6F5T
Crystal Structure of KDM4D with tetrazole ligand GF057
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 401 |
| Chain | Residue |
| A | CYS238 |
| A | HIS244 |
| A | CYS310 |
| A | CYS312 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 402 |
| Chain | Residue |
| A | ARG102 |
| A | HIS103 |
| A | ASN106 |
| A | HOH501 |
| A | HOH507 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 403 |
| Chain | Residue |
| A | ASN65 |
| A | ILE66 |
| A | SER67 |
| A | ARG102 |
| A | HOH643 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 404 |
| Chain | Residue |
| A | PRO113 |
| A | LYS124 |
| A | ASN128 |
| A | TRP185 |
| A | LYS186 |
| A | HOH608 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 405 |
| Chain | Residue |
| A | ARG123 |
| A | LYS124 |
| A | LYS127 |
| A | ASN128 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue NI A 406 |
| Chain | Residue |
| A | HIS192 |
| A | GLU194 |
| A | HIS280 |
| A | CQK407 |
| A | HOH544 |
| site_id | AC7 |
| Number of Residues | 15 |
| Details | binding site for residue CQK A 407 |
| Chain | Residue |
| A | TYR136 |
| A | TYR181 |
| A | PHE189 |
| A | HIS192 |
| A | GLU194 |
| A | LYS210 |
| A | TRP212 |
| A | LYS245 |
| A | HIS280 |
| A | NI406 |
| A | HOH518 |
| A | HOH544 |
| A | HOH605 |
| A | HOH652 |
| A | HOH720 |
| site_id | AC8 |
| Number of Residues | 14 |
| Details | binding site for residue EPE A 408 |
| Chain | Residue |
| A | PHE21 |
| A | HIS22 |
| A | TYR34 |
| A | TYR37 |
| A | GLN41 |
| A | GLU256 |
| A | GLY258 |
| A | EPE409 |
| A | HOH513 |
| A | HOH586 |
| A | HOH612 |
| A | HOH666 |
| A | HOH787 |
| A | HOH795 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue EPE A 409 |
| Chain | Residue |
| A | GLU27 |
| A | LYS33 |
| A | TYR34 |
| A | TYR37 |
| A | EPE408 |
| A | HOH589 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 410 |
| Chain | Residue |
| A | MET306 |
| A | HOH531 |
| A | HOH786 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 411 |
| Chain | Residue |
| A | ARG263 |
| A | ILE264 |
| A | THR265 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 412 |
| Chain | Residue |
| A | PHE28 |
| A | ASP30 |
| A | PHE31 |
| A | GLN151 |
| A | TRP152 |
| A | HOH746 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 42 |
| Details | Domain: {"description":"JmjN","evidences":[{"source":"PROSITE-ProRule","id":"PRU00537","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 166 |
| Details | Domain: {"description":"JmjC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"B2RXH2","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26741168","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"5F5A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F5C","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"PolyADP-ribosyl glutamic acid","evidences":[{"source":"PubMed","id":"23102699","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
