Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6F23

Complex between MTH1 and compound 16 (a 4-amino-7-azaindole derivative)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001669	cellular_component	acrosomal vesicle
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005829	cellular_component	cytosol
A	0006152	biological_process	purine nucleoside catabolic process
A	0006281	biological_process	DNA repair
A	0006979	biological_process	response to oxidative stress
A	0008413	molecular_function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
A	0008584	biological_process	male gonad development
A	0008828	molecular_function	dATP diphosphatase activity
A	0016787	molecular_function	hydrolase activity
A	0016818	molecular_function	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
A	0030515	molecular_function	snoRNA binding
A	0031965	cellular_component	nuclear membrane
A	0035539	molecular_function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
A	0042262	biological_process	DNA protection
A	0046686	biological_process	response to cadmium ion
A	0046872	molecular_function	metal ion binding
A	0047693	molecular_function	ATP diphosphatase activity
A	0106377	molecular_function	2-hydroxy-ATP hydrolase activity
A	0106378	molecular_function	2-hydroxy-dATP hydrolase activity
A	0106431	molecular_function	N6-methyl-(d)ATP hydrolase activity
A	0106433	molecular_function	O6-methyl-dGTP hydrolase activity
A	0140933	molecular_function	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity
B	0001669	cellular_component	acrosomal vesicle
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0005829	cellular_component	cytosol
B	0006152	biological_process	purine nucleoside catabolic process
B	0006281	biological_process	DNA repair
B	0006979	biological_process	response to oxidative stress
B	0008413	molecular_function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
B	0008584	biological_process	male gonad development
B	0008828	molecular_function	dATP diphosphatase activity
B	0016787	molecular_function	hydrolase activity
B	0016818	molecular_function	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
B	0030515	molecular_function	snoRNA binding
B	0031965	cellular_component	nuclear membrane
B	0035539	molecular_function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
B	0042262	biological_process	DNA protection
B	0046686	biological_process	response to cadmium ion
B	0046872	molecular_function	metal ion binding
B	0047693	molecular_function	ATP diphosphatase activity
B	0106377	molecular_function	2-hydroxy-ATP hydrolase activity
B	0106378	molecular_function	2-hydroxy-dATP hydrolase activity
B	0106431	molecular_function	N6-methyl-(d)ATP hydrolase activity
B	0106433	molecular_function	O6-methyl-dGTP hydrolase activity
B	0140933	molecular_function	5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue C8Z A 201

Chain	Residue
A	THR8
A	LEU9
A	PHE27
A	PHE72
A	TRP117
A	ASP119
A	ASP120

site_id	AC2
Number of Residues	7
Details	binding site for residue SO4 A 202

Chain	Residue
A	ASP154
A	THR155
A	HOH330
B	VAL96
B	GLU97
A	ARG151
A	VAL153

site_id	AC3
Number of Residues	4
Details	binding site for residue SO4 A 203

Chain	Residue
A	GLY-2
A	HIS134
A	ARG151
B	THR94

site_id	AC4
Number of Residues	6
Details	binding site for residue SO4 A 204

Chain	Residue
A	ALA63
A	HIS65
A	THR88
A	ASP89
A	SER90
A	HOH312

site_id	AC5
Number of Residues	3
Details	binding site for residue SO4 A 205

Chain	Residue
A	HIS65
A	LYS66
A	HOH348

site_id	AC6
Number of Residues	5
Details	binding site for residue SO4 A 206

Chain	Residue
A	ARG17
A	THR94
A	PRO95
A	TRP105
B	LYS132

site_id	AC7
Number of Residues	5
Details	binding site for residue GOL A 207

Chain	Residue
A	THR44
A	ILE45
A	GLU46
A	HOH371
B	GLY42

site_id	AC8
Number of Residues	12
Details	binding site for residue GOL A 208

Chain	Residue
A	LYS24
A	GLU97
A	SER98
A	ASP99
A	LYS138
A	ASP147
A	HOH310
A	HOH364
B	TYR122
B	ILE145
B	LEU146
B	SO4203

site_id	AC9
Number of Residues	7
Details	binding site for residue C8Z B 200

Chain	Residue
B	THR8
B	PHE27
B	PHE72
B	MET81
B	TRP117
B	ASP119
B	ASP120

site_id	AD1
Number of Residues	7
Details	binding site for residue SO4 B 201

Chain	Residue
B	ARG151
B	VAL153
B	ASP154
B	THR155
B	HOH302
B	HOH310
B	HOH357

site_id	AD2
Number of Residues	5
Details	binding site for residue SO4 B 202

Chain	Residue
B	ALA63
B	HIS65
B	THR88
B	ASP89
B	SER90

site_id	AD3
Number of Residues	6
Details	binding site for residue SO4 B 203

Chain	Residue
A	LYS24
A	GOL208
A	HOH306
B	TYR122
B	TYR148
B	HOH308

site_id	AD4
Number of Residues	4
Details	binding site for residue SO4 B 204

Chain	Residue
A	TYR148
B	HIS134
B	ARG151
B	HOH322

site_id	AD5
Number of Residues	3
Details	binding site for residue SO4 B 205

Chain	Residue
B	LEU64
B	HIS65
B	LYS66

site_id	AD6
Number of Residues	6
Details	binding site for residue SO4 B 206

Chain	Residue
A	GLN16
A	GLY42
B	THR44
B	ILE45
B	GLU46
B	HOH358

Functional Information from PROSITE/UniProt

site_id	PS00893
Number of Residues	22
Details	NUDIX_BOX Nudix box signature. GkvqegEtiedGArRELqEEsG

Chain	Residue	Details
A	GLY37-GLY58

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:Q7ZWC3

Chain	Residue	Details
A	LEU11
A	GLN14
A	PRO15
A	LEU59
B	LEU11
B	GLN14
B	PRO15
B	LEU59

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269\|PubMed:30304478, ECO:0007744\|PDB:5OTM

Chain	Residue	Details
A	GLY76
B	GLY76

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)