Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6F5P

A mechanism for the activation of the influenza virus transcriptase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0004518	molecular_function	nuclease activity
A	0004519	molecular_function	endonuclease activity
A	0006351	biological_process	DNA-templated transcription
A	0016787	molecular_function	hydrolase activity
A	0030430	cellular_component	host cell cytoplasm
A	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
A	0039657	biological_process	symbiont-mediated suppression of host gene expression
A	0039694	biological_process	viral RNA genome replication
A	0042025	cellular_component	host cell nucleus
A	0046872	molecular_function	metal ion binding
A	0075523	biological_process	viral translational frameshifting
A	0075526	biological_process	cap snatching
B	0000166	molecular_function	nucleotide binding
B	0001172	biological_process	RNA-templated transcription
B	0003723	molecular_function	RNA binding
B	0003968	molecular_function	RNA-directed RNA polymerase activity
B	0006351	biological_process	DNA-templated transcription
B	0016740	molecular_function	transferase activity
B	0016779	molecular_function	nucleotidyltransferase activity
B	0019083	biological_process	viral transcription
B	0030430	cellular_component	host cell cytoplasm
B	0034062	molecular_function	5'-3' RNA polymerase activity
B	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
B	0039657	biological_process	symbiont-mediated suppression of host gene expression
B	0039694	biological_process	viral RNA genome replication
B	0042025	cellular_component	host cell nucleus
C	0000166	molecular_function	nucleotide binding
C	0001172	biological_process	RNA-templated transcription
C	0003723	molecular_function	RNA binding
C	0003968	molecular_function	RNA-directed RNA polymerase activity
C	0006351	biological_process	DNA-templated transcription
C	0016740	molecular_function	transferase activity
C	0016779	molecular_function	nucleotidyltransferase activity
C	0019083	biological_process	viral transcription
C	0030430	cellular_component	host cell cytoplasm
C	0034062	molecular_function	5'-3' RNA polymerase activity
C	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
C	0039657	biological_process	symbiont-mediated suppression of host gene expression
C	0039694	biological_process	viral RNA genome replication
C	0042025	cellular_component	host cell nucleus
D	0003723	molecular_function	RNA binding
D	0004518	molecular_function	nuclease activity
D	0004519	molecular_function	endonuclease activity
D	0006351	biological_process	DNA-templated transcription
D	0016787	molecular_function	hydrolase activity
D	0030430	cellular_component	host cell cytoplasm
D	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
D	0039657	biological_process	symbiont-mediated suppression of host gene expression
D	0039694	biological_process	viral RNA genome replication
D	0042025	cellular_component	host cell nucleus
D	0046872	molecular_function	metal ion binding
D	0075523	biological_process	viral translational frameshifting
D	0075526	biological_process	cap snatching
E	0001172	biological_process	RNA-templated transcription
E	0003723	molecular_function	RNA binding
E	0003968	molecular_function	RNA-directed RNA polymerase activity
E	0006351	biological_process	DNA-templated transcription
E	0006370	biological_process	7-methylguanosine mRNA capping
E	0006397	biological_process	mRNA processing
E	0019083	biological_process	viral transcription
E	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
E	0039657	biological_process	symbiont-mediated suppression of host gene expression
E	0039694	biological_process	viral RNA genome replication
E	0042025	cellular_component	host cell nucleus
E	0044423	cellular_component	virion component
E	0075526	biological_process	cap snatching
F	0001172	biological_process	RNA-templated transcription
F	0003723	molecular_function	RNA binding
F	0003968	molecular_function	RNA-directed RNA polymerase activity
F	0006351	biological_process	DNA-templated transcription
F	0006370	biological_process	7-methylguanosine mRNA capping
F	0006397	biological_process	mRNA processing
F	0019083	biological_process	viral transcription
F	0039523	biological_process	symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
F	0039657	biological_process	symbiont-mediated suppression of host gene expression
F	0039694	biological_process	viral RNA genome replication
F	0042025	cellular_component	host cell nucleus
F	0044423	cellular_component	virion component
F	0075526	biological_process	cap snatching
G	0003677	molecular_function	DNA binding
G	0006366	biological_process	transcription by RNA polymerase II

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue MG A 800

Chain	Residue
A	HIS41
A	ASP93
A	GLU104
A	MG801

site_id	AC2
Number of Residues	5
Details	binding site for residue MG A 801

Chain	Residue
A	GLU65
A	LEU91
A	ASP93
A	GLU104
A	MG800

site_id	AC3
Number of Residues	4
Details	binding site for residue MG D 800

Chain	Residue
D	HIS41
D	ASP93
D	GLU104
D	MG801

site_id	AC4
Number of Residues	5
Details	binding site for residue MG D 801

Chain	Residue
D	GLU65
D	LEU91
D	ASP93
D	GLU104
D	MG800

Functional Information from PROSITE/UniProt

site_id	PS00115
Number of Residues	7
Details	RNA_POL_II_REPEAT Eukaryotic RNA polymerase II heptapeptide repeat. YSPTSPS

Chain	Residue	Details
G	TYR1-SER7
G	TYR8-SER14
G	TYR15-SER21
G	TYR22-SER28

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	Motif: {"description":"Nuclear localization signal 1 (NLS1)","evidences":[{"source":"HAMAP-Rule","id":"MF_04063","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	124
Details	Motif: {"description":"Nuclear localization signal 2 (NLS2)","evidences":[{"source":"HAMAP-Rule","id":"MF_04063","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04063","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	392
Details	Domain: {"description":"RdRp catalytic","evidences":[{"source":"HAMAP-Rule","id":"MF_04065","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	14
Details	Region: {"description":"Promoter-binding site","evidences":[{"source":"HAMAP-Rule","id":"MF_04065","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	26
Details	Motif: {"description":"Nuclear localization signal","evidences":[{"source":"HAMAP-Rule","id":"MF_04065","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	6
Details	Repeat: {"description":"19","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)