6EA6
Structure of VACV poxin 2'3' cGAMP-specific nuclease
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004518 | molecular_function | nuclease activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030430 | cellular_component | host cell cytoplasm |
| A | 0052170 | biological_process | symbiont-mediated suppression of host innate immune response |
| A | 0061507 | molecular_function | 2',3'-cyclic GMP-AMP binding |
| B | 0004518 | molecular_function | nuclease activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0030430 | cellular_component | host cell cytoplasm |
| B | 0052170 | biological_process | symbiont-mediated suppression of host innate immune response |
| B | 0061507 | molecular_function | 2',3'-cyclic GMP-AMP binding |
| C | 0004518 | molecular_function | nuclease activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0030430 | cellular_component | host cell cytoplasm |
| C | 0052170 | biological_process | symbiont-mediated suppression of host innate immune response |
| C | 0061507 | molecular_function | 2',3'-cyclic GMP-AMP binding |
| D | 0004518 | molecular_function | nuclease activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0030430 | cellular_component | host cell cytoplasm |
| D | 0052170 | biological_process | symbiont-mediated suppression of host innate immune response |
| D | 0061507 | molecular_function | 2',3'-cyclic GMP-AMP binding |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"HAMAP-Rule","id":"MF_04143","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"30728498","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Shared with catalytic histidine of dimeric partner","evidences":[{"source":"HAMAP-Rule","id":"MF_04143","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"30728498","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor; shared with catalytic histidine of dimeric partner","evidences":[{"source":"HAMAP-Rule","id":"MF_04143","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"30728498","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 16 |
| Details | Site: {"description":"Substrate binding","evidences":[{"source":"HAMAP-Rule","id":"MF_04143","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"30728498","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
