6FE6

Solution structure of a last generation P2-P4 macrocyclic inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0008236	molecular_function	serine-type peptidase activity
A	0019087	biological_process	symbiont-mediated transformation of host cell

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue 4P2 A 201

Chain	Residue
A	GLN41
A	GLY137
A	SER139
A	PHE154
A	ARG155
A	ALA156
A	ALA157
A	VAL158
A	CYS159
A	ASP168
A	SER42
A	TYR56
A	HIS57
A	VAL78
A	ASP81
A	VAL132
A	LEU135
A	LYS136

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site_id	AC2
Number of Residues	5
Details	binding site for residue ZN A 202

Chain	Residue
A	CYS97
A	CYS99
A	CYS145
A	SER147
A	HIS149

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