Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6EYP

X-ray structure of the unliganded uridine phosphorylase from Vibrio cholerae at 1.22A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004731	molecular_function	purine-nucleoside phosphorylase activity
A	0004850	molecular_function	uridine phosphorylase activity
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006152	biological_process	purine nucleoside catabolic process
A	0006218	biological_process	uridine catabolic process
A	0009116	biological_process	nucleoside metabolic process
A	0009164	biological_process	nucleoside catabolic process
A	0009166	biological_process	nucleotide catabolic process
A	0016757	molecular_function	glycosyltransferase activity
A	0016763	molecular_function	pentosyltransferase activity
A	0044206	biological_process	UMP salvage
A	0046872	molecular_function	metal ion binding
B	0003824	molecular_function	catalytic activity
B	0004731	molecular_function	purine-nucleoside phosphorylase activity
B	0004850	molecular_function	uridine phosphorylase activity
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006152	biological_process	purine nucleoside catabolic process
B	0006218	biological_process	uridine catabolic process
B	0009116	biological_process	nucleoside metabolic process
B	0009164	biological_process	nucleoside catabolic process
B	0009166	biological_process	nucleotide catabolic process
B	0016757	molecular_function	glycosyltransferase activity
B	0016763	molecular_function	pentosyltransferase activity
B	0044206	biological_process	UMP salvage
B	0046872	molecular_function	metal ion binding
C	0003824	molecular_function	catalytic activity
C	0004731	molecular_function	purine-nucleoside phosphorylase activity
C	0004850	molecular_function	uridine phosphorylase activity
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006152	biological_process	purine nucleoside catabolic process
C	0006218	biological_process	uridine catabolic process
C	0009116	biological_process	nucleoside metabolic process
C	0009164	biological_process	nucleoside catabolic process
C	0009166	biological_process	nucleotide catabolic process
C	0016757	molecular_function	glycosyltransferase activity
C	0016763	molecular_function	pentosyltransferase activity
C	0044206	biological_process	UMP salvage
C	0046872	molecular_function	metal ion binding
D	0003824	molecular_function	catalytic activity
D	0004731	molecular_function	purine-nucleoside phosphorylase activity
D	0004850	molecular_function	uridine phosphorylase activity
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006152	biological_process	purine nucleoside catabolic process
D	0006218	biological_process	uridine catabolic process
D	0009116	biological_process	nucleoside metabolic process
D	0009164	biological_process	nucleoside catabolic process
D	0009166	biological_process	nucleotide catabolic process
D	0016757	molecular_function	glycosyltransferase activity
D	0016763	molecular_function	pentosyltransferase activity
D	0044206	biological_process	UMP salvage
D	0046872	molecular_function	metal ion binding
E	0003824	molecular_function	catalytic activity
E	0004731	molecular_function	purine-nucleoside phosphorylase activity
E	0004850	molecular_function	uridine phosphorylase activity
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006152	biological_process	purine nucleoside catabolic process
E	0006218	biological_process	uridine catabolic process
E	0009116	biological_process	nucleoside metabolic process
E	0009164	biological_process	nucleoside catabolic process
E	0009166	biological_process	nucleotide catabolic process
E	0016757	molecular_function	glycosyltransferase activity
E	0016763	molecular_function	pentosyltransferase activity
E	0044206	biological_process	UMP salvage
E	0046872	molecular_function	metal ion binding
F	0003824	molecular_function	catalytic activity
F	0004731	molecular_function	purine-nucleoside phosphorylase activity
F	0004850	molecular_function	uridine phosphorylase activity
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006152	biological_process	purine nucleoside catabolic process
F	0006218	biological_process	uridine catabolic process
F	0009116	biological_process	nucleoside metabolic process
F	0009164	biological_process	nucleoside catabolic process
F	0009166	biological_process	nucleotide catabolic process
F	0016757	molecular_function	glycosyltransferase activity
F	0016763	molecular_function	pentosyltransferase activity
F	0044206	biological_process	UMP salvage
F	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue GOL A 301

Chain	Residue
A	ILE68
A	GLU195
A	MET196
A	GLU197
A	HOH533
A	HOH542
B	HIS7
B	ARG47

site_id	AC2
Number of Residues	6
Details	binding site for residue NA A 302

Chain	Residue
A	ILE68
A	SER72
B	GLU48
B	ILE68
B	SER72
A	GLU48

site_id	AC3
Number of Residues	8
Details	binding site for residue GOL B 301

Chain	Residue
A	HIS7
A	HOH549
B	PHE161
B	GLU195
B	MET196
B	GLU197
B	HOH478
B	HOH486

site_id	AC4
Number of Residues	9
Details	binding site for residue GOL C 301

Chain	Residue
C	ILE68
C	PHE161
C	GLU195
C	MET196
C	GLU197
C	HOH491
C	HOH602
C	HOH612
D	HIS7

site_id	AC5
Number of Residues	6
Details	binding site for residue NA C 302

Chain	Residue
C	GLU48
C	ILE68
C	SER72
D	GLU48
D	ILE68
D	SER72

site_id	AC6
Number of Residues	6
Details	binding site for residue MG C 303

Chain	Residue
C	ASN102
C	HOH427
C	HOH516
C	HOH585
C	HOH603
C	HOH647

site_id	AC7
Number of Residues	8
Details	binding site for residue GOL D 301

Chain	Residue
C	HIS7
D	ILE68
D	GLU195
D	MET196
D	GLU197
D	HOH421
D	HOH446
D	HOH487

site_id	AC8
Number of Residues	11
Details	binding site for residue GOL D 302

Chain	Residue
D	LEU115
D	ARG178
D	PHE179
D	SER182
D	GLU185
D	HOH402
D	HOH413
D	HOH416
E	PRO124
E	GLU126
F	ARG177

site_id	AC9
Number of Residues	8
Details	binding site for residue GOL E 301

Chain	Residue
E	ILE68
E	GLU195
E	MET196
E	GLU197
E	HOH420
E	HOH484
F	HIS7
F	ARG47

site_id	AD1
Number of Residues	6
Details	binding site for residue NA E 302

Chain	Residue
E	GLU48
E	ILE68
E	SER72
F	GLU48
F	ILE68
F	SER72

site_id	AD2
Number of Residues	10
Details	binding site for residue GOL F 301

Chain	Residue
E	HIS7
E	ARG47
F	ILE68
F	GLU195
F	MET196
F	GLU197
F	HOH464
F	HOH558
F	HOH564
F	HOH584

site_id	AD3
Number of Residues	10
Details	binding site for residue GOL F 302

Chain	Residue
A	PRO124
A	GLU126
B	ARG177
B	HOH401
F	LEU115
F	ARG178
F	GLU185
F	HOH409
F	HOH443
F	HOH602

Functional Information from PROSITE/UniProt

site_id	PS01232
Number of Residues	16
Details	PNP_UDP_1 Purine and other phosphorylases family 1 signature. StGIGgPStSIaveEL

Chain	Residue	Details
A	SER65-LEU80

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)