6ENS
Structure of mouse wild-type RKIP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000165 | biological_process | MAPK cascade |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0001933 | biological_process | negative regulation of protein phosphorylation |
| A | 0002026 | biological_process | regulation of the force of heart contraction |
| A | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| A | 0005102 | molecular_function | signaling receptor binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005741 | cellular_component | mitochondrial outer membrane |
| A | 0007286 | biological_process | spermatid development |
| A | 0008021 | cellular_component | synaptic vesicle |
| A | 0008289 | molecular_function | lipid binding |
| A | 0009986 | cellular_component | cell surface |
| A | 0019899 | molecular_function | enzyme binding |
| A | 0019900 | molecular_function | kinase binding |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0030414 | molecular_function | peptidase inhibitor activity |
| A | 0033612 | molecular_function | receptor serine/threonine kinase binding |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0043209 | cellular_component | myelin sheath |
| A | 0043409 | biological_process | negative regulation of MAPK cascade |
| A | 0043679 | cellular_component | axon terminus |
| A | 0045177 | cellular_component | apical part of cell |
| A | 0045840 | biological_process | positive regulation of mitotic nuclear division |
| A | 0048240 | biological_process | sperm capacitation |
| A | 0051019 | molecular_function | mitogen-activated protein kinase binding |
| A | 0060409 | biological_process | positive regulation of acetylcholine metabolic process |
| A | 0141163 | biological_process | positive regulation of cAMP/PKA signal transduction |
| A | 1905923 | biological_process | positive regulation of acetylcholine biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue ACT A 201 |
| Chain | Residue |
| A | HIS86 |
| A | GLY110 |
| A | TYR181 |
| A | HOH308 |
| A | HOH310 |
| A | HOH354 |
| A | HOH474 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 202 |
| Chain | Residue |
| A | ALA24 |
| A | ASP56 |
| A | ASN95 |
| A | ASP96 |
| A | HOH400 |
| A | GLN22 |
| A | HIS23 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 203 |
| Chain | Residue |
| A | GLU135 |
| A | PHE149 |
| A | LYS150 |
| A | THR153 |
| A | PHE154 |
| A | HOH318 |
| A | HOH371 |
| A | HOH446 |
| A | HOH469 |
Functional Information from PROSITE/UniProt
| site_id | PS01220 |
| Number of Residues | 23 |
| Details | PBP Phosphatidylethanolamine-binding protein family signature. YtLVlTDPDaPSrkdpkfrewhH |
| Chain | Residue | Details |
| A | TYR64-HIS86 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | Peptide: {"description":"Hippocampal cholinergic neurostimulating peptide","featureId":"PRO_0000023276"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 41 |
| Details | Region: {"description":"Interaction with RAF1","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N-acetylalanine; in peptide hippocampal cholinergic neurostimulating","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P30086","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P30086","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
