6EW5

Human myelin protein P2 F57A mutant, monoclinic crystal form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005504	molecular_function	fatty acid binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0008289	molecular_function	lipid binding
A	0015485	molecular_function	cholesterol binding
A	0015908	biological_process	fatty acid transport
A	0043209	cellular_component	myelin sheath
A	0061024	biological_process	membrane organization
A	0070062	cellular_component	extracellular exosome
B	0005504	molecular_function	fatty acid binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0008289	molecular_function	lipid binding
B	0015485	molecular_function	cholesterol binding
B	0015908	biological_process	fatty acid transport
B	0043209	cellular_component	myelin sheath
B	0061024	biological_process	membrane organization
B	0070062	cellular_component	extracellular exosome
C	0005504	molecular_function	fatty acid binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0008289	molecular_function	lipid binding
C	0015485	molecular_function	cholesterol binding
C	0015908	biological_process	fatty acid transport
C	0043209	cellular_component	myelin sheath
C	0061024	biological_process	membrane organization
C	0070062	cellular_component	extracellular exosome
D	0005504	molecular_function	fatty acid binding
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0008289	molecular_function	lipid binding
D	0015485	molecular_function	cholesterol binding
D	0015908	biological_process	fatty acid transport
D	0043209	cellular_component	myelin sheath
D	0061024	biological_process	membrane organization
D	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue PLM A 201

Chain	Residue
A	THR29
A	LEU32
A	SER55
A	ASP76
A	ARG106
A	ARG126
A	TYR128
A	HOH306
A	HOH353

---

site_id	AC2
Number of Residues	12
Details	binding site for residue PLM B 201

Chain	Residue
B	PHE16
B	MET20
B	THR29
B	LEU32
B	LYS58
B	ASP76
B	ILE104
B	ARG106
B	ARG126
B	TYR128
B	HOH319
B	HOH349

---

site_id	AC3
Number of Residues	11
Details	binding site for residue PLM C 201

Chain	Residue
C	MET20
C	THR29
C	LEU32
C	THR53
C	LYS58
C	ARG106
C	CYS117
C	ARG126
C	TYR128
C	HOH320
C	HOH334

---

site_id	AC4
Number of Residues	11
Details	binding site for residue PLM D 201

Chain	Residue
D	TYR19
D	MET20
D	THR29
D	LEU32
D	GLY33
D	ARG78
D	ARG106
D	ARG126
D	TYR128
D	HOH328
D	HOH355

---

Functional Information from PROSITE/UniProt

site_id	PS00214
Number of Residues	18
Details	FABP Cytosolic fatty-acid binding proteins signature. GTWkLvsSeNFDdYMKAL

Chain	Residue	Details
A	GLY6-LEU23

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:20421974, ECO:0007744|PDB:2WUT

Chain	Residue	Details
A	ARG106
A	ARG126
B	ARG106
B	ARG126
C	ARG106
C	ARG126
D	ARG106
D	ARG126

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: N-acetylserine => ECO:0000269|PubMed:6183401

Chain	Residue	Details
A	SER1
B	SER1
C	SER1
D	SER1

---