6EFG
Pyruvate decarboxylase from Kluyveromyces lactis
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0000949 | biological_process | aromatic amino acid family catabolic process to alcohol via Ehrlich pathway |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004737 | molecular_function | pyruvate decarboxylase activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0005829 | cellular_component | cytosol |
| A | 0016829 | molecular_function | lyase activity |
| A | 0016831 | molecular_function | carboxy-lyase activity |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| A | 0030976 | molecular_function | thiamine pyrophosphate binding |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0000949 | biological_process | aromatic amino acid family catabolic process to alcohol via Ehrlich pathway |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004737 | molecular_function | pyruvate decarboxylase activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005829 | cellular_component | cytosol |
| B | 0016829 | molecular_function | lyase activity |
| B | 0016831 | molecular_function | carboxy-lyase activity |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0030976 | molecular_function | thiamine pyrophosphate binding |
| B | 0046872 | molecular_function | metal ion binding |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0000949 | biological_process | aromatic amino acid family catabolic process to alcohol via Ehrlich pathway |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004737 | molecular_function | pyruvate decarboxylase activity |
| D | 0005634 | cellular_component | nucleus |
| D | 0005829 | cellular_component | cytosol |
| D | 0016829 | molecular_function | lyase activity |
| D | 0016831 | molecular_function | carboxy-lyase activity |
| D | 0019752 | biological_process | carboxylic acid metabolic process |
| D | 0030976 | molecular_function | thiamine pyrophosphate binding |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0000287 | molecular_function | magnesium ion binding |
| E | 0000949 | biological_process | aromatic amino acid family catabolic process to alcohol via Ehrlich pathway |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004737 | molecular_function | pyruvate decarboxylase activity |
| E | 0005634 | cellular_component | nucleus |
| E | 0005829 | cellular_component | cytosol |
| E | 0016829 | molecular_function | lyase activity |
| E | 0016831 | molecular_function | carboxy-lyase activity |
| E | 0019752 | biological_process | carboxylic acid metabolic process |
| E | 0030976 | molecular_function | thiamine pyrophosphate binding |
| E | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | binding site for residue TPP A 600 |
| Chain | Residue |
| A | THR390 |
| A | GLY473 |
| A | TYR474 |
| A | THR475 |
| A | ILE476 |
| A | MG601 |
| A | HOH715 |
| A | HOH720 |
| A | HOH752 |
| B | PRO26 |
| B | GLY27 |
| A | GLY413 |
| B | GLU51 |
| B | VAL76 |
| A | SER414 |
| A | ILE415 |
| A | GLY443 |
| A | ASP444 |
| A | GLY445 |
| A | SER446 |
| A | ASN471 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 601 |
| Chain | Residue |
| A | ASP444 |
| A | ASN471 |
| A | GLY473 |
| A | TPP600 |
| A | HOH715 |
| site_id | AC3 |
| Number of Residues | 21 |
| Details | binding site for residue TPP B 600 |
| Chain | Residue |
| A | PRO26 |
| A | GLY27 |
| A | ASP28 |
| A | GLU51 |
| A | VAL76 |
| B | THR390 |
| B | GLY413 |
| B | SER414 |
| B | ILE415 |
| B | GLY443 |
| B | ASP444 |
| B | GLY445 |
| B | SER446 |
| B | ASN471 |
| B | GLY473 |
| B | TYR474 |
| B | THR475 |
| B | ILE476 |
| B | MG601 |
| B | HOH705 |
| B | HOH720 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 601 |
| Chain | Residue |
| B | ASP444 |
| B | ASN471 |
| B | GLY473 |
| B | TPP600 |
| B | HOH705 |
| site_id | AC5 |
| Number of Residues | 23 |
| Details | binding site for residue TPP D 600 |
| Chain | Residue |
| D | GLY389 |
| D | THR390 |
| D | GLY413 |
| D | SER414 |
| D | ILE415 |
| D | GLY443 |
| D | ASP444 |
| D | GLY445 |
| D | SER446 |
| D | ASN471 |
| D | GLY473 |
| D | TYR474 |
| D | THR475 |
| D | ILE476 |
| D | GLU477 |
| D | MG601 |
| D | HOH703 |
| D | HOH715 |
| D | HOH731 |
| E | PRO26 |
| E | GLY27 |
| E | GLU51 |
| E | VAL76 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue MG D 601 |
| Chain | Residue |
| D | ASP444 |
| D | ASN471 |
| D | GLY473 |
| D | TPP600 |
| D | HOH703 |
| site_id | AC7 |
| Number of Residues | 22 |
| Details | binding site for residue TPP E 600 |
| Chain | Residue |
| E | HOH710 |
| E | HOH722 |
| E | HOH727 |
| D | PRO26 |
| D | GLY27 |
| D | GLU51 |
| D | VAL76 |
| E | GLY389 |
| E | THR390 |
| E | GLY413 |
| E | SER414 |
| E | ILE415 |
| E | GLY443 |
| E | ASP444 |
| E | GLY445 |
| E | SER446 |
| E | ASN471 |
| E | GLY473 |
| E | TYR474 |
| E | THR475 |
| E | ILE476 |
| E | MG601 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue MG E 601 |
| Chain | Residue |
| E | ASP444 |
| E | ASN471 |
| E | GLY473 |
| E | TPP600 |
| E | HOH710 |
Functional Information from PROSITE/UniProt
| site_id | PS00187 |
| Number of Residues | 20 |
| Details | TPP_ENZYMES Thiamine pyrophosphate enzymes signature. FAaeeidPkkrvIlFiGDGS |
| Chain | Residue | Details |
| A | PHE427-SER446 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 59 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P06169","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
