6F94

Crystal Structure of E. coli GyraseB 24kDa in complex with 6-[(ethylcarbamoyl)amino]-4-[(3-methyphenyl)amino]-N-(3-methyphenyl)pyridine-3-carboxamide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A	0005524	molecular_function	ATP binding
A	0006265	biological_process	DNA topological change

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue D0H A 500

Chain	Residue
A	VAL43
A	PRO79
A	ILE94
A	ARG136
A	LEU197
A	HOH610
A	HOH633
A	ASN46
A	ALA47
A	GLU50
A	VAL71
A	ASP73
A	ARG76
A	GLY77
A	ILE78

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor (ATPase activity) => ECO:0000305|PubMed:10734094, ECO:0000305|PubMed:8248233

Chain	Residue	Details
A	GLU42

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:25202966, ECO:0000269|PubMed:25849408, ECO:0000305|PubMed:10734094

Chain	Residue	Details
A	TYR5

---

site_id	SWS_FT_FI3
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:10734094, ECO:0000269|PubMed:25202966, ECO:0000269|PubMed:25849408

Chain	Residue	Details
A	ASN46
A	ASP73
A	GLY102
A	TYR109
A	LEU115

---

site_id	SWS_FT_FI4
Number of Residues	7
Details	BINDING: BINDING => ECO:0000269|PubMed:25849408

Chain	Residue	Details
A	ILE94
A	VAL97
A	ALA100
A	LYS103
A	ASP105
A	GLY117
A	SER121

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 745

Chain

Residue

Details

---