6EPL

Ras guanine exchange factor SOS1 (Rem-cdc25) in complex with KRAS(G12C)

Functional Information from GO Data

Chain	GOid	namespace	contents
R	0003924	molecular_function	GTPase activity
R	0005525	molecular_function	GTP binding
R	0007165	biological_process	signal transduction
R	0016020	cellular_component	membrane
S	0005085	molecular_function	guanyl-nucleotide exchange factor activity
S	0007264	biological_process	small GTPase-mediated signal transduction

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue GOL R 201

Chain	Residue
R	THR35
R	HOH358

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Functional Information from PROSITE/UniProt

site_id	PS00720
Number of Residues	34
Details	RASGEF Ras Guanine-nucleotide exchange factors domain signature. VPFfGiyLtNIlkteegnpevlkrhgkel.................INFsK

Chain	Residue	Details
S	VAL927-LYS960

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:22431598, ECO:0000269|PubMed:22566140

Chain	Residue	Details
R	GLY10
R	VAL29
R	ALA59
R	ASN116

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N-acetylmethionine; in GTPase KRas; alternate => ECO:0000269|Ref.17

Chain	Residue	Details
R	MET1

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N-acetylthreonine; in GTPase KRas, N-terminally processed => ECO:0000269|Ref.17

Chain	Residue	Details
R	THR2

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:22711838

Chain	Residue	Details
R	LYS104

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site_id	SWS_FT_FI5
Number of Residues	1
Details	CARBOHYD: (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486

Chain	Residue	Details
R	THR35

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