6FH3
Protein arginine kinase McsB in the pArg-bound state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004111 | molecular_function | creatine kinase activity |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005615 | cellular_component | extracellular space |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016772 | molecular_function | transferase activity, transferring phosphorus-containing groups |
| A | 0016775 | molecular_function | phosphotransferase activity, nitrogenous group as acceptor |
| A | 0046314 | biological_process | phosphocreatine biosynthetic process |
| A | 1990424 | molecular_function | protein arginine kinase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004111 | molecular_function | creatine kinase activity |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005615 | cellular_component | extracellular space |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016772 | molecular_function | transferase activity, transferring phosphorus-containing groups |
| B | 0016775 | molecular_function | phosphotransferase activity, nitrogenous group as acceptor |
| B | 0046314 | biological_process | phosphocreatine biosynthetic process |
| B | 1990424 | molecular_function | protein arginine kinase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue RPI A 401 |
| Chain | Residue |
| A | VAL283 |
| A | HOH566 |
| A | HOH590 |
| B | GLN266 |
| B | HOH591 |
| A | ASP285 |
| A | SER286 |
| A | GLU336 |
| A | ARG338 |
| A | ASP339 |
| A | ARG342 |
| A | EDO406 |
| A | HOH531 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 402 |
| Chain | Residue |
| A | ALA279 |
| A | ARG282 |
| A | ARG347 |
| A | ARG351 |
| A | HOH576 |
| A | HOH587 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 403 |
| Chain | Residue |
| A | ALA10 |
| A | VAL11 |
| A | SER12 |
| A | MET15 |
| A | LYS91 |
| A | LEU93 |
| A | GLU113 |
| A | LEU130 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 405 |
| Chain | Residue |
| A | ALA137 |
| A | ALA239 |
| A | HOH512 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 406 |
| Chain | Residue |
| A | GLU336 |
| A | RPI401 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | binding site for residue RPI B 401 |
| Chain | Residue |
| B | ASP285 |
| B | SER286 |
| B | PRO322 |
| B | PRO335 |
| B | ARG338 |
| B | ASP339 |
| B | ARG342 |
| B | HOH507 |
| B | HOH511 |
| B | HOH521 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 402 |
| Chain | Residue |
| B | PHE272 |
| B | TYR275 |
| B | ASN307 |
| B | HOH610 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 403 |
| Chain | Residue |
| B | ARG86 |
| B | GLU213 |
| B | GLN321 |
| B | PRO322 |
| B | GLY323 |
| B | PHE324 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 404 |
| Chain | Residue |
| B | PHE61 |
| B | TRP149 |
Functional Information from PROSITE/UniProt
| site_id | PS00112 |
| Number of Residues | 7 |
| Details | PHOSPHAGEN_KINASE Phosphagen kinase active site signature. CP.TNVGT |
| Chain | Residue | Details |
| A | CYS168-THR174 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 231 |
| Details | Domain: {"description":"Phosphagen kinase C-terminal"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 10 |
| Details | Motif: {"description":"RDXXRA motif of the pArg binding pocket involved in allosteric regulation","evidences":[{"source":"PubMed","id":"30962626","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"30962626","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00602","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00602","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"30962626","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
