6FEX

DDR1, 2-[4-bromo-2-oxo-1'-(1H-pyrazolo[4,3-b]pyridine-5-carbonyl)spiro[indole-3,4'-piperidine]-1-yl]-N-(2,2,2-trifluoroethyl)acetamide, 1.291A, P212121, Rfree=17.4%

Replaces:  6FIM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0004714	molecular_function	transmembrane receptor protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
A	0007169	biological_process	cell surface receptor protein tyrosine kinase signaling pathway
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue D6Z A 1001

Chain	Residue
A	VAL624
A	LEU773
A	ALA783
A	ASP784
A	PHE785
A	HOH1214
A	HOH1274
A	HOH1323
A	ALA653
A	GLU672
A	MET676
A	ILE685
A	THR701
A	TYR703
A	MET704
A	HIS764

---

site_id	AC2
Number of Residues	1
Details	binding site for residue IOD A 1002

Chain	Residue
A	ARG886

---

site_id	AC3
Number of Residues	1
Details	binding site for residue IOD A 1003

Chain	Residue
A	HOH1361

---

site_id	AC4
Number of Residues	1
Details	binding site for residue IOD A 1004

Chain	Residue
A	ARG658

---

site_id	AC5
Number of Residues	1
Details	binding site for residue IOD A 1005

Chain	Residue
A	MES1006

---

site_id	AC6
Number of Residues	10
Details	binding site for residue MES A 1006

Chain	Residue
A	TRP834
A	MET838
A	ALA842
A	GLN843
A	PHE845
A	GLY846
A	LEU870
A	SER871
A	IOD1005
A	HOH1113

---

site_id	AC7
Number of Residues	1
Details	binding site for residue CL A 1007

Chain	Residue
A	SER739

---

site_id	AC8
Number of Residues	4
Details	binding site for residue CL A 1008

Chain	Residue
A	ASP681
A	PRO682
A	ARG686
A	HOH1188

---

site_id	AC9
Number of Residues	1
Details	binding site for residue CL A 1009

Chain	Residue
A	CYS698

---

site_id	AD1
Number of Residues	3
Details	binding site for residue CL A 1010

Chain	Residue
A	GLN717
A	LEU718
A	HOH1378

---

Functional Information from PROSITE/UniProt

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDLATRNCLV

Chain	Residue	Details
A	PHE762-VAL774

---

site_id	PS00239
Number of Residues	9
Details	RECEPTOR_TYR_KIN_II Receptor tyrosine kinase class II signature. NLYagdYYR

Chain	Residue	Details
A	ASN790-ARG798

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028

Chain	Residue	Details
A	LEU791

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	LEU635

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING:

Chain	Residue	Details
A	LYS674

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195

Chain	Residue	Details
A	LEU650

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000305|PubMed:16337946

Chain	Residue	Details
A	ARG765

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:24509848

Chain	Residue	Details
A	MET817
A	THR821
A	THR822

---