6EO1

The electron crystallography structure of the cAMP-bound potassium channel MloK1 (PCO-refined)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005216	molecular_function	monoatomic ion channel activity
A	0005221	molecular_function	intracellularly cyclic nucleotide-activated monoatomic cation channel activity
A	0005267	molecular_function	potassium channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0016020	cellular_component	membrane
A	0030552	molecular_function	cAMP binding
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0044877	molecular_function	protein-containing complex binding
A	0055085	biological_process	transmembrane transport
A	0071805	biological_process	potassium ion transmembrane transport
B	0000166	molecular_function	nucleotide binding
B	0005216	molecular_function	monoatomic ion channel activity
B	0005221	molecular_function	intracellularly cyclic nucleotide-activated monoatomic cation channel activity
B	0005267	molecular_function	potassium channel activity
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006813	biological_process	potassium ion transport
B	0016020	cellular_component	membrane
B	0030552	molecular_function	cAMP binding
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0044877	molecular_function	protein-containing complex binding
B	0055085	biological_process	transmembrane transport
B	0071805	biological_process	potassium ion transmembrane transport
C	0000166	molecular_function	nucleotide binding
C	0005216	molecular_function	monoatomic ion channel activity
C	0005221	molecular_function	intracellularly cyclic nucleotide-activated monoatomic cation channel activity
C	0005267	molecular_function	potassium channel activity
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006813	biological_process	potassium ion transport
C	0016020	cellular_component	membrane
C	0030552	molecular_function	cAMP binding
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0042802	molecular_function	identical protein binding
C	0044877	molecular_function	protein-containing complex binding
C	0055085	biological_process	transmembrane transport
C	0071805	biological_process	potassium ion transmembrane transport
D	0000166	molecular_function	nucleotide binding
D	0005216	molecular_function	monoatomic ion channel activity
D	0005221	molecular_function	intracellularly cyclic nucleotide-activated monoatomic cation channel activity
D	0005267	molecular_function	potassium channel activity
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006813	biological_process	potassium ion transport
D	0016020	cellular_component	membrane
D	0030552	molecular_function	cAMP binding
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0042802	molecular_function	identical protein binding
D	0044877	molecular_function	protein-containing complex binding
D	0055085	biological_process	transmembrane transport
D	0071805	biological_process	potassium ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue K C 401

Chain	Residue
A	GLY177
A	TYR178
B	GLY177
B	TYR178
C	GLY177
C	TYR178
D	GLY177
D	TYR178

---

site_id	AC2
Number of Residues	8
Details	binding site for residue K C 402

Chain	Residue
A	THR176
B	THR175
B	THR176
C	THR175
C	THR176
D	THR175
D	THR176
A	THR175

---

Functional Information from PROSITE/UniProt

site_id	PS00888
Number of Residues	17
Details	CNMP_BINDING_1 Cyclic nucleotide-binding domain signature 1. ICrIGEpGDrMFFVveG

Chain	Residue	Details
A	ILE262-GLY278

---

site_id	PS00889
Number of Residues	18
Details	CNMP_BINDING_2 Cyclic nucleotide-binding domain signature 2. FGEmALisgep......RSAtVsA

Chain	Residue	Details
A	PHE296-ALA313

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	732
Details	Topological domain: {"description":"Cytoplasmic"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	68
Details	Transmembrane: {"description":"Helical; Name=Segment S1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	84
Details	Topological domain: {"description":"Periplasmic"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	88
Details	Transmembrane: {"description":"Helical; Name=Segment S2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	76
Details	Transmembrane: {"description":"Helical; Name=Segment S3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	68
Details	Transmembrane: {"description":"Helical; Name=Segment S4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	80
Details	Transmembrane: {"description":"Helical; Name=Segment S5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	72
Details	Intramembrane: {"description":"Pore-forming"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	96
Details	Transmembrane: {"description":"Helical; Name=Segment S6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	20
Details	Motif: {"description":"Selectivity filter","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PDB","id":"1VP6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---