6EA6
Structure of VACV poxin 2'3' cGAMP-specific nuclease
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004518 | molecular_function | nuclease activity |
| A | 0030430 | cellular_component | host cell cytoplasm |
| A | 0052170 | biological_process | symbiont-mediated suppression of host innate immune response |
| A | 0061507 | molecular_function | 2',3'-cyclic GMP-AMP binding |
| B | 0004518 | molecular_function | nuclease activity |
| B | 0030430 | cellular_component | host cell cytoplasm |
| B | 0052170 | biological_process | symbiont-mediated suppression of host innate immune response |
| B | 0061507 | molecular_function | 2',3'-cyclic GMP-AMP binding |
| C | 0004518 | molecular_function | nuclease activity |
| C | 0030430 | cellular_component | host cell cytoplasm |
| C | 0052170 | biological_process | symbiont-mediated suppression of host innate immune response |
| C | 0061507 | molecular_function | 2',3'-cyclic GMP-AMP binding |
| D | 0004518 | molecular_function | nuclease activity |
| D | 0030430 | cellular_component | host cell cytoplasm |
| D | 0052170 | biological_process | symbiont-mediated suppression of host innate immune response |
| D | 0061507 | molecular_function | 2',3'-cyclic GMP-AMP binding |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_04143, ECO:0000269|PubMed:30728498 |
| Chain | Residue | Details |
| A | HIS17 | |
| C | HIS17 | |
| B | HIS17 | |
| D | HIS17 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: Shared with catalytic histidine of dimeric partner => ECO:0000255|HAMAP-Rule:MF_04143, ECO:0000269|PubMed:30728498 |
| Chain | Residue | Details |
| A | TYR138 | |
| C | TYR138 | |
| B | TYR138 | |
| D | TYR138 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor; shared with catalytic histidine of dimeric partner => ECO:0000255|HAMAP-Rule:MF_04143, ECO:0000269|PubMed:30728498 |
| Chain | Residue | Details |
| A | LYS142 | |
| C | LYS142 | |
| B | LYS142 | |
| D | LYS142 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 28 |
| Details | SITE: Substrate binding => ECO:0000255|HAMAP-Rule:MF_04143, ECO:0000269|PubMed:30728498 |
| Chain | Residue | Details |
| A | ARG60 | |
| C | ASN149 | |
| C | GLN169 | |
| C | ARG182 | |
| C | ARG184 | |
| C | LYS186 | |
| B | ARG60 | |
| B | ILE105 | |
| B | ASN149 | |
| B | GLN169 | |
| B | ARG182 | |
| A | ILE105 | |
| B | ARG184 | |
| B | LYS186 | |
| D | ARG60 | |
| D | ILE105 | |
| D | ASN149 | |
| D | GLN169 | |
| D | ARG182 | |
| D | ARG184 | |
| D | LYS186 | |
| A | ASN149 | |
| A | GLN169 | |
| A | ARG182 | |
| A | ARG184 | |
| A | LYS186 | |
| C | ARG60 | |
| C | ILE105 |
