Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070733 | molecular_function | AMPylase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016779 | molecular_function | nucleotidyltransferase activity |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070733 | molecular_function | AMPylase activity |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016779 | molecular_function | nucleotidyltransferase activity |
| C | 0030145 | molecular_function | manganese ion binding |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0070733 | molecular_function | AMPylase activity |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0005524 | molecular_function | ATP binding |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016779 | molecular_function | nucleotidyltransferase activity |
| D | 0030145 | molecular_function | manganese ion binding |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0070733 | molecular_function | AMPylase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue MG A 501 |
| Chain | Residue |
| A | ASN253 |
| A | ASP262 |
| A | ANP506 |
| A | HOH656 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 502 |
| Chain | Residue |
| A | ASP262 |
| A | ANP506 |
| A | HOH737 |
| A | HOH744 |
| A | HOH774 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue CA A 503 |
| Chain | Residue |
| A | SER362 |
| A | GLY363 |
| A | ASP388 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 504 |
| Chain | Residue |
| A | GLN357 |
| A | LEU358 |
| A | ASN361 |
| A | HOH759 |
| A | HOH771 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 505 |
| Chain | Residue |
| A | ARG93 |
| A | ALA128 |
| A | VAL129 |
| A | ARG165 |
| site_id | AC6 |
| Number of Residues | 23 |
| Details | binding site for residue ANP A 506 |
| Chain | Residue |
| A | TYR77 |
| A | GLY90 |
| A | GLY92 |
| A | ARG93 |
| A | LYS113 |
| A | ARG122 |
| A | GLY124 |
| A | ASP125 |
| A | GLY126 |
| A | ARG127 |
| A | ARG176 |
| A | ARG183 |
| A | ASN253 |
| A | ASP262 |
| A | MG501 |
| A | CA502 |
| A | HOH622 |
| A | HOH652 |
| A | HOH656 |
| A | HOH690 |
| A | HOH737 |
| A | HOH745 |
| B | TRP164 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 507 |
| Chain | Residue |
| A | GLU410 |
| A | HOH757 |
| A | HOH763 |
| A | HOH766 |
| A | HOH788 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 508 |
| Chain | Residue |
| A | MET75 |
| A | ASP109 |
| A | GLN179 |
| A | SER180 |
| A | HIS181 |
| A | HIS205 |
| A | HIS210 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 509 |
| Chain | Residue |
| A | GLN240 |
| A | PHE289 |
| A | TYR327 |
| A | LEU356 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 510 |
| Chain | Residue |
| A | ALA37 |
| A | SER38 |
| A | GLU39 |
| A | HIS454 |
| A | GLN455 |
| A | HOH704 |
| site_id | AD2 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 511 |
| Chain | Residue |
| A | LEU146 |
| A | GLY147 |
| A | TYR242 |
| A | HOH601 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 512 |
| Chain | Residue |
| A | ASP333 |
| A | ARG336 |
| B | HOH645 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 513 |
| Chain | Residue |
| A | PRO377 |
| A | ALA378 |
| A | ILE406 |
| A | GLU414 |
| A | ARG417 |
| A | HOH725 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 514 |
| Chain | Residue |
| A | TRP108 |
| A | HIS144 |
| A | SER150 |
| A | ARG152 |
| A | HOH729 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 515 |
| Chain | Residue |
| A | ARG117 |
| A | ASP125 |
| A | ARG127 |
| A | THR161 |
| site_id | AD7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 516 |
| Chain | Residue |
| A | GLU27 |
| A | ARG117 |
| B | ASP396 |
| B | ASP397 |
| B | GLN400 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue PEG A 517 |
| Chain | Residue |
| A | TRP298 |
| A | SER301 |
| A | ALA302 |
| A | GLN305 |
| site_id | AD9 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 518 |
| Chain | Residue |
| A | GLN305 |
| A | ARG317 |
| A | HOH618 |
| A | SER301 |
| A | GLY304 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue ACT A 519 |
| Chain | Residue |
| A | ARG371 |
| A | ASP375 |
| A | HIS422 |
| A | LEU427 |
| A | GLU463 |
| site_id | AE2 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 501 |
| Chain | Residue |
| B | ASN253 |
| B | ASP262 |
| B | ANP507 |
| B | HOH618 |
| site_id | AE3 |
| Number of Residues | 5 |
| Details | binding site for residue CA B 502 |
| Chain | Residue |
| B | ASP262 |
| B | ANP507 |
| B | HOH713 |
| B | HOH731 |
| B | HOH762 |
| site_id | AE4 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 503 |
| Chain | Residue |
| B | SER362 |
| B | GLY363 |
| B | ASP388 |
| B | HOH692 |
| B | HOH740 |
| B | HOH763 |
| site_id | AE5 |
| Number of Residues | 3 |
| Details | binding site for residue CA B 504 |
| Chain | Residue |
| B | GLU410 |
| B | HOH682 |
| B | HOH761 |
| site_id | AE6 |
| Number of Residues | 4 |
| Details | binding site for residue CA B 505 |
| Chain | Residue |
| A | HOH751 |
| B | ALA68 |
| B | ALA70 |
| B | HOH764 |
| site_id | AE7 |
| Number of Residues | 4 |
| Details | binding site for residue CL B 506 |
| Chain | Residue |
| B | ARG93 |
| B | VAL129 |
| B | SER132 |
| B | ARG165 |
| site_id | AE8 |
| Number of Residues | 23 |
| Details | binding site for residue ANP B 507 |
| Chain | Residue |
| A | TRP164 |
| B | TYR77 |
| B | LEU89 |
| B | GLY90 |
| B | GLY92 |
| B | ARG93 |
| B | LYS113 |
| B | GLY124 |
| B | ASP125 |
| B | GLY126 |
| B | ARG127 |
| B | ARG176 |
| B | ARG183 |
| B | ASN253 |
| B | ASP262 |
| B | MG501 |
| B | CA502 |
| B | HOH618 |
| B | HOH658 |
| B | HOH683 |
| B | HOH695 |
| B | HOH713 |
| B | HOH739 |
| site_id | AE9 |
| Number of Residues | 8 |
| Details | binding site for residue EDO B 508 |
| Chain | Residue |
| B | PHE13 |
| B | MET75 |
| B | GLU99 |
| B | ASP109 |
| B | GLN179 |
| B | SER180 |
| B | HIS181 |
| B | HOH607 |
| site_id | AF1 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 509 |
| Chain | Residue |
| B | HIS80 |
| B | TYR192 |
| B | HOH602 |
| C | ARG15 |
| site_id | AF2 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 510 |
| Chain | Residue |
| B | ALA43 |
| B | ASP46 |
| B | ASN102 |
| B | ASP103 |
| B | ALA104 |
| site_id | AF3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 511 |
| Chain | Residue |
| B | LEU146 |
| B | GLY147 |
| B | LYS238 |
| B | TYR242 |
| B | HOH609 |
| B | HOH724 |
| site_id | AF4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 512 |
| Chain | Residue |
| A | GLU227 |
| A | GLU230 |
| B | GLU227 |
| B | GLU230 |
| site_id | AF5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 513 |
| Chain | Residue |
| B | ASP270 |
| B | ASP271 |
| B | ASP273 |
| B | PHE276 |
| site_id | AF6 |
| Number of Residues | 3 |
| Details | binding site for residue PEG B 514 |
| Chain | Residue |
| B | TRP298 |
| B | SER301 |
| B | GLN305 |
| site_id | AF7 |
| Number of Residues | 4 |
| Details | binding site for residue ACT B 515 |
| Chain | Residue |
| B | SER301 |
| B | GLN305 |
| B | THR308 |
| B | ARG317 |
| site_id | AF8 |
| Number of Residues | 4 |
| Details | binding site for residue MG C 501 |
| Chain | Residue |
| C | ASN253 |
| C | ASP262 |
| C | ANP506 |
| C | HOH642 |
| site_id | AF9 |
| Number of Residues | 5 |
| Details | binding site for residue CA C 502 |
| Chain | Residue |
| C | ASP262 |
| C | ANP506 |
| C | HOH703 |
| C | HOH715 |
| C | HOH717 |
| site_id | AG1 |
| Number of Residues | 4 |
| Details | binding site for residue CA C 503 |
| Chain | Residue |
| C | SER362 |
| C | GLY363 |
| C | ASP388 |
| C | HOH714 |
| site_id | AG2 |
| Number of Residues | 3 |
| Details | binding site for residue CA C 504 |
| Chain | Residue |
| A | HOH786 |
| C | ASP46 |
| C | HOH719 |
| site_id | AG3 |
| Number of Residues | 5 |
| Details | binding site for residue CL C 505 |
| Chain | Residue |
| C | ARG93 |
| C | ALA128 |
| C | VAL129 |
| C | SER132 |
| C | ARG165 |
| site_id | AG4 |
| Number of Residues | 24 |
| Details | binding site for residue ANP C 506 |
| Chain | Residue |
| C | TYR77 |
| C | LEU89 |
| C | GLY90 |
| C | GLY92 |
| C | ARG93 |
| C | LYS113 |
| C | SER121 |
| C | ARG122 |
| C | GLY124 |
| C | ASP125 |
| C | GLY126 |
| C | ARG127 |
| C | ARG165 |
| C | ARG176 |
| C | ARG183 |
| C | ASN253 |
| C | ASP262 |
| C | MG501 |
| C | CA502 |
| C | HOH605 |
| C | HOH616 |
| C | HOH642 |
| C | HOH668 |
| C | HOH701 |
| site_id | AG5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 507 |
| Chain | Residue |
| C | TRP67 |
| C | ALA70 |
| C | PRO72 |
| site_id | AG6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO C 508 |
| Chain | Residue |
| C | LEU368 |
| C | ARG372 |
| C | GLN380 |
| site_id | AG7 |
| Number of Residues | 4 |
| Details | binding site for residue PEG C 509 |
| Chain | Residue |
| C | TYR192 |
| C | TRP298 |
| C | SER301 |
| C | GLN305 |
| site_id | AG8 |
| Number of Residues | 4 |
| Details | binding site for residue PEG C 510 |
| Chain | Residue |
| C | THR22 |
| C | ARG88 |
| C | PRO119 |
| C | TYR120 |
| site_id | AG9 |
| Number of Residues | 3 |
| Details | binding site for residue ACT C 511 |
| Chain | Residue |
| C | ARG122 |
| C | MET123 |
| C | GLY124 |
| site_id | AH1 |
| Number of Residues | 4 |
| Details | binding site for residue MG D 501 |
| Chain | Residue |
| D | ASN253 |
| D | ASP262 |
| D | ANP506 |
| D | HOH617 |
| site_id | AH2 |
| Number of Residues | 5 |
| Details | binding site for residue CA D 502 |
| Chain | Residue |
| D | ASP262 |
| D | ANP506 |
| D | HOH688 |
| D | HOH706 |
| D | HOH707 |
| site_id | AH3 |
| Number of Residues | 3 |
| Details | binding site for residue CA D 503 |
| Chain | Residue |
| D | SER362 |
| D | GLY363 |
| D | ASP388 |
| site_id | AH4 |
| Number of Residues | 3 |
| Details | binding site for residue CA D 504 |
| Chain | Residue |
| B | HOH768 |
| D | ASP46 |
| D | HOH664 |
| site_id | AH5 |
| Number of Residues | 5 |
| Details | binding site for residue CL D 505 |
| Chain | Residue |
| D | ARG93 |
| D | ALA128 |
| D | VAL129 |
| D | SER132 |
| D | ARG165 |
| site_id | AH6 |
| Number of Residues | 24 |
| Details | binding site for residue ANP D 506 |
| Chain | Residue |
| D | TYR77 |
| D | LEU89 |
| D | GLY90 |
| D | GLY92 |
| D | ARG93 |
| D | LYS113 |
| D | SER121 |
| D | ARG122 |
| D | GLY124 |
| D | ASP125 |
| D | GLY126 |
| D | ARG127 |
| D | ARG165 |
| D | ARG176 |
| D | ARG183 |
| D | ASP252 |
| D | ASN253 |
| D | ASP262 |
| D | MG501 |
| D | CA502 |
| D | HOH612 |
| D | HOH617 |
| D | HOH634 |
| D | HOH641 |
| site_id | AH7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO D 507 |
| Chain | Residue |
| D | PHE13 |
| D | ASP109 |
| D | GLN179 |
| D | HIS181 |
| D | HOH629 |
| site_id | AH8 |
| Number of Residues | 6 |
| Details | binding site for residue EDO D 508 |
| Chain | Residue |
| A | THR193 |
| A | LYS194 |
| D | ASN11 |
| D | GLU69 |
| D | GLU71 |
| D | HOH657 |
| site_id | AH9 |
| Number of Residues | 4 |
| Details | binding site for residue EDO D 509 |
| Chain | Residue |
| D | HIS144 |
| D | SER150 |
| D | ARG152 |
| D | HOH696 |
| site_id | AI1 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 510 |
| Chain | Residue |
| D | THR22 |
| D | ARG88 |
| D | TYR120 |
| site_id | AI2 |
| Number of Residues | 3 |
| Details | binding site for residue PEG D 511 |
| Chain | Residue |
| D | TYR192 |
| D | TRP298 |
| D | SER301 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"30270044","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"30270044","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6EAC","evidenceCode":"ECO:0007744"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"30270044","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6EAC","evidenceCode":"ECO:0007744"}]} |
