6F91
Structure of the family GH92 alpha-mannosidase BT3965 from Bacteroides thetaiotaomicron
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000224 | molecular_function | peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006516 | biological_process | glycoprotein catabolic process |
| A | 0030246 | molecular_function | carbohydrate binding |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000224 | molecular_function | peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006516 | biological_process | glycoprotein catabolic process |
| B | 0030246 | molecular_function | carbohydrate binding |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000224 | molecular_function | peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0006516 | biological_process | glycoprotein catabolic process |
| C | 0030246 | molecular_function | carbohydrate binding |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000224 | molecular_function | peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0006516 | biological_process | glycoprotein catabolic process |
| D | 0030246 | molecular_function | carbohydrate binding |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0000224 | molecular_function | peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity |
| E | 0005829 | cellular_component | cytosol |
| E | 0005975 | biological_process | carbohydrate metabolic process |
| E | 0006516 | biological_process | glycoprotein catabolic process |
| E | 0030246 | molecular_function | carbohydrate binding |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0000224 | molecular_function | peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity |
| F | 0005829 | cellular_component | cytosol |
| F | 0005975 | biological_process | carbohydrate metabolic process |
| F | 0006516 | biological_process | glycoprotein catabolic process |
| F | 0030246 | molecular_function | carbohydrate binding |
| F | 0046872 | molecular_function | metal ion binding |
| G | 0000224 | molecular_function | peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity |
| G | 0005829 | cellular_component | cytosol |
| G | 0005975 | biological_process | carbohydrate metabolic process |
| G | 0006516 | biological_process | glycoprotein catabolic process |
| G | 0030246 | molecular_function | carbohydrate binding |
| G | 0046872 | molecular_function | metal ion binding |
| H | 0000224 | molecular_function | peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity |
| H | 0005829 | cellular_component | cytosol |
| H | 0005975 | biological_process | carbohydrate metabolic process |
| H | 0006516 | biological_process | glycoprotein catabolic process |
| H | 0030246 | molecular_function | carbohydrate binding |
| H | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 801 |
| Chain | Residue |
| A | PRO96 |
| A | GLY99 |
| A | ARG101 |
| A | HOH1185 |
| A | HOH1208 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 802 |
| Chain | Residue |
| A | HOH1191 |
| A | HOH1410 |
| A | GLY589 |
| A | GLU591 |
| A | ASP633 |
| A | HOH1046 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue CL A 803 |
| Chain | Residue |
| A | LYS408 |
| A | PRO653 |
| A | SER654 |
| A | ASN656 |
| A | HOH1021 |
| A | HOH1086 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 804 |
| Chain | Residue |
| A | THR69 |
| A | GLY70 |
| A | TRP184 |
| A | HOH928 |
| A | HOH1004 |
| A | HOH1523 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | binding site for residue EDO A 805 |
| Chain | Residue |
| A | LEU200 |
| A | LEU203 |
| A | ARG204 |
| A | SER222 |
| A | TYR223 |
| A | HOH906 |
| A | HOH919 |
| A | HOH1066 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 806 |
| Chain | Residue |
| A | MET440 |
| A | SER504 |
| A | HOH901 |
| A | HOH1304 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue NA B 801 |
| Chain | Residue |
| B | PRO96 |
| B | GLY99 |
| B | ARG101 |
| B | HOH1173 |
| B | HOH1233 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 802 |
| Chain | Residue |
| B | GLY589 |
| B | GLU591 |
| B | ASP633 |
| B | HOH1032 |
| B | HOH1271 |
| B | HOH1396 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue CL B 803 |
| Chain | Residue |
| B | LYS408 |
| B | PRO653 |
| B | SER654 |
| B | ASN656 |
| site_id | AD1 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 804 |
| Chain | Residue |
| B | THR69 |
| B | GLY70 |
| B | ILE71 |
| B | TRP383 |
| B | CYS392 |
| B | HOH949 |
| B | HOH1147 |
| B | HOH1480 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 805 |
| Chain | Residue |
| B | LEU200 |
| B | LEU203 |
| B | ARG204 |
| B | SER222 |
| B | TYR223 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 806 |
| Chain | Residue |
| B | LYS497 |
| B | TYR498 |
| B | THR538 |
| B | TYR548 |
| B | ARG560 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue NA C 801 |
| Chain | Residue |
| C | PRO96 |
| C | GLY99 |
| C | ARG101 |
| C | HOH1140 |
| C | HOH1596 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue CA C 802 |
| Chain | Residue |
| C | GLY589 |
| C | GLU591 |
| C | ASP633 |
| C | HOH1263 |
| C | HOH1315 |
| C | HOH1497 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue CL C 803 |
| Chain | Residue |
| C | LYS408 |
| C | PRO653 |
| C | SER654 |
| C | ASN656 |
| C | HOH1021 |
| site_id | AD7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO C 804 |
| Chain | Residue |
| C | LYS497 |
| C | TYR498 |
| C | THR538 |
| C | TRP539 |
| C | TYR548 |
| C | ARG560 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO C 805 |
| Chain | Residue |
| C | LEU200 |
| C | LEU203 |
| C | ARG204 |
| C | SER222 |
| C | HOH905 |
| C | HOH943 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO C 806 |
| Chain | Residue |
| C | GLY589 |
| C | SER629 |
| C | HOH907 |
| C | GLN580 |
| C | TRP587 |
| C | HIS588 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue NA D 801 |
| Chain | Residue |
| D | PRO96 |
| D | GLY99 |
| D | ARG101 |
| D | HOH1282 |
| D | HOH1566 |
| site_id | AE2 |
| Number of Residues | 6 |
| Details | binding site for residue CA D 802 |
| Chain | Residue |
| D | GLY589 |
| D | GLU591 |
| D | ASP633 |
| D | HOH1066 |
| D | HOH1205 |
| D | HOH1500 |
| site_id | AE3 |
| Number of Residues | 5 |
| Details | binding site for residue CL D 803 |
| Chain | Residue |
| D | LYS408 |
| D | PRO653 |
| D | SER654 |
| D | ASN656 |
| D | HOH1004 |
| site_id | AE4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO D 804 |
| Chain | Residue |
| D | LYS497 |
| D | TYR498 |
| D | THR538 |
| D | TYR548 |
| D | ALA552 |
| D | ARG560 |
| site_id | AE5 |
| Number of Residues | 7 |
| Details | binding site for residue EDO D 805 |
| Chain | Residue |
| D | THR289 |
| D | LEU290 |
| D | THR291 |
| D | ALA667 |
| D | THR669 |
| D | HOH959 |
| D | HOH1299 |
| site_id | AE6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO D 806 |
| Chain | Residue |
| D | THR69 |
| D | GLY70 |
| D | TRP184 |
| D | TRP383 |
| D | HOH902 |
| D | HOH1128 |
| D | HOH1254 |
| site_id | AE7 |
| Number of Residues | 2 |
| Details | binding site for residue EDO D 807 |
| Chain | Residue |
| D | THR195 |
| D | THR245 |
| site_id | AE8 |
| Number of Residues | 8 |
| Details | binding site for residue EDO D 808 |
| Chain | Residue |
| D | THR302 |
| D | SER303 |
| D | HIS306 |
| D | TYR621 |
| D | LEU628 |
| D | SER638 |
| D | HOH1200 |
| D | HOH1252 |
| site_id | AE9 |
| Number of Residues | 5 |
| Details | binding site for residue NA E 801 |
| Chain | Residue |
| E | PRO96 |
| E | GLY99 |
| E | ARG101 |
| E | HOH1193 |
| E | HOH1391 |
| site_id | AF1 |
| Number of Residues | 6 |
| Details | binding site for residue CA E 802 |
| Chain | Residue |
| E | GLY589 |
| E | GLU591 |
| E | ASP633 |
| E | HOH1285 |
| E | HOH1392 |
| E | HOH1534 |
| site_id | AF2 |
| Number of Residues | 5 |
| Details | binding site for residue CL E 803 |
| Chain | Residue |
| E | LYS408 |
| E | PRO653 |
| E | SER654 |
| E | ASN656 |
| E | HOH1077 |
| site_id | AF3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO E 804 |
| Chain | Residue |
| E | THR195 |
| E | THR245 |
| E | LYS247 |
| site_id | AF4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO E 805 |
| Chain | Residue |
| E | THR69 |
| E | GLY70 |
| E | TRP383 |
| E | HOH1282 |
| E | HOH1422 |
| site_id | AF5 |
| Number of Residues | 6 |
| Details | binding site for residue EDO E 806 |
| Chain | Residue |
| E | LYS497 |
| E | TYR498 |
| E | THR538 |
| E | TRP539 |
| E | TYR548 |
| E | ARG560 |
| site_id | AF6 |
| Number of Residues | 5 |
| Details | binding site for residue NA F 801 |
| Chain | Residue |
| F | PRO96 |
| F | GLY99 |
| F | ARG101 |
| F | HOH997 |
| F | HOH1102 |
| site_id | AF7 |
| Number of Residues | 6 |
| Details | binding site for residue CA F 802 |
| Chain | Residue |
| F | GLY589 |
| F | GLU591 |
| F | ASP633 |
| F | HOH1157 |
| F | HOH1252 |
| F | HOH1318 |
| site_id | AF8 |
| Number of Residues | 6 |
| Details | binding site for residue CL F 803 |
| Chain | Residue |
| F | LYS408 |
| F | PRO653 |
| F | SER654 |
| F | ASN656 |
| F | HOH1111 |
| F | HOH1143 |
| site_id | AF9 |
| Number of Residues | 3 |
| Details | binding site for residue EDO F 804 |
| Chain | Residue |
| F | THR195 |
| F | THR245 |
| F | LYS247 |
| site_id | AG1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO F 805 |
| Chain | Residue |
| F | MET440 |
| F | SER504 |
| F | HOH1094 |
| site_id | AG2 |
| Number of Residues | 5 |
| Details | binding site for residue NA G 801 |
| Chain | Residue |
| G | PRO96 |
| G | GLY99 |
| G | ARG101 |
| G | HOH1099 |
| G | HOH1227 |
| site_id | AG3 |
| Number of Residues | 7 |
| Details | binding site for residue CA G 802 |
| Chain | Residue |
| G | GLY589 |
| G | GLU591 |
| G | ASP633 |
| G | HOH1220 |
| G | HOH1283 |
| G | HOH1375 |
| G | HOH1594 |
| site_id | AG4 |
| Number of Residues | 4 |
| Details | binding site for residue CL G 803 |
| Chain | Residue |
| G | LYS408 |
| G | PRO653 |
| G | SER654 |
| G | ASN656 |
| site_id | AG5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO G 804 |
| Chain | Residue |
| G | THR195 |
| G | THR245 |
| G | LYS247 |
| site_id | AG6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO G 805 |
| Chain | Residue |
| G | THR289 |
| G | LEU290 |
| G | THR291 |
| G | THR669 |
| site_id | AG7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO G 806 |
| Chain | Residue |
| G | TYR480 |
| G | ASN483 |
| G | ARG484 |
| G | HOH910 |
| G | HOH953 |
| G | HOH1440 |
| site_id | AG8 |
| Number of Residues | 7 |
| Details | binding site for residue EDO G 807 |
| Chain | Residue |
| G | LYS497 |
| G | TYR498 |
| G | THR538 |
| G | TRP539 |
| G | TYR548 |
| G | ARG560 |
| G | HOH1381 |
| site_id | AG9 |
| Number of Residues | 5 |
| Details | binding site for residue NA H 801 |
| Chain | Residue |
| H | PRO96 |
| H | GLY99 |
| H | ARG101 |
| H | HOH3407 |
| H | HOH3420 |
| site_id | AH1 |
| Number of Residues | 7 |
| Details | binding site for residue CA H 802 |
| Chain | Residue |
| H | GLY589 |
| H | GLU591 |
| H | ASP633 |
| H | HOH3122 |
| H | HOH3312 |
| H | HOH3482 |
| H | HOH3693 |
| site_id | AH2 |
| Number of Residues | 5 |
| Details | binding site for residue CL H 803 |
| Chain | Residue |
| H | LYS408 |
| H | PRO653 |
| H | SER654 |
| H | ASN656 |
| H | HOH3340 |
| site_id | AH3 |
| Number of Residues | 7 |
| Details | binding site for residue EDO H 804 |
| Chain | Residue |
| H | LYS497 |
| H | TYR498 |
| H | THR538 |
| H | TYR548 |
| H | ALA552 |
| H | ARG560 |
| H | HOH3627 |
| site_id | AH4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO H 805 |
| Chain | Residue |
| H | THR195 |
| H | THR245 |
| H | LYS247 |
| site_id | AH5 |
| Number of Residues | 7 |
| Details | binding site for residue EDO H 806 |
| Chain | Residue |
| H | TYR480 |
| H | ASN483 |
| H | ARG484 |
| H | HOH3101 |
| H | HOH3105 |
| H | HOH3147 |
| H | HOH3238 |
