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6ENY

Structure of the human PLC editing module

Functional Information from GO Data
ChainGOidnamespacecontents
B0000139cellular_componentGolgi membrane
B0001913biological_processT cell mediated cytotoxicity
B0001916biological_processpositive regulation of T cell mediated cytotoxicity
B0002237biological_processresponse to molecule of bacterial origin
B0002376biological_processimmune system process
B0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
B0002481biological_processantigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B0002502biological_processpeptide antigen assembly with MHC class I protein complex
B0002503biological_processpeptide antigen assembly with MHC class II protein complex
B0002726biological_processpositive regulation of T cell cytokine production
B0005198molecular_functionstructural molecule activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005765cellular_componentlysosomal membrane
B0005783cellular_componentendoplasmic reticulum
B0005788cellular_componentendoplasmic reticulum lumen
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0006826biological_processiron ion transport
B0006879biological_processintracellular iron ion homeostasis
B0006955biological_processimmune response
B0007608biological_processsensory perception of smell
B0007611biological_processlearning or memory
B0009897cellular_componentexternal side of plasma membrane
B0009986cellular_componentcell surface
B0010977biological_processnegative regulation of neuron projection development
B0012507cellular_componentER to Golgi transport vesicle membrane
B0016020cellular_componentmembrane
B0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
B0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
B0023026molecular_functionMHC class II protein complex binding
B0030670cellular_componentphagocytic vesicle membrane
B0031901cellular_componentearly endosome membrane
B0031902cellular_componentlate endosome membrane
B0031905cellular_componentearly endosome lumen
B0032092biological_processpositive regulation of protein binding
B0033077biological_processT cell differentiation in thymus
B0034756biological_processregulation of iron ion transport
B0035580cellular_componentspecific granule lumen
B0042026biological_processprotein refolding
B0042605molecular_functionpeptide antigen binding
B0042612cellular_componentMHC class I protein complex
B0042613cellular_componentMHC class II protein complex
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0042824cellular_componentMHC class I peptide loading complex
B0045646biological_processregulation of erythrocyte differentiation
B0048260biological_processpositive regulation of receptor-mediated endocytosis
B0050680biological_processnegative regulation of epithelial cell proliferation
B0050768biological_processnegative regulation of neurogenesis
B0050778biological_processpositive regulation of immune response
B0050870biological_processpositive regulation of T cell activation
B0051289biological_processprotein homotetramerization
B0055038cellular_componentrecycling endosome membrane
B0060586biological_processmulticellular organismal-level iron ion homeostasis
B0070062cellular_componentextracellular exosome
B0071281biological_processcellular response to iron ion
B0071283biological_processcellular response to iron(III) ion
B0071316biological_processcellular response to nicotine
B1900121biological_processnegative regulation of receptor binding
B1900122biological_processpositive regulation of receptor binding
B1904434biological_processpositive regulation of ferrous iron binding
B1904437biological_processpositive regulation of transferrin receptor binding
B1904724cellular_componenttertiary granule lumen
B1990000biological_processamyloid fibril formation
B1990712cellular_componentHFE-transferrin receptor complex
B2000774biological_processpositive regulation of cellular senescence
B2000978biological_processnegative regulation of forebrain neuron differentiation
C0000139cellular_componentGolgi membrane
C0002397biological_processMHC class I protein complex assembly
C0002398biological_processMHC class Ib protein complex assembly
C0002502biological_processpeptide antigen assembly with MHC class I protein complex
C0005515molecular_functionprotein binding
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0006457biological_processprotein folding
C0006890biological_processretrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
C0010468biological_processregulation of gene expression
C0016020cellular_componentmembrane
C0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
C0023024molecular_functionMHC class I protein complex binding
C0030670cellular_componentphagocytic vesicle membrane
C0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
C0042288molecular_functionMHC class I protein binding
C0042605molecular_functionpeptide antigen binding
C0042824cellular_componentMHC class I peptide loading complex
C0044183molecular_functionprotein folding chaperone
C0046978molecular_functionTAP1 binding
C0046979molecular_functionTAP2 binding
C0050823biological_processpeptide antigen stabilization
C0051082molecular_functionunfolded protein binding
C0060090molecular_functionmolecular adaptor activity
C0061635biological_processregulation of protein complex stability
C0061779cellular_componentTapasin-ERp57 complex
C0062061molecular_functionTAP complex binding
C0065003biological_processprotein-containing complex assembly
C0098553cellular_componentlumenal side of endoplasmic reticulum membrane
D0002250biological_processadaptive immune response
D0002376biological_processimmune system process
D0002502biological_processpeptide antigen assembly with MHC class I protein complex
D0003723molecular_functionRNA binding
D0003756molecular_functionprotein disulfide isomerase activity
D0004197molecular_functioncysteine-type endopeptidase activity
D0004629molecular_functionphospholipase C activity
D0005515molecular_functionprotein binding
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005783cellular_componentendoplasmic reticulum
D0005788cellular_componentendoplasmic reticulum lumen
D0005925cellular_componentfocal adhesion
D0006457biological_processprotein folding
D0009986cellular_componentcell surface
D0015035molecular_functionprotein-disulfide reductase activity
D0015036molecular_functiondisulfide oxidoreductase activity
D0016853molecular_functionisomerase activity
D0034975biological_processprotein folding in endoplasmic reticulum
D0034976biological_processresponse to endoplasmic reticulum stress
D0042470cellular_componentmelanosome
D0042802molecular_functionidentical protein binding
D0042824cellular_componentMHC class I peptide loading complex
D0045335cellular_componentphagocytic vesicle
D0055038cellular_componentrecycling endosome membrane
D0061779cellular_componentTapasin-ERp57 complex
D0070062cellular_componentextracellular exosome
D0070527biological_processplatelet aggregation
D0097191biological_processextrinsic apoptotic signaling pathway
D0098761biological_processcellular response to interleukin-7
D2001238biological_processpositive regulation of extrinsic apoptotic signaling pathway
F0000139cellular_componentGolgi membrane
F0001913biological_processT cell mediated cytotoxicity
F0001916biological_processpositive regulation of T cell mediated cytotoxicity
F0002250biological_processadaptive immune response
F0002376biological_processimmune system process
F0002419biological_processT cell mediated cytotoxicity directed against tumor cell target
F0002474biological_processantigen processing and presentation of peptide antigen via MHC class I
F0002476biological_processantigen processing and presentation of endogenous peptide antigen via MHC class Ib
F0002485biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent
F0002486biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent
F0002502biological_processpeptide antigen assembly with MHC class I protein complex
F0002726biological_processpositive regulation of T cell cytokine production
F0003723molecular_functionRNA binding
F0005102molecular_functionsignaling receptor binding
F0005515molecular_functionprotein binding
F0005615cellular_componentextracellular space
F0005783cellular_componentendoplasmic reticulum
F0005789cellular_componentendoplasmic reticulum membrane
F0005794cellular_componentGolgi apparatus
F0005797cellular_componentGolgi medial cisterna
F0005886cellular_componentplasma membrane
F0006955biological_processimmune response
F0009897cellular_componentexternal side of plasma membrane
F0009986cellular_componentcell surface
F0012507cellular_componentER to Golgi transport vesicle membrane
F0016020cellular_componentmembrane
F0016045biological_processdetection of bacterium
F0019731biological_processantibacterial humoral response
F0019882biological_processantigen processing and presentation
F0019885biological_processantigen processing and presentation of endogenous peptide antigen via MHC class I
F0030670cellular_componentphagocytic vesicle membrane
F0030881molecular_functionbeta-2-microglobulin binding
F0031901cellular_componentearly endosome membrane
F0032729biological_processpositive regulation of type II interferon production
F0036037biological_processCD8-positive, alpha-beta T cell activation
F0042270biological_processprotection from natural killer cell mediated cytotoxicity
F0042590biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I
F0042605molecular_functionpeptide antigen binding
F0042608molecular_functionT cell receptor binding
F0042610molecular_functionCD8 receptor binding
F0042612cellular_componentMHC class I protein complex
F0042824cellular_componentMHC class I peptide loading complex
F0045087biological_processinnate immune response
F0046977molecular_functionTAP binding
F0050830biological_processdefense response to Gram-positive bacterium
F0050852biological_processT cell receptor signaling pathway
F0055038cellular_componentrecycling endosome membrane
F0062061molecular_functionTAP complex binding
F0070062cellular_componentextracellular exosome
F0070971cellular_componentendoplasmic reticulum exit site
F0098553cellular_componentlumenal side of endoplasmic reticulum membrane
F2000566biological_processpositive regulation of CD8-positive, alpha-beta T cell proliferation
F2000568biological_processpositive regulation of memory T cell activation
F2001187biological_processpositive regulation of CD8-positive, alpha-beta T cell activation
G0000122biological_processnegative regulation of transcription by RNA polymerase II
G0001669cellular_componentacrosomal vesicle
G0001849molecular_functioncomplement component C1q complex binding
G0002502biological_processpeptide antigen assembly with MHC class I protein complex
G0003677molecular_functionDNA binding
G0003723molecular_functionRNA binding
G0003729molecular_functionmRNA binding
G0005049molecular_functionnuclear export signal receptor activity
G0005178molecular_functionintegrin binding
G0005506molecular_functioniron ion binding
G0005509molecular_functioncalcium ion binding
G0005515molecular_functionprotein binding
G0005576cellular_componentextracellular region
G0005615cellular_componentextracellular space
G0005634cellular_componentnucleus
G0005635cellular_componentnuclear envelope
G0005737cellular_componentcytoplasm
G0005764cellular_componentlysosome
G0005783cellular_componentendoplasmic reticulum
G0005788cellular_componentendoplasmic reticulum lumen
G0005789cellular_componentendoplasmic reticulum membrane
G0005790cellular_componentsmooth endoplasmic reticulum
G0005829cellular_componentcytosol
G0005840cellular_componentribosome
G0005925cellular_componentfocal adhesion
G0006355biological_processregulation of DNA-templated transcription
G0006457biological_processprotein folding
G0006611biological_processprotein export from nucleus
G0006874biological_processintracellular calcium ion homeostasis
G0007283biological_processspermatogenesis
G0008270molecular_functionzinc ion binding
G0008284biological_processpositive regulation of cell population proliferation
G0009410biological_processresponse to xenobiotic stimulus
G0009897cellular_componentexternal side of plasma membrane
G0009986cellular_componentcell surface
G0010033biological_processresponse to organic substance
G0010595biological_processpositive regulation of endothelial cell migration
G0010628biological_processpositive regulation of gene expression
G0012505cellular_componentendomembrane system
G0016020cellular_componentmembrane
G0016529cellular_componentsarcoplasmic reticulum
G0017148biological_processnegative regulation of translation
G0022417biological_processprotein maturation by protein folding
G0030246molecular_functioncarbohydrate binding
G0030670cellular_componentphagocytic vesicle membrane
G0030866biological_processcortical actin cytoskeleton organization
G0031410cellular_componentcytoplasmic vesicle
G0031625molecular_functionubiquitin protein ligase binding
G0032355biological_processresponse to estradiol
G0032991cellular_componentprotein-containing complex
G0033018cellular_componentsarcoplasmic reticulum lumen
G0033116cellular_componentendoplasmic reticulum-Golgi intermediate compartment membrane
G0033144biological_processnegative regulation of intracellular steroid hormone receptor signaling pathway
G0033574biological_processresponse to testosterone
G0034504biological_processprotein localization to nucleus
G0034975biological_processprotein folding in endoplasmic reticulum
G0036503biological_processERAD pathway
G0040020biological_processregulation of meiotic nuclear division
G0042277molecular_functionpeptide binding
G0042562molecular_functionhormone binding
G0042824cellular_componentMHC class I peptide loading complex
G0042921biological_processintracellular glucocorticoid receptor signaling pathway
G0042981biological_processregulation of apoptotic process
G0043231cellular_componentintracellular membrane-bounded organelle
G0044183molecular_functionprotein folding chaperone
G0044194cellular_componentcytolytic granule
G0044322cellular_componentendoplasmic reticulum quality control compartment
G0045665biological_processnegative regulation of neuron differentiation
G0045787biological_processpositive regulation of cell cycle
G0045892biological_processnegative regulation of DNA-templated transcription
G0046872molecular_functionmetal ion binding
G0048387biological_processnegative regulation of retinoic acid receptor signaling pathway
G0048471cellular_componentperinuclear region of cytoplasm
G0050681molecular_functionnuclear androgen receptor binding
G0050766biological_processpositive regulation of phagocytosis
G0050821biological_processprotein stabilization
G0051082molecular_functionunfolded protein binding
G0051087molecular_functionprotein-folding chaperone binding
G0051208biological_processsequestering of calcium ion
G0055007biological_processcardiac muscle cell differentiation
G0060473cellular_componentcortical granule
G0062023cellular_componentcollagen-containing extracellular matrix
G0070062cellular_componentextracellular exosome
G0071257biological_processcellular response to electrical stimulus
G0071285biological_processcellular response to lithium ion
G0071310biological_processcellular response to organic substance
G0071682cellular_componentendocytic vesicle lumen
G0090398biological_processcellular senescence
G0098553cellular_componentlumenal side of endoplasmic reticulum membrane
G0098586biological_processcellular response to virus
G0140313molecular_functionmolecular sequestering activity
G1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
G1901164biological_processnegative regulation of trophoblast cell migration
G1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
G1903416biological_processresponse to glycoside
G2000510biological_processpositive regulation of dendritic cell chemotaxis
Functional Information from PROSITE/UniProt
site_idPS00805
Number of Residues13
DetailsCALRETICULIN_REPEAT Calreticulin family repeated motif signature. IkDpDasKPEDWD
ChainResidueDetails
GILE208-ASP220
GILE225-ASP237
GILE242-ASP254

site_idPS00194
Number of Residues19
DetailsTHIOREDOXIN_1 Thioredoxin family active site. LVeFFapWCGHCKrLapeY
ChainResidueDetails
DLEU49-TYR67
DLEU398-TYR416

site_idPS00014
Number of Residues4
DetailsER_TARGET Endoplasmic reticulum targeting sequence. KDEL
ChainResidueDetails
GLYS414-LEU417

site_idPS00803
Number of Residues16
DetailsCALRETICULIN_1 Calreticulin family signature 1. KhEQnidCGGGYVKLF
ChainResidueDetails
GLYS98-PHE113

site_idPS00804
Number of Residues9
DetailsCALRETICULIN_2 Calreticulin family signature 2. IMFGPDiCG
ChainResidueDetails
GILE130-GLY138

site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCHVQH
ChainResidueDetails
FTYR257-HIS263
BTYR78-HIS84

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:21423620, ECO:0000269|PubMed:27840680, ECO:0007744|PDB:3POS, ECO:0007744|PDB:3POW, ECO:0007744|PDB:5LK5
ChainResidueDetails
GGLN26
GLYS62
GLYS64
GASP328

site_idSWS_FT_FI2
Number of Residues5
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P14211
ChainResidueDetails
GTYR109
GLYS111
GTYR128
GASP135
GASP317

site_idSWS_FT_FI3
Number of Residues3
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
GLYS48
GLYS159
GLYS209
DHIS408
BLYS91
BLYS94

site_idSWS_FT_FI4
Number of Residues1
DetailsMOD_RES: N6-(2-hydroxyisobutyryl)lysine => ECO:0000269|PubMed:29192674
ChainResidueDetails
GLYS64
FTHR73
FTYR84
FTHR143
FLYS146
FTYR171

site_idSWS_FT_FI5
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
ChainResidueDetails
GASN344
FTYR159

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: Sulfotyrosine => ECO:0000255
ChainResidueDetails
FTYR59

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
FSER319
FSER325
FSER326
FSER328

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:24275569
ChainResidueDetails
FTYR320
DLYS252
DLYS362
DLYS494

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
FSER332
FSER335

site_idSWS_FT_FI10
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
ChainResidueDetails
FASN86

218853

PDB entries from 2024-04-24

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