Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6FJ5

New Insights into the Role of DNA Shape on Its Recognition by p53 Proteins (complex p53DBD-AGG-HG)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000976	molecular_function	transcription cis-regulatory region binding
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription
A	0006915	biological_process	apoptotic process
B	0000976	molecular_function	transcription cis-regulatory region binding
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0005634	cellular_component	nucleus
B	0006355	biological_process	regulation of DNA-templated transcription
B	0006915	biological_process	apoptotic process
C	0000976	molecular_function	transcription cis-regulatory region binding
C	0003677	molecular_function	DNA binding
C	0003700	molecular_function	DNA-binding transcription factor activity
C	0005634	cellular_component	nucleus
C	0006355	biological_process	regulation of DNA-templated transcription
C	0006915	biological_process	apoptotic process
D	0000976	molecular_function	transcription cis-regulatory region binding
D	0003677	molecular_function	DNA binding
D	0003700	molecular_function	DNA-binding transcription factor activity
D	0005634	cellular_component	nucleus
D	0006355	biological_process	regulation of DNA-templated transcription
D	0006915	biological_process	apoptotic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 301

Chain	Residue
A	CYS176
A	HIS179
A	CYS238
A	CYS242

site_id	AC2
Number of Residues	6
Details	binding site for residue EDO A 302

Chain	Residue
B	VAL97
A	THR231
A	HIS233
A	HOH403
A	HOH435
A	HOH522

site_id	AC3
Number of Residues	6
Details	binding site for residue EDO A 303

Chain	Residue
A	LYS132
A	SER240
A	PRO250
A	VAL272
A	ARG273
A	HOH446

site_id	AC4
Number of Residues	7
Details	binding site for residue EDO A 304

Chain	Residue
A	SER95
A	VAL97
A	HOH401
A	HOH404
B	THR231
B	HIS233
B	EDO304

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN B 301

Chain	Residue
B	CYS176
B	HIS179
B	CYS238
B	CYS242

site_id	AC6
Number of Residues	7
Details	binding site for residue EDO B 302

Chain	Residue
B	LYS132
B	SER240
B	PRO250
B	VAL272
B	ARG273
B	HOH404
B	HOH455

site_id	AC7
Number of Residues	4
Details	binding site for residue EDO B 303

Chain	Residue
B	LEU114
B	CYS124
B	PRO142
B	HOH506

site_id	AC8
Number of Residues	10
Details	binding site for residue EDO B 304

Chain	Residue
A	SER95
A	VAL97
A	EDO304
B	VAL197
B	GLU198
B	GLY199
B	THR231
B	ILE232
B	HIS233
B	HOH431

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN C 301

Chain	Residue
C	CYS176
C	HIS179
C	CYS238
C	CYS242

site_id	AD1
Number of Residues	4
Details	binding site for residue EDO C 302

Chain	Residue
C	ARG110
C	LEU111
C	TRP146
C	HOH476

site_id	AD2
Number of Residues	6
Details	binding site for residue EDO C 303

Chain	Residue
C	PHE113
C	LEU114
C	CYS124
C	THR125
C	TYR126
C	PRO142

site_id	AD3
Number of Residues	7
Details	binding site for residue EDO C 304

Chain	Residue
C	LYS132
C	SER240
C	PRO250
C	VAL272
C	ARG273
C	GLU285
C	HOH492

site_id	AD4
Number of Residues	3
Details	binding site for residue EDO C 305

Chain	Residue
C	PRO98
C	SER99
C	GLN100

site_id	AD5
Number of Residues	4
Details	binding site for residue ZN D 301

Chain	Residue
D	CYS176
D	HIS179
D	CYS238
D	CYS242

site_id	AD6
Number of Residues	4
Details	binding site for residue EDO D 302

Chain	Residue
D	ARG110
D	LEU111
D	TRP146
D	HOH496

site_id	AD7
Number of Residues	6
Details	binding site for residue EDO D 303

Chain	Residue
D	PHE113
D	LEU114
D	CYS124
D	THR125
D	TYR126
D	PRO142

site_id	AD8
Number of Residues	7
Details	binding site for residue EDO D 304

Chain	Residue
D	LYS132
D	SER240
D	PRO250
D	VAL272
D	ARG273
D	GLU285
D	HOH485

site_id	AD9
Number of Residues	4
Details	binding site for residue EDO D 305

Chain	Residue
D	PRO98
D	SER99
D	GLN100
D	ILE162

Functional Information from PROSITE/UniProt

site_id	PS00348
Number of Residues	13
Details	P53 p53 family signature. MCNSSCMGGMNRR

Chain	Residue	Details
A	MET237-ARG249

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	760
Details	DNA binding: {"evidences":[{"source":"PubMed","id":"16793544","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18996393","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20364130","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	492
Details	Region: {"description":"Required for interaction with FBXO42","evidences":[{"source":"PubMed","id":"19509332","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	704
Details	Region: {"description":"Interaction with AXIN1","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	28
Details	Region: {"description":"Interaction with the 53BP2 SH3 domain"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	28
Details	Region: {"description":"Interaction with DNA"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14534297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16793544","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17015838","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18650397","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19515728","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20142040","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20364130","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Site: {"description":"Interaction with DNA","evidences":[{"source":"PubMed","id":"16793544","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18996393","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20364130","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	8
Details	Modified residue: {"description":"N6-lactoyllysine","evidences":[{"source":"PubMed","id":"38653238","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine; by AURKB","evidences":[{"source":"PubMed","id":"20959462","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine; by AURKB","evidences":[{"source":"PubMed","id":"20959462","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	12
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"19536131","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)