6EZP
CATHEPSIN L IN COMPLEX WITH (3S,14E)-19-chloro-N-(1-cyanocyclopropyl)-5-oxo-12,17-dioxa-4-azatricyclo[16.2.2.06,11]docosa-1(21),6(11),7,9,14,18(22),19-heptaene-3-carboxamide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006508 | biological_process | proteolysis |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | binding site for residue C3E A 301 |
| Chain | Residue |
| A | ARG8 |
| A | GLY68 |
| A | LEU69 |
| A | MET70 |
| A | ALA135 |
| A | MET161 |
| A | ASP162 |
| A | ALA214 |
| A | HOH486 |
| A | HOH571 |
| A | GLU9 |
| A | GLN19 |
| A | GLY23 |
| A | SER24 |
| A | CYS25 |
| A | TRP26 |
| A | ASN66 |
| A | GLY67 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 302 |
| Chain | Residue |
| A | ASN18 |
| A | GLN19 |
| A | GLY20 |
| A | TRP189 |
| A | HOH417 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | binding site for residue GOL A 303 |
Functional Information from PROSITE/UniProt
| site_id | PS00139 |
| Number of Residues | 12 |
| Details | THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGqCGSCWAfSA |
| Chain | Residue | Details |
| A | GLN19-ALA30 | |
| site_id | PS00639 |
| Number of Residues | 11 |
| Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. MDHGVLVVGYG |
| Chain | Residue | Details |
| A | MET161-GLY171 | |
| site_id | PS00640 |
| Number of Residues | 20 |
| Details | THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWLvKNSWgeeWGmgGYVkM |
| Chain | Residue | Details |
| A | TYR182-MET201 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | CYS25 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: |
| Chain | Residue | Details |
| A | HIS163 | |
| A | ASN187 | |
| Chain | Residue | Details |
| A | ASN108 | |
