6F8V

Crystal structure of the PDE4D catalytic domain in complex with GEBR-18b

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
A	0007165	biological_process	signal transduction
A	0008081	molecular_function	phosphoric diester hydrolase activity
B	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
B	0007165	biological_process	signal transduction
B	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue ZN A 601

Chain	Residue
A	HIS330
A	HIS366
A	ASP367
A	ASP484
A	HOH731
A	HOH814

---

site_id	AC2
Number of Residues	6
Details	binding site for residue MG A 602

Chain	Residue
A	HOH803
A	HOH817
A	HOH906
A	ASP367
A	HOH731
A	HOH748

---

site_id	AC3
Number of Residues	3
Details	binding site for residue MG A 603

Chain	Residue
A	ASP264
A	HOH710
A	HOH798

---

site_id	AC4
Number of Residues	6
Details	binding site for residue MG A 604

Chain	Residue
A	ASP467
A	ASP471
A	HIS527
A	HOH800
A	HOH809
A	HOH820

---

site_id	AC5
Number of Residues	14
Details	binding site for residue D0B A 605

Chain	Residue
A	TYR325
A	THR437
A	MET439
A	ASP484
A	LEU485
A	ASN487
A	ILE502
A	PHE506
A	MET523
A	GLN535
A	PHE538
A	HOH737
A	HOH834
A	HOH873

---

site_id	AC6
Number of Residues	6
Details	binding site for residue ZN B 601

Chain	Residue
B	HIS330
B	HIS366
B	ASP367
B	ASP484
B	HOH712
B	HOH753

---

site_id	AC7
Number of Residues	6
Details	binding site for residue MG B 602

Chain	Residue
B	ASP367
B	HOH712
B	HOH751
B	HOH779
B	HOH801
B	HOH807

---

site_id	AC8
Number of Residues	13
Details	binding site for residue D0B B 603

Chain	Residue
B	THR437
B	MET439
B	ASP484
B	LEU485
B	ASN487
B	THR499
B	ILE502
B	PHE506
B	MET523
B	GLN535
B	PHE538
B	HOH787
B	HOH812

---

Functional Information from PROSITE/UniProt

site_id	PS00126
Number of Residues	12
Details	PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF

Chain	Residue	Details
A	HIS366-PHE377

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton donor => ECO:0000250|UniProtKB:Q07343

Chain	Residue	Details
A	GLY462
B	GLY462

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7

Chain	Residue	Details
A	GLY462
B	GLY462

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:2PW3

Chain	Residue	Details
A	LEU466
B	LEU466

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3

Chain	Residue	Details
B	ILE502
A	ILE502

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0007744|PDB:1PTW

Chain	Residue	Details
B	MET503
A	MET503

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692

Chain	Residue	Details
B	LYS299
B	PHE301
A	LYS299
A	PHE301

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	ASN375
B	ASN375
B	GLU348
A	GLU348

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)

Chain	Residue	Details
A	LEU387
B	LEU387

---