6EKS
Vibrio cholerae neuraminidase complexed with oseltamivir carboxylate
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004308 | molecular_function | exo-alpha-sialidase activity |
A | 0005576 | cellular_component | extracellular region |
A | 0005737 | cellular_component | cytoplasm |
A | 0006689 | biological_process | ganglioside catabolic process |
A | 0009313 | biological_process | oligosaccharide catabolic process |
A | 0016020 | cellular_component | membrane |
A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
A | 0033691 | molecular_function | sialic acid binding |
A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
A | 0052794 | molecular_function | exo-alpha-(2->3)-sialidase activity |
A | 0052795 | molecular_function | exo-alpha-(2->6)-sialidase activity |
A | 0052796 | molecular_function | exo-alpha-(2->8)-sialidase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | binding site for residue CA A 901 |
Chain | Residue |
A | ASP312 |
A | HOH1230 |
A | HOH1258 |
A | HOH1266 |
A | HOH1301 |
A | HOH1609 |
A | HOH1682 |
site_id | AC2 |
Number of Residues | 6 |
Details | binding site for residue CA A 902 |
Chain | Residue |
A | HOH1051 |
A | HOH1167 |
A | HOH1171 |
A | HOH1595 |
A | ASP346 |
A | PHE604 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue CA A 903 |
Chain | Residue |
A | PRO574 |
A | ASP647 |
A | ASP708 |
A | ALA709 |
A | HOH1321 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue CA A 904 |
Chain | Residue |
A | ALA279 |
A | ASN282 |
A | ASP315 |
A | THR339 |
site_id | AC5 |
Number of Residues | 11 |
Details | binding site for residue GOL A 905 |
Chain | Residue |
A | GLN384 |
A | VAL415 |
A | ARG514 |
A | HIS516 |
A | ASN567 |
A | THR625 |
A | HOH1069 |
A | HOH1221 |
A | HOH1427 |
A | HOH1469 |
A | HOH1502 |
site_id | AC6 |
Number of Residues | 9 |
Details | binding site for residue GOL A 906 |
Chain | Residue |
A | VAL415 |
A | ASP416 |
A | ASN607 |
A | THR625 |
A | LEU626 |
A | PRO627 |
A | ILE628 |
A | HOH1143 |
A | HOH1543 |
site_id | AC7 |
Number of Residues | 6 |
Details | binding site for residue GOL A 907 |
Chain | Residue |
A | PRO350 |
A | LEU564 |
A | TYR565 |
A | HOH1269 |
A | HOH1371 |
A | HOH1521 |
site_id | AC8 |
Number of Residues | 18 |
Details | binding site for residue G39 A 908 |
Chain | Residue |
A | ARG250 |
A | ILE251 |
A | ARG271 |
A | ASP276 |
A | GLN343 |
A | ASN344 |
A | ASN571 |
A | GLU645 |
A | ARG661 |
A | ASP663 |
A | ARG738 |
A | TYR766 |
A | HOH1133 |
A | HOH1205 |
A | HOH1274 |
A | HOH1477 |
A | HOH1486 |
A | HOH1520 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Proton acceptor => ECO:0000250 |
Chain | Residue | Details |
A | ASP276 |
site_id | SWS_FT_FI2 |
Number of Residues | 1 |
Details | ACT_SITE: ACT_SITE => ECO:0000255 |
Chain | Residue | Details |
A | GLU645 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | ACT_SITE: Nucleophile => ECO:0000250 |
Chain | Residue | Details |
A | TYR766 |
site_id | SWS_FT_FI4 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | ARG250 | |
A | ARG661 | |
A | ARG738 |