative regulation of protein phosphorylation |
| A | 0001934 | biological_process | positive regulation of protein phosphorylation |
| A | 0003755 | molecular_function | peptidyl-prolyl cis-trans isomerase activity |
| A | 0005178 | molecular_function | integrin binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006457 | biological_process | protein folding |
| A | 0006469 | biological_process | negative regulation of protein kinase activity |
| A | 0006915 | biological_process | apoptotic process |
| A | 0016018 | molecular_function | cyclosporin A binding |
| A | 0030168 | biological_process | platelet activation |
| A | 0030182 | biological_process | neuron differentiation |
| A | 0030593 | biological_process | neutrophil chemotaxis |
| A | 0030595 | biological_process | leukocyte chemotaxis |
| A | 0032148 | biological_process | activation of protein kinase B activity |
| A | 0032873 | biological_process | negative regulation of stress-activated MAPK cascade |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0034389 | biological_process | lipid droplet organization |
| A | 0034599 | biological_process | cellular response to oxidative stress |
| A | 0035307 | biological_process | positive regulation of protein dephosphorylation |
| A | 0042118 | biological_process | endothelial cell activation |
| A | 0043209 | cellular_component | myelin sheath |
| A | 0043410 | biological_process | positive regulation of MAPK cascade |
| A | 0045069 | biological_process | regulation of viral genome replication |
| A | 0045070 | biological_process | positive regulation of viral genome replication |
| A | 0050714 | biological_process | positive regulation of protein secretion |
| A | 0051092 | biological_process | positive regulation of NF-kappaB transcription factor activity |
| A | 0060352 | biological_process | cell adhesion molecule production |
| A | 0061944 | biological_process | negative regulation of protein K48-linked ubiquitination |
| A | 0070527 | biological_process | platelet aggregation |
| A | 1902176 | biological_process | negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
| A | 1903901 | biological_process | negative regulation of viral life cycle |
| A | 1904399 | molecular_function | heparan sulfate binding |
| A | 2001233 | biological_process | regulation of apoptotic signaling pathway |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 201 |
| Chain | Residue |
| A | PRO95 |
| A | GLY96 |
| A | LYS131 |
| A | VAL132 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue EDO A 202 |
| Chain | Residue |
| A | HIS126 |
| A | GLN163 |
| A | HOH304 |
| A | HOH325 |
| A | HOH339 |
| A | PHE7 |
| A | ARG19 |
| A | ASN102 |
| A | GLY104 |
| A | LYS125 |
Functional Information from PROSITE/UniProt
| site_id | PS00170 |
| Number of Residues | 18 |
| Details | CSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YkgSsFHRIIpgFMcQGG |
| Chain | Residue | Details |
| A | TYR48-GLY65 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylmethionine => ECO:0000250|UniProtKB:P62937 |
| Chain | Residue | Details |
| A | MET1 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylvaline; in Peptidyl-prolyl cis-trans isomerase A, N-terminally processed => ECO:0000250|UniProtKB:P62937 |
| Chain | Residue | Details |
| A | VAL2 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P62937 |
| Chain | Residue | Details |
| A | LYS28 | |
| A | LYS82 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P62937 |
| Chain | Residue | Details |
| A | LYS44 | |
| A | LYS125 | |
| A | LYS131 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P62937 |
| Chain | Residue | Details |
| A | SER77 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:21183079 |
| Chain | Residue | Details |
| A | THR93 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:23806337 |
| Chain | Residue | Details |
| A | LYS133 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN108 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62937 |
| Chain | Residue | Details |
| A | LYS28 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0000250|UniProtKB:P62937 |
| Chain | Residue | Details |
| A | LYS82 |
