6ETG

Crystal structure of KDM4D with tetrazolhydrazide compound 6

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 401

Chain	Residue
A	CYS238
A	HIS244
A	CYS310
A	CYS312

---

site_id	AC2
Number of Residues	7
Details	binding site for residue NI A 402

Chain	Residue
A	HOH620
A	HOH689
A	HIS192
A	GLU194
A	HIS280
A	BWT415
A	HOH599

---

site_id	AC3
Number of Residues	5
Details	binding site for residue EDO A 403

Chain	Residue
A	ARG123
A	LYS124
A	LYS127
A	ASN128
A	HOH564

---

site_id	AC4
Number of Residues	8
Details	binding site for residue EDO A 404

Chain	Residue
A	LYS150
A	GLN151
A	TRP152
A	ASN153
A	HIS156
A	HOH527
A	HOH641
A	HOH734

---

site_id	AC5
Number of Residues	5
Details	binding site for residue EDO A 405

Chain	Residue
A	PRO251
A	THR252
A	LYS255
A	ARG263
A	HOH513

---

site_id	AC6
Number of Residues	5
Details	binding site for residue EDO A 406

Chain	Residue
A	PHE118
A	ARG263
A	ILE264
A	THR265
A	HOH725

---

site_id	AC7
Number of Residues	6
Details	binding site for residue EDO A 407

Chain	Residue
A	LYS109
A	GLN111
A	ASN132
A	TRP185
A	LYS186
A	HOH519

---

site_id	AC8
Number of Residues	7
Details	binding site for residue EDO A 408

Chain	Residue
A	PHE31
A	ASP32
A	GLY158
A	PHE295
A	ALA296
A	HOH520
A	HOH723

---

site_id	AC9
Number of Residues	6
Details	binding site for residue EDO A 409

Chain	Residue
A	TYR181
A	GLU194
A	SER200
A	ALA292
A	ASN294
A	BWT415

---

site_id	AD1
Number of Residues	3
Details	binding site for residue EDO A 410

Chain	Residue
A	GLU56
A	TRP57
A	GLN151

---

site_id	AD2
Number of Residues	5
Details	binding site for residue EDO A 411

Chain	Residue
A	ASN176
A	ASP195
A	ASN294
A	SER320
A	HOH623

---

site_id	AD3
Number of Residues	8
Details	binding site for residue SO4 A 412

Chain	Residue
A	ARG60
A	GLU61
A	THR62
A	ASN65
A	HOH510
A	HOH514
A	HOH571
A	HOH824

---

site_id	AD4
Number of Residues	6
Details	binding site for residue SO4 A 413

Chain	Residue
A	ARG102
A	HIS103
A	ASN106
A	HOH572
A	HOH858
A	HOH874

---

site_id	AD5
Number of Residues	10
Details	binding site for residue SO4 A 414

Chain	Residue
A	MET19
A	ILE20
A	LYS255
A	HOH591
A	HOH632
A	HOH716
A	HOH872
A	HOH904
A	HOH908
A	HOH961

---

site_id	AD6
Number of Residues	17
Details	binding site for residue BWT A 415

Chain	Residue
A	HOH620
A	HOH682
A	HOH689
A	TYR136
A	THR187
A	THR188
A	PHE189
A	HIS192
A	GLU194
A	HIS280
A	ASN284
A	NI402
A	EDO409
A	HOH517
A	HOH559
A	HOH599
A	HOH612

---

site_id	AD7
Number of Residues	6
Details	binding site for residue NA A 416

Chain	Residue
A	ASN17
A	ASN262
A	HOH568
A	HOH686
A	HOH847
A	HOH847

---

site_id	AD8
Number of Residues	2
Details	binding site for residue CL A 417

Chain	Residue
A	ASN128
A	LYS186

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	42
Details	Domain: {"description":"JmjN","evidences":[{"source":"PROSITE-ProRule","id":"PRU00537","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	166
Details	Domain: {"description":"JmjC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"B2RXH2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00538","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26741168","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PDB","id":"5F5A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5F5C","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"PolyADP-ribosyl glutamic acid","evidences":[{"source":"PubMed","id":"23102699","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---