6FIU

Human cytosolic 5'-nucleotidase II soaked with 10mM 2-(6-([1,1'-Biphenyl]-3-carboxamido)-9H-purin-9-yl)acetic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000255	biological_process	allantoin metabolic process
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006204	biological_process	IMP catabolic process
A	0008253	molecular_function	5'-nucleotidase activity
A	0009117	biological_process	nucleotide metabolic process
A	0016740	molecular_function	transferase activity
A	0016787	molecular_function	hydrolase activity
A	0042802	molecular_function	identical protein binding
A	0046037	biological_process	GMP metabolic process
A	0046040	biological_process	IMP metabolic process
A	0046054	biological_process	dGMP metabolic process
A	0046085	biological_process	adenosine metabolic process
A	0046872	molecular_function	metal ion binding
A	0050146	molecular_function	nucleoside phosphotransferase activity
A	0050483	molecular_function	IMP 5'-nucleotidase activity
A	0050484	molecular_function	GMP 5'-nucleotidase activity
A	0050689	biological_process	negative regulation of defense response to virus by host
A	0061630	molecular_function	ubiquitin protein ligase activity
A	0070936	biological_process	protein K48-linked ubiquitination
A	0106411	molecular_function	XMP 5'-nucleosidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue SO4 A 601

Chain	Residue
A	ASN250
A	HOH715
A	HOH723
A	HOH744
A	HOH753

---

site_id	AC2
Number of Residues	2
Details	binding site for residue SO4 A 602

Chain	Residue
A	ASP187
A	GLY188

---

site_id	AC3
Number of Residues	4
Details	binding site for residue SO4 A 603

Chain	Residue
A	ARG29
A	TYR475
A	LYS25
A	ARG28

---

site_id	AC4
Number of Residues	5
Details	binding site for residue SO4 A 604

Chain	Residue
A	GLY130
A	PRO131
A	ARG134
A	LYS140
A	SO4607

---

site_id	AC5
Number of Residues	5
Details	binding site for residue SO4 A 605

Chain	Residue
A	ARG144
A	GLN453
A	ARG456
A	ARG456
A	TYR457

---

site_id	AC6
Number of Residues	3
Details	binding site for residue SO4 A 606

Chain	Residue
A	ASN117
A	LYS344
A	ARG446

---

site_id	AC7
Number of Residues	6
Details	binding site for residue SO4 A 607

Chain	Residue
A	ARG129
A	GLY130
A	PRO131
A	LYS140
A	LYS424
A	SO4604

---

site_id	AC8
Number of Residues	3
Details	binding site for residue GOL A 608

Chain	Residue
A	ARG76
A	TRP207
A	LYS211

---

site_id	AC9
Number of Residues	5
Details	binding site for residue GOL A 609

Chain	Residue
A	PRO96
A	GLU378
A	TYR434
A	LEU440
A	HOH741

---

site_id	AD1
Number of Residues	5
Details	binding site for residue GOL A 610

Chain	Residue
A	ASP257
A	THR261
A	TRP279
A	GLN280
A	HOH704

---

site_id	AD2
Number of Residues	8
Details	binding site for residue GOL A 611

Chain	Residue
A	ARG39
A	ASN117
A	LYS344
A	LYS361
A	ARG367
A	ARG446
A	ASP459
A	HOH835

---

site_id	AD3
Number of Residues	7
Details	binding site for residue GOL A 612

Chain	Residue
A	ASP252
A	TYR253
A	VAL288
A	ASP289
A	GLY310
A	LEU312
A	HOH703

---

site_id	AD4
Number of Residues	9
Details	binding site for residue GOL A 613

Chain	Residue
A	PHE283
A	ASP284
A	ILE286
A	LEU321
A	GLN322
A	HIS323
A	GLY324
A	ILE325
A	HOH713

---

site_id	AD5
Number of Residues	6
Details	binding site for residue MG A 614

Chain	Residue
A	ASP52
A	ASP54
A	ASP351
A	HOH723
A	HOH732
A	HOH753

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000305|PubMed:21396942

Chain	Residue	Details
A	ASP52

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000305|PubMed:21396942

Chain	Residue	Details
A	ASP54

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:17405878, ECO:0000269|PubMed:21396942, ECO:0007744|PDB:2J2C, ECO:0007744|PDB:2JC9, ECO:0007744|PDB:2JCM, ECO:0007744|PDB:2XCV, ECO:0007744|PDB:2XCW, ECO:0007744|PDB:2XJB, ECO:0007744|PDB:2XJC, ECO:0007744|PDB:2XJD, ECO:0007744|PDB:2XJE

Chain	Residue	Details
A	ASP52
A	ASP54

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:21396942, ECO:0007744|PDB:2XJB

Chain	Residue	Details
A	ARG144
A	ARG456

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:21396942, ECO:0007744|PDB:2XJC

Chain	Residue	Details
A	ASN154
A	LYS362
A	GLN453
A	TYR457

---

site_id	SWS_FT_FI6
Number of Residues	7
Details	BINDING: BINDING => ECO:0000269|PubMed:21396942, ECO:0007744|PDB:2XCV, ECO:0007744|PDB:2XCW

Chain	Residue	Details
A	ARG202
A	ASP206
A	LYS215
A	THR249
A	ASN250
A	SER251
A	LYS292

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:17405878, ECO:0000269|PubMed:21396942, ECO:0007744|PDB:2J2C, ECO:0007744|PDB:2JC9, ECO:0007744|PDB:2JCM

Chain	Residue	Details
A	ASP351

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:17405878, ECO:0007744|PDB:2JC9

Chain	Residue	Details
A	MET436

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	SER418
A	SER511

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648

Chain	Residue	Details
A	SER502

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q3V1L4

Chain	Residue	Details
A	SER527

---