6F4W
Crystal structure of H. pylori purine nucleoside phosphorylase in complex with formycin A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| A | 0006152 | biological_process | purine nucleoside catabolic process |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| B | 0006152 | biological_process | purine nucleoside catabolic process |
| B | 0009116 | biological_process | nucleoside metabolic process |
| B | 0016763 | molecular_function | pentosyltransferase activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| C | 0005829 | cellular_component | cytosol |
| C | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| C | 0006152 | biological_process | purine nucleoside catabolic process |
| C | 0009116 | biological_process | nucleoside metabolic process |
| C | 0016763 | molecular_function | pentosyltransferase activity |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| D | 0006152 | biological_process | purine nucleoside catabolic process |
| D | 0009116 | biological_process | nucleoside metabolic process |
| D | 0016763 | molecular_function | pentosyltransferase activity |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| E | 0005829 | cellular_component | cytosol |
| E | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| E | 0006152 | biological_process | purine nucleoside catabolic process |
| E | 0009116 | biological_process | nucleoside metabolic process |
| E | 0016763 | molecular_function | pentosyltransferase activity |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
| F | 0005829 | cellular_component | cytosol |
| F | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| F | 0006152 | biological_process | purine nucleoside catabolic process |
| F | 0009116 | biological_process | nucleoside metabolic process |
| F | 0016763 | molecular_function | pentosyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | binding site for residue FMC A 300 |
| Chain | Residue |
| A | MET64 |
| A | LEU206 |
| A | HOH420 |
| A | HOH450 |
| D | HIS4 |
| D | ARG43 |
| A | ARG87 |
| A | THR90 |
| A | CYS91 |
| A | GLY92 |
| A | PHE159 |
| A | GLU181 |
| A | SER203 |
| A | ASP204 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue FMC B 300 |
| Chain | Residue |
| B | ARG87 |
| B | THR90 |
| B | CYS91 |
| B | GLY92 |
| B | PHE159 |
| B | GLU179 |
| B | MET180 |
| B | GLU181 |
| B | SER203 |
| B | LEU206 |
| B | HOH408 |
| E | HIS4 |
| E | ARG43 |
| site_id | AC3 |
| Number of Residues | 13 |
| Details | binding site for residue FMC C 300 |
| Chain | Residue |
| C | MET64 |
| C | ARG87 |
| C | THR90 |
| C | CYS91 |
| C | GLY92 |
| C | PHE159 |
| C | GLU179 |
| C | MET180 |
| C | GLU181 |
| C | LEU206 |
| C | HOH422 |
| F | HIS4 |
| F | ARG43 |
| site_id | AC4 |
| Number of Residues | 13 |
| Details | binding site for residue FMC D 300 |
| Chain | Residue |
| A | HIS4 |
| A | ARG43 |
| D | MET64 |
| D | ARG87 |
| D | THR90 |
| D | CYS91 |
| D | GLY92 |
| D | PHE159 |
| D | GLU179 |
| D | GLU181 |
| D | SER203 |
| D | ASP204 |
| D | LEU206 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | binding site for residue FMC E 300 |
| Chain | Residue |
| B | HIS4 |
| B | ARG43 |
| E | ARG87 |
| E | THR90 |
| E | CYS91 |
| E | GLY92 |
| E | PHE159 |
| E | GLU179 |
| E | MET180 |
| E | GLU181 |
| E | SER203 |
| E | LEU206 |
| site_id | AC6 |
| Number of Residues | 16 |
| Details | binding site for residue FMC F 300 |
| Chain | Residue |
| C | HIS4 |
| C | ARG43 |
| F | MET64 |
| F | ARG87 |
| F | THR90 |
| F | CYS91 |
| F | GLY92 |
| F | PHE159 |
| F | MET180 |
| F | GLU181 |
| F | SER203 |
| F | ASP204 |
| F | LEU206 |
| F | HOH419 |
| F | HOH445 |
| F | HOH448 |
Functional Information from PROSITE/UniProt
| site_id | PS01232 |
| Number of Residues | 16 |
| Details | PNP_UDP_1 Purine and other phosphorylases family 1 signature. GhGMGiAScTIyvtEL |
| Chain | Residue | Details |
| A | GLY61-LEU76 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"HAMAP-Rule","id":"MF_01627","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P50389","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 48 |
| Details | Binding site: {"description":"in other chain","evidences":[{"source":"UniProtKB","id":"P50389","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Site: {"description":"Important for catalytic activity","evidences":[{"source":"HAMAP-Rule","id":"MF_01627","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
