6FIE
Crystallographic structure of calcium loaded Calbindin-D28K.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0005499 | molecular_function | vitamin D binding |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0007611 | biological_process | learning or memory |
| B | 0007614 | biological_process | short-term memory |
| B | 0007616 | biological_process | long-term memory |
| B | 0007626 | biological_process | locomotory behavior |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0010842 | biological_process | retina layer formation |
| B | 0010996 | biological_process | response to auditory stimulus |
| B | 0030424 | cellular_component | axon |
| B | 0030425 | cellular_component | dendrite |
| B | 0032420 | cellular_component | stereocilium |
| B | 0032437 | cellular_component | cuticular plate |
| B | 0035502 | biological_process | metanephric part of ureteric bud development |
| B | 0043005 | cellular_component | neuron projection |
| B | 0043025 | cellular_component | neuronal cell body |
| B | 0043195 | cellular_component | terminal bouton |
| B | 0044305 | cellular_component | calyx of Held |
| B | 0045202 | cellular_component | synapse |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0048167 | biological_process | regulation of synaptic plasticity |
| B | 0055074 | biological_process | calcium ion homeostasis |
| B | 0060041 | biological_process | retina development in camera-type eye |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0072205 | biological_process | metanephric collecting duct development |
| B | 0072221 | biological_process | metanephric distal convoluted tubule development |
| B | 0072286 | biological_process | metanephric connecting tubule development |
| B | 0090102 | biological_process | cochlea development |
| B | 0098686 | cellular_component | hippocampal mossy fiber to CA3 synapse |
| B | 0098794 | cellular_component | postsynapse |
| B | 0098978 | cellular_component | glutamatergic synapse |
| B | 0098982 | cellular_component | GABA-ergic synapse |
| B | 0099509 | biological_process | regulation of presynaptic cytosolic calcium ion concentration |
| B | 0099523 | cellular_component | presynaptic cytosol |
| B | 0099524 | cellular_component | postsynaptic cytosol |
| B | 0099534 | molecular_function | calcium ion binding involved in regulation of presynaptic cytosolic calcium ion concentration |
| B | 0099566 | biological_process | regulation of postsynaptic cytosolic calcium ion concentration |
| B | 0099567 | molecular_function | calcium ion binding involved in regulation of postsynaptic cytosolic calcium ion concentration |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 301 |
| Chain | Residue |
| B | ASP199 |
| B | ASP201 |
| B | ASN203 |
| B | TYR205 |
| B | GLU210 |
| B | HOH442 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 302 |
| Chain | Residue |
| B | PHE117 |
| B | GLU119 |
| B | GLU122 |
| B | ASP111 |
| B | ASP113 |
| B | SER115 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 303 |
| Chain | Residue |
| B | ASP155 |
| B | ASN157 |
| B | ASP159 |
| B | LYS161 |
| B | GLU166 |
| B | HOH439 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue CA B 304 |
| Chain | Residue |
| B | ASP24 |
| B | ASP26 |
| B | SER28 |
| B | TYR30 |
| B | GLU35 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue SCN B 305 |
| Chain | Residue |
| B | ALA50 |
| B | GLY51 |
| B | ASN203 |
| B | TYR205 |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DADGSGYLEgkEL |
| Chain | Residue | Details |
| B | ASP24-LEU36 | |
| B | ASP111-LEU123 | |
| B | ASP155-MET167 | |
| B | ASP199-LEU211 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 35 |
| Details | Domain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 35 |
| Details | Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 35 |
| Details | Domain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 35 |
| Details | Domain: {"description":"EF-hand 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 5 |
| Details | Region: {"description":"Interaction with RANBP9","evidences":[{"source":"PubMed","id":"12684061","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 19 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"30289411","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6FIE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylalanine","evidences":[{"source":"UniProtKB","id":"P04467","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
