Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6F5D

Trypanosoma brucei F1-ATPase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000275	cellular_component	obsolete mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)
A	0005524	molecular_function	ATP binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0006754	biological_process	ATP biosynthetic process
A	0006811	biological_process	monoatomic ion transport
A	0015986	biological_process	proton motive force-driven ATP synthesis
A	0016020	cellular_component	membrane
A	0032559	molecular_function	adenyl ribonucleotide binding
A	0043531	molecular_function	ADP binding
A	0045259	cellular_component	proton-transporting ATP synthase complex
A	0046872	molecular_function	metal ion binding
A	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
A	1902600	biological_process	proton transmembrane transport
B	0000166	molecular_function	nucleotide binding
B	0000275	cellular_component	obsolete mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)
B	0005524	molecular_function	ATP binding
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0006754	biological_process	ATP biosynthetic process
B	0006811	biological_process	monoatomic ion transport
B	0015986	biological_process	proton motive force-driven ATP synthesis
B	0016020	cellular_component	membrane
B	0032559	molecular_function	adenyl ribonucleotide binding
B	0043531	molecular_function	ADP binding
B	0045259	cellular_component	proton-transporting ATP synthase complex
B	0046872	molecular_function	metal ion binding
B	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
B	1902600	biological_process	proton transmembrane transport
C	0000166	molecular_function	nucleotide binding
C	0000275	cellular_component	obsolete mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)
C	0005524	molecular_function	ATP binding
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0006754	biological_process	ATP biosynthetic process
C	0006811	biological_process	monoatomic ion transport
C	0015986	biological_process	proton motive force-driven ATP synthesis
C	0016020	cellular_component	membrane
C	0032559	molecular_function	adenyl ribonucleotide binding
C	0043531	molecular_function	ADP binding
C	0045259	cellular_component	proton-transporting ATP synthase complex
C	0046872	molecular_function	metal ion binding
C	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
C	1902600	biological_process	proton transmembrane transport
D	0000166	molecular_function	nucleotide binding
D	0000275	cellular_component	obsolete mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005525	molecular_function	GTP binding
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0006754	biological_process	ATP biosynthetic process
D	0006811	biological_process	monoatomic ion transport
D	0015986	biological_process	proton motive force-driven ATP synthesis
D	0016020	cellular_component	membrane
D	0016787	molecular_function	hydrolase activity
D	0020023	cellular_component	kinetoplast
D	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
D	0045259	cellular_component	proton-transporting ATP synthase complex
D	0046034	biological_process	ATP metabolic process
D	0046872	molecular_function	metal ion binding
D	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
D	1902600	biological_process	proton transmembrane transport
E	0000166	molecular_function	nucleotide binding
E	0000275	cellular_component	obsolete mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005525	molecular_function	GTP binding
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0006754	biological_process	ATP biosynthetic process
E	0006811	biological_process	monoatomic ion transport
E	0015986	biological_process	proton motive force-driven ATP synthesis
E	0016020	cellular_component	membrane
E	0016787	molecular_function	hydrolase activity
E	0020023	cellular_component	kinetoplast
E	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
E	0045259	cellular_component	proton-transporting ATP synthase complex
E	0046034	biological_process	ATP metabolic process
E	0046872	molecular_function	metal ion binding
E	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
E	1902600	biological_process	proton transmembrane transport
F	0000166	molecular_function	nucleotide binding
F	0000275	cellular_component	obsolete mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005525	molecular_function	GTP binding
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0006754	biological_process	ATP biosynthetic process
F	0006811	biological_process	monoatomic ion transport
F	0015986	biological_process	proton motive force-driven ATP synthesis
F	0016020	cellular_component	membrane
F	0016787	molecular_function	hydrolase activity
F	0020023	cellular_component	kinetoplast
F	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
F	0045259	cellular_component	proton-transporting ATP synthase complex
F	0046034	biological_process	ATP metabolic process
F	0046872	molecular_function	metal ion binding
F	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
F	1902600	biological_process	proton transmembrane transport
G	0000275	cellular_component	obsolete mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)
G	0005739	cellular_component	mitochondrion
G	0006754	biological_process	ATP biosynthetic process
G	0006811	biological_process	monoatomic ion transport
G	0015986	biological_process	proton motive force-driven ATP synthesis
G	0016020	cellular_component	membrane
G	0016469	cellular_component	proton-transporting two-sector ATPase complex
G	0016787	molecular_function	hydrolase activity
G	0045259	cellular_component	proton-transporting ATP synthase complex
G	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
G	0046961	molecular_function	proton-transporting ATPase activity, rotational mechanism
G	1902600	biological_process	proton transmembrane transport
H	0000275	cellular_component	obsolete mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0006811	biological_process	monoatomic ion transport
H	0015986	biological_process	proton motive force-driven ATP synthesis
H	0016020	cellular_component	membrane
H	0016787	molecular_function	hydrolase activity
H	0045259	cellular_component	proton-transporting ATP synthase complex
H	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
H	1902600	biological_process	proton transmembrane transport
I	0005743	cellular_component	mitochondrial inner membrane
I	0015986	biological_process	proton motive force-driven ATP synthesis
I	0045259	cellular_component	proton-transporting ATP synthase complex
I	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
J	0000276	cellular_component	obsolete mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
J	0005515	molecular_function	protein binding
J	0005739	cellular_component	mitochondrion
J	0020023	cellular_component	kinetoplast
J	1990904	cellular_component	ribonucleoprotein complex
K	0000276	cellular_component	obsolete mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
K	0005515	molecular_function	protein binding
K	0005739	cellular_component	mitochondrion
K	0020023	cellular_component	kinetoplast
K	1990904	cellular_component	ribonucleoprotein complex
L	0000276	cellular_component	obsolete mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
L	0005515	molecular_function	protein binding
L	0005739	cellular_component	mitochondrion
L	0020023	cellular_component	kinetoplast
L	1990904	cellular_component	ribonucleoprotein complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue ADP A 600

Chain	Residue
A	ASP183
A	PRO376
A	GLN440
A	LYS441
A	MG601
A	HOH701
A	HOH703
A	HOH704
A	GLN185
A	THR186
A	GLY187
A	LYS188
A	THR189
A	SER190
A	PHE370
A	ARG375

site_id	AC2
Number of Residues	6
Details	binding site for residue MG A 601

Chain	Residue
A	THR189
A	ADP600
A	HOH701
A	HOH702
A	HOH703
A	HOH704

site_id	AC3
Number of Residues	17
Details	binding site for residue ADP B 600

Chain	Residue
B	ASP183
B	GLN185
B	THR186
B	GLY187
B	LYS188
B	THR189
B	SER190
B	PHE370
B	ARG375
B	PRO376
B	GLN440
B	LYS441
B	MG601
B	HOH701
B	HOH703
B	HOH704
E	ASP364

site_id	AC4
Number of Residues	6
Details	binding site for residue MG B 601

Chain	Residue
B	THR189
B	ADP600
B	HOH701
B	HOH702
B	HOH703
B	HOH704

site_id	AC5
Number of Residues	14
Details	binding site for residue ADP C 600

Chain	Residue
C	ASP183
C	GLN185
C	THR186
C	GLY187
C	LYS188
C	THR189
C	SER190
C	ARG375
C	PRO376
C	GLN440
C	MG601
C	HOH701
C	HOH704
F	ARG361

site_id	AC6
Number of Residues	6
Details	binding site for residue MG C 601

Chain	Residue
C	THR189
C	ADP600
C	HOH701
C	HOH702
C	HOH703
C	HOH704

site_id	AC7
Number of Residues	15
Details	binding site for residue ADP D 600

Chain	Residue
C	SER385
C	ARG386
D	GLY165
D	VAL166
D	GLY167
D	LYS168
D	THR169
D	VAL170
D	TYR350
D	PHE423
D	ALA426
D	PHE429
D	MG601
D	HOH701
D	HOH704

site_id	AC8
Number of Residues	6
Details	binding site for residue MG D 601

Chain	Residue
D	THR169
D	ADP600
D	HOH701
D	HOH702
D	HOH703
D	HOH704

site_id	AC9
Number of Residues	8
Details	binding site for residue ADP E 600

Chain	Residue
E	GLY165
E	GLY167
E	LYS168
E	THR169
E	VAL170
E	TYR350
E	PHE429
E	THR430

site_id	AD1
Number of Residues	13
Details	binding site for residue ADP F 600

Chain	Residue
F	LYS168
F	THR169
F	VAL170
F	TYR350
F	PHE429
F	THR430
F	MG601
F	HOH701
B	VAL384
B	ARG386
F	GLY165
F	VAL166
F	GLY167

site_id	AD2
Number of Residues	6
Details	binding site for residue MG F 601

Chain	Residue
F	THR169
F	ADP600
F	HOH701
F	HOH702
F	HOH703
F	HOH704

Functional Information from PROSITE/UniProt

site_id	PS00152
Number of Residues	10
Details	ATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PAVNIGLSVS

Chain	Residue	Details
A	PRO376-SER385

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269\|PubMed:29440423, ECO:0007744\|PDB:6F5D

Chain	Residue	Details
D	GLY163
E	GLY163
F	GLY163
B	GLN440
C	ASP183
C	GLN440

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P00829

Chain	Residue	Details
D	ARG195
E	ARG195
F	ARG195

site_id	SWS_FT_FI3
Number of Residues	3
Details	SITE: Required for activity => ECO:0000255\|PROSITE-ProRule:PRU10106

Chain	Residue	Details
A	SER383
B	SER383
C	SER383

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)