6F8R

Crystal structure of the PDE4D catalytic domain in complex with GEBR-54

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
A	0007165	biological_process	signal transduction
A	0008081	molecular_function	phosphoric diester hydrolase activity
B	0004114	molecular_function	3',5'-cyclic-nucleotide phosphodiesterase activity
B	0007165	biological_process	signal transduction
B	0008081	molecular_function	phosphoric diester hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue CZK A 601

Chain	Residue
A	TYR325
A	HOH825
A	HOH995
A	HIS326
A	SER374
A	ASN487
A	PHE506
A	PRO522
A	MET523
A	GLN535
A	PHE538

---

site_id	AC2
Number of Residues	7
Details	binding site for residue MG A 602

Chain	Residue
A	ASP367
A	ZN605
A	HOH726
A	HOH781
A	HOH832
A	HOH844
A	HOH906

---

site_id	AC3
Number of Residues	6
Details	binding site for residue MG A 603

Chain	Residue
A	ASP467
A	ASP471
A	HIS527
A	HOH770
A	HOH816
A	HOH834

---

site_id	AC4
Number of Residues	3
Details	binding site for residue MG A 604

Chain	Residue
A	ASN417
A	HOH713
A	HOH843

---

site_id	AC5
Number of Residues	7
Details	binding site for residue ZN A 605

Chain	Residue
A	HIS330
A	HIS366
A	ASP367
A	ASP484
A	MG602
A	HOH726
A	HOH864

---

site_id	AC6
Number of Residues	8
Details	binding site for residue CZK B 601

Chain	Residue
B	TYR325
B	MET439
B	ASN487
B	MET503
B	MET523
B	SER534
B	GLN535
B	PHE538

---

site_id	AC7
Number of Residues	7
Details	binding site for residue MG B 602

Chain	Residue
B	ASP367
B	ZN603
B	HOH722
B	HOH760
B	HOH831
B	HOH858
B	HOH861

---

site_id	AC8
Number of Residues	7
Details	binding site for residue ZN B 603

Chain	Residue
B	HIS330
B	HIS366
B	ASP367
B	ASP484
B	MG602
B	HOH722
B	HOH863

---

site_id	AC9
Number of Residues	5
Details	binding site for residue EDO B 604

Chain	Residue
A	ASN390
A	HOH779
B	LYS428
B	ILE431
B	ASP432

---

Functional Information from PROSITE/UniProt

site_id	PS00126
Number of Residues	12
Details	PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF

Chain	Residue	Details
A	HIS366-PHE377

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"Q07343","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14609333","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15260978","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PTW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TB7","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14609333","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15260978","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15576036","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17582435","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PTW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TB7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TBB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XON","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PW3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14609333","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15260978","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15576036","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17582435","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PTW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TB7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TBB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XON","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XOR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PW3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"14609333","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PTW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---