6FET
Crystal structure of human phosphodiesterase 4D2 catalytic domain with inhibitor NPD-1439
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| C | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| C | 0007165 | biological_process | signal transduction |
| C | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| D | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| D | 0007165 | biological_process | signal transduction |
| D | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue ZN A 501 |
| Chain | Residue |
| A | HIS164 |
| A | HIS200 |
| A | ASP201 |
| A | ASP318 |
| A | HOH618 |
| A | HOH674 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 502 |
| Chain | Residue |
| A | HOH644 |
| A | HOH704 |
| A | HOH725 |
| A | ASP201 |
| A | HOH618 |
| A | HOH624 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 503 |
| Chain | Residue |
| A | SER208 |
| A | PHE340 |
| A | PRO356 |
| A | CYS358 |
| A | HOH634 |
| A | HOH726 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 504 |
| Chain | Residue |
| A | HIS152 |
| A | GLU243 |
| A | HOH740 |
| C | SER217 |
| C | ARG350 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 505 |
| Chain | Residue |
| A | GLU218 |
| A | HOH630 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 506 |
| Chain | Residue |
| A | GLN210 |
| A | ILE213 |
| A | HOH615 |
| A | HOH690 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 507 |
| Chain | Residue |
| A | GLU244 |
| A | ASN245 |
| A | HOH633 |
| D | ARG257 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 508 |
| Chain | Residue |
| A | THR134 |
| A | LYS136 |
| D | ASP391 |
| D | EDO506 |
| D | PEG519 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 509 |
| Chain | Residue |
| A | SER259 |
| A | TYR303 |
| A | EDO521 |
| A | HOH758 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue PEG A 510 |
| Chain | Residue |
| A | ASP266 |
| A | LEU269 |
| A | LYS275 |
| A | ASN278 |
| A | ASP282 |
| A | GLN311 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 511 |
| Chain | Residue |
| A | LEU175 |
| A | THR178 |
| A | TRP384 |
| A | ASP391 |
| A | ILE395 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 512 |
| Chain | Residue |
| A | ASN115 |
| A | ALA155 |
| A | ASN161 |
| A | ASN162 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 513 |
| Chain | Residue |
| A | LYS262 |
| A | ILE265 |
| A | ASP266 |
| B | HOH647 |
| B | HOH664 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 514 |
| Chain | Residue |
| A | PHE238 |
| A | PHE249 |
| A | ARG257 |
| A | HOH621 |
| A | HOH648 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 515 |
| Chain | Residue |
| A | SER226 |
| A | ASN231 |
| B | SER226 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 516 |
| Chain | Residue |
| A | ASN115 |
| A | ARG116 |
| A | GLU150 |
| A | ASP151 |
| A | TYR153 |
| site_id | AD8 |
| Number of Residues | 17 |
| Details | binding site for residue D68 A 517 |
| Chain | Residue |
| A | MET273 |
| A | LEU319 |
| A | ASN321 |
| A | PRO322 |
| A | TYR329 |
| A | TRP332 |
| A | THR333 |
| A | ILE336 |
| A | PHE340 |
| A | PRO356 |
| A | MET357 |
| A | SER368 |
| A | GLN369 |
| A | GLY371 |
| A | PHE372 |
| A | ILE376 |
| A | HOH710 |
| site_id | AD9 |
| Number of Residues | 8 |
| Details | binding site for residue EPE A 518 |
| Chain | Residue |
| A | GLN331 |
| A | HIS105 |
| A | VAL106 |
| A | PHE107 |
| A | ARG108 |
| A | GLU111 |
| A | GLN327 |
| A | LEU328 |
| site_id | AE1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 519 |
| Chain | Residue |
| A | THR119 |
| A | HIS123 |
| A | EDO520 |
| site_id | AE2 |
| Number of Residues | 2 |
| Details | binding site for residue EDO A 520 |
| Chain | Residue |
| A | SER113 |
| A | EDO519 |
| site_id | AE3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 521 |
| Chain | Residue |
| A | THR186 |
| A | GLU189 |
| A | SER259 |
| A | EDO509 |
| A | HOH628 |
| D | EDO516 |
| site_id | AE4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 522 |
| Chain | Residue |
| A | ASP140 |
| A | THR141 |
| A | ASN245 |
| site_id | AE5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 523 |
| Chain | Residue |
| A | ASP187 |
| A | HOH730 |
| D | LYS101 |
| D | HOH731 |
| site_id | AE6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 524 |
| Chain | Residue |
| A | LEU176 |
| A | LEU181 |
| A | ALA183 |
| A | VAL184 |
| A | PHE185 |
| A | ILE190 |
| site_id | AE7 |
| Number of Residues | 5 |
| Details | binding site for residue NI A 525 |
| Chain | Residue |
| A | HIS154 |
| A | ASP156 |
| A | HOH744 |
| C | HIS154 |
| C | HOH604 |
| site_id | AE8 |
| Number of Residues | 6 |
| Details | binding site for residue ZN B 501 |
| Chain | Residue |
| B | HIS164 |
| B | HIS200 |
| B | ASP201 |
| B | ASP318 |
| B | HOH613 |
| B | HOH698 |
| site_id | AE9 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 502 |
| Chain | Residue |
| B | ASP201 |
| B | HOH613 |
| B | HOH631 |
| B | HOH648 |
| B | HOH652 |
| B | HOH709 |
| site_id | AF1 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 503 |
| Chain | Residue |
| B | SER208 |
| B | PHE340 |
| B | PRO356 |
| B | CYS358 |
| B | HOH603 |
| B | HOH684 |
| site_id | AF2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 504 |
| Chain | Residue |
| B | PHE107 |
| B | GLN331 |
| B | ASP334 |
| B | ARG335 |
| site_id | AF3 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 505 |
| Chain | Residue |
| B | GLU366 |
| B | TRP405 |
| site_id | AF4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 506 |
| Chain | Residue |
| A | ASN224 |
| A | ASP225 |
| B | LYS262 |
| B | ILE265 |
| B | ASP266 |
| site_id | AF5 |
| Number of Residues | 11 |
| Details | binding site for residue EPE B 507 |
| Chain | Residue |
| B | ASP140 |
| B | THR141 |
| B | ASN245 |
| B | GLN250 |
| B | LYS290 |
| B | VAL292 |
| B | EDO522 |
| B | HOH607 |
| C | THR253 |
| C | LYS254 |
| C | EDO502 |
| site_id | AF6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 508 |
| Chain | Residue |
| B | PRO205 |
| B | ARG346 |
| D | ASP151 |
| D | EDO511 |
| site_id | AF7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 509 |
| Chain | Residue |
| B | THR178 |
| B | ASP391 |
| B | ILE395 |
| site_id | AF8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 510 |
| Chain | Residue |
| B | ASN115 |
| B | ALA155 |
| B | ASN162 |
| B | ILE163 |
| site_id | AF9 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 511 |
| Chain | Residue |
| B | MET286 |
| B | THR289 |
| B | LYS291 |
| B | LEU298 |
| B | LEU299 |
| site_id | AG1 |
| Number of Residues | 4 |
| Details | binding site for residue PEG B 512 |
| Chain | Residue |
| A | HOH718 |
| B | ARG257 |
| B | HOH708 |
| B | HOH715 |
| site_id | AG2 |
| Number of Residues | 8 |
| Details | binding site for residue EPE B 513 |
| Chain | Residue |
| B | HIS105 |
| B | VAL106 |
| B | PHE107 |
| B | ARG108 |
| B | GLU111 |
| B | GLN327 |
| B | LEU328 |
| B | GLN331 |
| site_id | AG3 |
| Number of Residues | 16 |
| Details | binding site for residue D68 B 514 |
| Chain | Residue |
| B | MET273 |
| B | LEU319 |
| B | ASN321 |
| B | PRO322 |
| B | TYR329 |
| B | TRP332 |
| B | THR333 |
| B | ILE336 |
| B | PHE340 |
| B | MET357 |
| B | SER368 |
| B | GLN369 |
| B | GLY371 |
| B | PHE372 |
| B | ILE376 |
| B | HOH674 |
| site_id | AG4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 515 |
| Chain | Residue |
| B | LYS101 |
| B | TRP102 |
| B | EDO518 |
| site_id | AG5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 516 |
| Chain | Residue |
| B | GLU150 |
| B | ASP151 |
| B | TYR153 |
| B | ALA155 |
| B | ASN162 |
| site_id | AG6 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 517 |
| Chain | Residue |
| B | LYS360 |
| B | HIS361 |
| site_id | AG7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 518 |
| Chain | Residue |
| B | ASP98 |
| B | HIS105 |
| B | EDO515 |
| site_id | AG8 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 519 |
| Chain | Residue |
| B | GLU111 |
| B | ARG335 |
| site_id | AG9 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 520 |
| Chain | Residue |
| B | ASN209 |
| B | ASP272 |
| site_id | AH1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 521 |
| Chain | Residue |
| B | HIS152 |
| B | GLU243 |
| B | HOH716 |
| D | THR215 |
| D | SER217 |
| site_id | AH2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 522 |
| Chain | Residue |
| B | ASN245 |
| B | LYS291 |
| B | VAL292 |
| B | LEU299 |
| B | EPE507 |
| C | EDO502 |
| site_id | AH3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 501 |
| Chain | Residue |
| A | GLU218 |
| C | HIS152 |
| C | LYS239 |
| C | HOH602 |
| site_id | AH4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO C 502 |
| Chain | Residue |
| B | GLU244 |
| B | VAL292 |
| B | EPE507 |
| B | EDO522 |
| C | LYS254 |
| site_id | AH5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO C 503 |
| Chain | Residue |
| B | PRO179 |
| C | LYS255 |
| C | SER259 |
| C | HOH616 |
| C | HOH629 |
| site_id | AH6 |
| Number of Residues | 6 |
| Details | binding site for residue ZN C 504 |
| Chain | Residue |
| C | HIS164 |
| C | HIS200 |
| C | ASP201 |
| C | ASP318 |
| C | HOH607 |
| C | HOH676 |
| site_id | AH7 |
| Number of Residues | 6 |
| Details | binding site for residue MG C 505 |
| Chain | Residue |
| C | ASP201 |
| C | HOH607 |
| C | HOH627 |
| C | HOH628 |
| C | HOH668 |
| C | HOH683 |
| site_id | AH8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO C 506 |
| Chain | Residue |
| C | ASN115 |
| C | ARG116 |
| C | GLU150 |
| C | ASP151 |
| C | TYR153 |
| C | ASN162 |
| site_id | AH9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 507 |
| Chain | Residue |
| C | SER208 |
| C | PRO356 |
| C | CYS358 |
| site_id | AI1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 508 |
| Chain | Residue |
| C | PHE238 |
| C | ARG257 |
| C | ARG261 |
| C | HOH606 |
| site_id | AI2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO C 509 |
| Chain | Residue |
| C | PRO138 |
| C | ASP140 |
| C | THR141 |
| C | ASN245 |
| site_id | AI3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO C 510 |
| Chain | Residue |
| C | LEU175 |
| C | THR178 |
| C | TRP384 |
| C | ALA392 |
| C | ILE395 |
| site_id | AI4 |
| Number of Residues | 5 |
| Details | binding site for residue PEG C 511 |
| Chain | Residue |
| A | LEU212 |
| C | ASP151 |
| C | HIS152 |
| C | GLU243 |
| C | HOH678 |
| site_id | AI5 |
| Number of Residues | 9 |
| Details | binding site for residue EPE C 512 |
| Chain | Residue |
| C | HIS105 |
| C | VAL106 |
| C | PHE107 |
| C | ARG108 |
| C | GLU111 |
| C | GLN327 |
| C | LEU328 |
| C | GLN331 |
| C | HOH710 |
| site_id | AI6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO C 513 |
| Chain | Residue |
| C | PRO325 |
| C | LEU326 |
| C | ASP401 |
| C | ASN402 |
| C | HOH617 |
| D | ARG330 |
| site_id | AI7 |
| Number of Residues | 5 |
| Details | binding site for residue PG4 C 514 |
| Chain | Residue |
| C | GLU95 |
| C | ASP98 |
| C | TRP102 |
| C | HIS105 |
| C | PRO325 |
| site_id | AI8 |
| Number of Residues | 13 |
| Details | binding site for residue D68 C 515 |
| Chain | Residue |
| C | HIS160 |
| C | MET273 |
| C | ASN321 |
| C | PRO322 |
| C | TRP332 |
| C | THR333 |
| C | ILE336 |
| C | PHE340 |
| C | MET357 |
| C | GLN369 |
| C | PHE372 |
| C | ILE376 |
| C | HOH674 |
| site_id | AI9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO C 516 |
| Chain | Residue |
| B | HIS389 |
| C | THR134 |
| C | PHE135 |
| C | LYS136 |
| C | ASN251 |
| C | GLN256 |
| site_id | AJ1 |
| Number of Residues | 6 |
| Details | binding site for residue EDO C 517 |
| Chain | Residue |
| C | ASN115 |
| C | ALA155 |
| C | ASN161 |
| C | ASN162 |
| C | ARG335 |
| C | HOH660 |
| site_id | AJ2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 518 |
| Chain | Residue |
| C | LYS262 |
| C | ASP266 |
| D | ASN224 |
| site_id | AJ3 |
| Number of Residues | 2 |
| Details | binding site for residue EDO D 501 |
| Chain | Residue |
| B | GLU349 |
| D | THR144 |
| site_id | AJ4 |
| Number of Residues | 10 |
| Details | binding site for residue PG4 D 502 |
| Chain | Residue |
| C | TYR223 |
| C | ASN231 |
| C | LEU234 |
| C | ALA235 |
| C | PHE238 |
| C | ARG261 |
| D | LEU221 |
| D | MET222 |
| D | ASN224 |
| D | HOH625 |
| site_id | AJ5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO D 503 |
| Chain | Residue |
| A | GLN258 |
| B | ASN214 |
| D | SER294 |
| D | SER295 |
| D | HOH618 |
| site_id | AJ6 |
| Number of Residues | 6 |
| Details | binding site for residue ZN D 504 |
| Chain | Residue |
| D | HIS164 |
| D | HIS200 |
| D | ASP201 |
| D | ASP318 |
| D | HOH617 |
| D | HOH715 |
| site_id | AJ7 |
| Number of Residues | 6 |
| Details | binding site for residue MG D 505 |
| Chain | Residue |
| D | ASP201 |
| D | HOH617 |
| D | HOH634 |
| D | HOH647 |
| D | HOH677 |
| D | HOH716 |
| site_id | AJ8 |
| Number of Residues | 7 |
| Details | binding site for residue EDO D 506 |
| Chain | Residue |
| A | THR134 |
| A | PHE135 |
| A | ASN251 |
| A | GLN256 |
| A | EDO508 |
| D | PRO179 |
| D | ASP391 |
| site_id | AJ9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 507 |
| Chain | Residue |
| D | SER259 |
| D | LYS262 |
| D | TYR303 |
| site_id | AK1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 508 |
| Chain | Residue |
| D | SER208 |
| D | PRO356 |
| D | CYS358 |
| D | HOH638 |
| site_id | AK2 |
| Number of Residues | 6 |
| Details | binding site for residue EDO D 509 |
| Chain | Residue |
| D | PHE238 |
| D | PHE249 |
| D | ARG257 |
| D | ARG261 |
| D | HOH643 |
| D | HOH691 |
| site_id | AK3 |
| Number of Residues | 10 |
| Details | binding site for residue EDO D 510 |
| Chain | Residue |
| D | HIS160 |
| D | HIS204 |
| D | GLY206 |
| D | VAL207 |
| D | SER208 |
| D | GLU339 |
| D | D68520 |
| D | HOH638 |
| D | HOH655 |
| D | HOH717 |
| site_id | AK4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO D 511 |
| Chain | Residue |
| B | THR215 |
| B | EDO508 |
| D | THR148 |
| D | HIS152 |
| D | GLU243 |
| site_id | AK5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 512 |
| Chain | Residue |
| C | HOH649 |
| D | LYS262 |
| D | ASP266 |
| site_id | AK6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 513 |
| Chain | Residue |
| D | ASN115 |
| D | ALA155 |
| D | ASN162 |
| D | ILE163 |
| site_id | AK7 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 514 |
| Chain | Residue |
| D | ARG129 |
| D | LEU131 |
| D | ASP187 |
| D | ILE190 |
| site_id | AK8 |
| Number of Residues | 7 |
| Details | binding site for residue EDO D 515 |
| Chain | Residue |
| D | LEU176 |
| D | LEU181 |
| D | ALA183 |
| D | VAL184 |
| D | PHE185 |
| D | ILE190 |
| D | HOH709 |
| site_id | AK9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO D 516 |
| Chain | Residue |
| A | LYS255 |
| A | GLN256 |
| A | SER259 |
| A | EDO521 |
| D | GLU182 |
| D | HOH604 |
| site_id | AL1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 517 |
| Chain | Residue |
| D | THR134 |
| D | LYS136 |
| D | ASN251 |
| D | GLN256 |
| site_id | AL2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO D 518 |
| Chain | Residue |
| C | SER226 |
| D | SER226 |
| D | ASN231 |
| D | HOH644 |
| D | HOH710 |
| site_id | AL3 |
| Number of Residues | 7 |
| Details | binding site for residue PEG D 519 |
| Chain | Residue |
| A | EDO508 |
| D | VAL174 |
| D | THR178 |
| D | TRP384 |
| D | VAL388 |
| D | ASP391 |
| D | ALA392 |
| site_id | AL4 |
| Number of Residues | 16 |
| Details | binding site for residue D68 D 520 |
| Chain | Residue |
| D | MET273 |
| D | LEU319 |
| D | ASN321 |
| D | PRO322 |
| D | TYR329 |
| D | TRP332 |
| D | THR333 |
| D | ILE336 |
| D | PHE340 |
| D | MET357 |
| D | SER368 |
| D | GLN369 |
| D | GLY371 |
| D | PHE372 |
| D | EDO510 |
| D | HOH690 |
| site_id | AL5 |
| Number of Residues | 8 |
| Details | binding site for residue EPE D 521 |
| Chain | Residue |
| D | HIS105 |
| D | VAL106 |
| D | PHE107 |
| D | ARG108 |
| D | GLU111 |
| D | GLN327 |
| D | LEU328 |
| D | GLN331 |
| site_id | AL6 |
| Number of Residues | 1 |
| Details | binding site for residue EDO D 522 |
| Chain | Residue |
| D | GLN393 |
| site_id | AL7 |
| Number of Residues | 1 |
| Details | binding site for residue EDO D 523 |
| Chain | Residue |
| D | HIS123 |
| site_id | AL8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 524 |
| Chain | Residue |
| D | MET273 |
| D | SER274 |
| D | HIS276 |
| D | MET277 |
| site_id | AL9 |
| Number of Residues | 2 |
| Details | binding site for residue EDO D 525 |
| Chain | Residue |
| D | SER355 |
| D | MET357 |
| site_id | AM1 |
| Number of Residues | 2 |
| Details | binding site for residue EDO D 526 |
| Chain | Residue |
| D | ASP266 |
| D | GLN311 |
| site_id | AM2 |
| Number of Residues | 5 |
| Details | binding site for residue NI D 527 |
| Chain | Residue |
| B | HIS154 |
| B | HOH628 |
| D | HIS154 |
| D | ASP156 |
| D | HOH671 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF |
| Chain | Residue | Details |
| A | HIS200-PHE211 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton donor => ECO:0000250|UniProtKB:Q07343 |
| Chain | Residue | Details |
| A | HIS160 | |
| B | HIS160 | |
| C | HIS160 | |
| D | HIS160 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7 |
| Chain | Residue | Details |
| A | HIS160 | |
| D | HIS160 | |
| D | ASN321 | |
| D | GLN369 | |
| A | ASN321 | |
| A | GLN369 | |
| B | HIS160 | |
| B | ASN321 | |
| B | GLN369 | |
| C | HIS160 | |
| C | ASN321 | |
| C | GLN369 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:2PW3 |
| Chain | Residue | Details |
| A | HIS164 | |
| B | HIS164 | |
| C | HIS164 | |
| D | HIS164 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3 |
| Chain | Residue | Details |
| A | HIS200 | |
| A | ASP318 | |
| B | HIS200 | |
| B | ASP318 | |
| C | HIS200 | |
| C | ASP318 | |
| D | HIS200 | |
| D | ASP318 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0007744|PDB:1PTW |
| Chain | Residue | Details |
| A | ASP201 | |
| A | PHE372 | |
| B | ASP201 | |
| B | PHE372 | |
| C | ASP201 | |
| C | PHE372 | |
| D | ASP201 | |
| D | PHE372 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) |
| Chain | Residue | Details |
| A | LYS85 | |
| B | LYS85 | |
| C | LYS85 | |
| D | LYS85 |
