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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6EMK

Cryo-EM Structure of Saccharomyces cerevisiae Target of Rapamycin Complex 2

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000329cellular_componentfungal-type vacuole membrane
A0001558biological_processregulation of cell growth
A0004430molecular_function1-phosphatidylinositol 4-kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005774cellular_componentvacuolar membrane
A0005886cellular_componentplasma membrane
A0006995biological_processcellular response to nitrogen starvation
A0007010biological_processcytoskeleton organization
A0007584biological_processresponse to nutrient
A0010507biological_processnegative regulation of autophagy
A0016242biological_processnegative regulation of macroautophagy
A0016301molecular_functionkinase activity
A0016740molecular_functiontransferase activity
A0030950biological_processestablishment or maintenance of actin cytoskeleton polarity
A0031929biological_processTOR signaling
A0031931cellular_componentTORC1 complex
A0031932cellular_componentTORC2 complex
A0035025biological_processpositive regulation of Rho protein signal transduction
A0038201cellular_componentTOR complex
A0038202biological_processTORC1 signaling
A0042254biological_processribosome biogenesis
A0044877molecular_functionprotein-containing complex binding
A0045807biological_processpositive regulation of endocytosis
A0051726biological_processregulation of cell cycle
A0106310molecular_functionprotein serine kinase activity
A1905356biological_processregulation of snRNA pseudouridine synthesis
B0000139cellular_componentGolgi membrane
B0001558biological_processregulation of cell growth
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005774cellular_componentvacuolar membrane
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0007165biological_processsignal transduction
B0007584biological_processresponse to nutrient
B0010008cellular_componentendosome membrane
B0030950biological_processestablishment or maintenance of actin cytoskeleton polarity
B0031505biological_processfungal-type cell wall organization
B0031929biological_processTOR signaling
B0031930biological_processmitochondria-nucleus signaling pathway
B0031931cellular_componentTORC1 complex
B0031932cellular_componentTORC2 complex
B0032956biological_processregulation of actin cytoskeleton organization
B0034399cellular_componentnuclear periphery
B0043539molecular_functionprotein serine/threonine kinase activator activity
B0051726biological_processregulation of cell cycle
B0098588cellular_componentbounding membrane of organelle
C0000166molecular_functionnucleotide binding
C0000329cellular_componentfungal-type vacuole membrane
C0001558biological_processregulation of cell growth
C0004430molecular_function1-phosphatidylinositol 4-kinase activity
C0004674molecular_functionprotein serine/threonine kinase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005774cellular_componentvacuolar membrane
C0005886cellular_componentplasma membrane
C0006995biological_processcellular response to nitrogen starvation
C0007010biological_processcytoskeleton organization
C0007584biological_processresponse to nutrient
C0010507biological_processnegative regulation of autophagy
C0016242biological_processnegative regulation of macroautophagy
C0016301molecular_functionkinase activity
C0016740molecular_functiontransferase activity
C0030950biological_processestablishment or maintenance of actin cytoskeleton polarity
C0031929biological_processTOR signaling
C0031931cellular_componentTORC1 complex
C0031932cellular_componentTORC2 complex
C0035025biological_processpositive regulation of Rho protein signal transduction
C0038201cellular_componentTOR complex
C0038202biological_processTORC1 signaling
C0042254biological_processribosome biogenesis
C0044877molecular_functionprotein-containing complex binding
C0045807biological_processpositive regulation of endocytosis
C0051726biological_processregulation of cell cycle
C0106310molecular_functionprotein serine kinase activity
C1905356biological_processregulation of snRNA pseudouridine synthesis
D0000139cellular_componentGolgi membrane
D0001558biological_processregulation of cell growth
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005774cellular_componentvacuolar membrane
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0007165biological_processsignal transduction
D0007584biological_processresponse to nutrient
D0010008cellular_componentendosome membrane
D0030950biological_processestablishment or maintenance of actin cytoskeleton polarity
D0031505biological_processfungal-type cell wall organization
D0031929biological_processTOR signaling
D0031930biological_processmitochondria-nucleus signaling pathway
D0031931cellular_componentTORC1 complex
D0031932cellular_componentTORC2 complex
D0032956biological_processregulation of actin cytoskeleton organization
D0034399cellular_componentnuclear periphery
D0043539molecular_functionprotein serine/threonine kinase activator activity
D0051726biological_processregulation of cell cycle
D0098588cellular_componentbounding membrane of organelle
G0001558biological_processregulation of cell growth
G0003674molecular_functionmolecular_function
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005737cellular_componentcytoplasm
G0005774cellular_componentvacuolar membrane
G0005829cellular_componentcytosol
G0005886cellular_componentplasma membrane
G0030950biological_processestablishment or maintenance of actin cytoskeleton polarity
G0031929biological_processTOR signaling
G0031932cellular_componentTORC2 complex
H0001558biological_processregulation of cell growth
H0003674molecular_functionmolecular_function
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005737cellular_componentcytoplasm
H0005774cellular_componentvacuolar membrane
H0005829cellular_componentcytosol
H0005886cellular_componentplasma membrane
H0030950biological_processestablishment or maintenance of actin cytoskeleton polarity
H0031929biological_processTOR signaling
H0031932cellular_componentTORC2 complex
I0001558biological_processregulation of cell growth
I0005515molecular_functionprotein binding
I0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
I0005737cellular_componentcytoplasm
I0005774cellular_componentvacuolar membrane
I0005886cellular_componentplasma membrane
I0030950biological_processestablishment or maintenance of actin cytoskeleton polarity
I0031929biological_processTOR signaling
I0031932cellular_componentTORC2 complex
I0038203biological_processTORC2 signaling
I0060090molecular_functionmolecular adaptor activity
J0001558biological_processregulation of cell growth
J0005515molecular_functionprotein binding
J0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
J0005737cellular_componentcytoplasm
J0005774cellular_componentvacuolar membrane
J0005886cellular_componentplasma membrane
J0030950biological_processestablishment or maintenance of actin cytoskeleton polarity
J0031929biological_processTOR signaling
J0031932cellular_componentTORC2 complex
J0038203biological_processTORC2 signaling
J0060090molecular_functionmolecular adaptor activity
Functional Information from PROSITE/UniProt
site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAgyDhTIRFWEA
ChainResidueDetails
BLEU5-ALA19
BMET90-VAL104
BLEU131-LEU145
BLEU265-LEU279
site_idPS00915
Number of Residues15
DetailsPI3_4_KINASE_1 Phosphatidylinositol 3- and 4-kinases signature 1. LKgh.EDIRQDslvmQ
ChainResidueDetails
ALEU2125-GLN2139
site_idPS00916
Number of Residues21
DetailsPI3_4_KINASE_2 Phosphatidylinositol 3- and 4-kinases signature 2. SlAvmsMtgYILgLgDRHpsN
ChainResidueDetails
ASER2262-ASN2282
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues76
DetailsRepeat: {"description":"HEAT 1"}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues76
DetailsRepeat: {"description":"HEAT 2"}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues68
DetailsRepeat: {"description":"HEAT 3"}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues74
DetailsRepeat: {"description":"HEAT 4"}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues76
DetailsRepeat: {"description":"HEAT 5"}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues76
DetailsRepeat: {"description":"HEAT 7"}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues74
DetailsRepeat: {"description":"HEAT 8"}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues74
DetailsRepeat: {"description":"HEAT 9"}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues74
DetailsRepeat: {"description":"HEAT 10"}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues648
DetailsDomain: {"description":"PI3K/PI4K catalytic","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues64
DetailsDomain: {"description":"FATC","evidences":[{"source":"PROSITE-ProRule","id":"PRU00534","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU00535","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues12
DetailsRegion: {"description":"G-loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues16
DetailsRegion: {"description":"Catalytic loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues50
DetailsRegion: {"description":"Activation loop","evidences":[{"source":"PROSITE-ProRule","id":"PRU00269","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues76
DetailsRepeat: {"description":"WD 2"}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues78
DetailsRepeat: {"description":"WD 3"}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues78
DetailsRepeat: {"description":"WD 4"}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues78
DetailsRepeat: {"description":"WD 5"}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues78
DetailsRepeat: {"description":"WD 6"}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues78
DetailsRepeat: {"description":"WD 7"}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues60
DetailsRepeat: {"description":"ANK 3"}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues58
DetailsRepeat: {"description":"ANK 4"}
ChainResidueDetails

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PDB entries from 2025-10-08

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