6EIC

Crystal structure of Rv0183, a Monoglyceride Lipase from Mycobacterium Tuberculosis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004622	molecular_function	phosphatidylcholine lysophospholipase activity
A	0005576	cellular_component	extracellular region
A	0005886	cellular_component	plasma membrane
A	0006629	biological_process	lipid metabolic process
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0016020	cellular_component	membrane
A	0016042	biological_process	lipid catabolic process
A	0016298	molecular_function	lipase activity
A	0016787	molecular_function	hydrolase activity
A	0046503	biological_process	glycerolipid catabolic process
A	0047372	molecular_function	monoacylglycerol lipase activity
A	0052151	biological_process	symbiont-mediated activation of host apoptosis
B	0004622	molecular_function	phosphatidylcholine lysophospholipase activity
B	0005576	cellular_component	extracellular region
B	0005886	cellular_component	plasma membrane
B	0006629	biological_process	lipid metabolic process
B	0009274	cellular_component	peptidoglycan-based cell wall
B	0016020	cellular_component	membrane
B	0016042	biological_process	lipid catabolic process
B	0016298	molecular_function	lipase activity
B	0016787	molecular_function	hydrolase activity
B	0046503	biological_process	glycerolipid catabolic process
B	0047372	molecular_function	monoacylglycerol lipase activity
B	0052151	biological_process	symbiont-mediated activation of host apoptosis
C	0004622	molecular_function	phosphatidylcholine lysophospholipase activity
C	0005576	cellular_component	extracellular region
C	0005886	cellular_component	plasma membrane
C	0006629	biological_process	lipid metabolic process
C	0009274	cellular_component	peptidoglycan-based cell wall
C	0016020	cellular_component	membrane
C	0016042	biological_process	lipid catabolic process
C	0016298	molecular_function	lipase activity
C	0016787	molecular_function	hydrolase activity
C	0046503	biological_process	glycerolipid catabolic process
C	0047372	molecular_function	monoacylglycerol lipase activity
C	0052151	biological_process	symbiont-mediated activation of host apoptosis

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue SO4 C 301

Chain	Residue
C	LEU39
C	LEU166
C	HOH422

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site_id	AC2
Number of Residues	6
Details	binding site for residue MPD C 302

Chain	Residue
C	LEU39
C	GLU41
C	HIS109
C	SER110
C	HIS256
C	GLU257

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site_id	AC3
Number of Residues	7
Details	binding site for residue MPD A 301

Chain	Residue
A	LEU39
A	HIS109
A	SER110
A	TYR181
A	LEU228
A	HIS256
A	GLU257

---

site_id	AC4
Number of Residues	7
Details	binding site for residue MPD B 301

Chain	Residue
B	GLY38
B	LEU39
B	ARG45
B	HIS109
B	TYR181
B	HIS256
B	GLU257

---

site_id	AC5
Number of Residues	3
Details	binding site for residue NO3 B 302

Chain	Residue
B	LEU39
B	LEU200
B	HOH428

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Nucleophile => ECO:0000305|PubMed:17784850, ECO:0000305|PubMed:29895832

Chain	Residue	Details
C	SER110
A	SER110
B	SER110

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site_id	SWS_FT_FI2
Number of Residues	6
Details	ACT_SITE: Charge relay system => ECO:0000305|PubMed:17784850, ECO:0000305|PubMed:29895832

Chain	Residue	Details
C	ASP226
C	HIS256
A	ASP226
A	HIS256
B	ASP226
B	HIS256

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