6E90
Ternary complex of human glycerol 3-phosphate dehydrogenase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006072 | biological_process | glycerol-3-phosphate metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0046168 | biological_process | glycerol-3-phosphate catabolic process |
| A | 0047952 | molecular_function | glycerol-3-phosphate dehydrogenase [NAD(P)+] activity |
| A | 0051287 | molecular_function | NAD binding |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0141152 | molecular_function | glycerol-3-phosphate dehydrogenase (NAD+) activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006072 | biological_process | glycerol-3-phosphate metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0046168 | biological_process | glycerol-3-phosphate catabolic process |
| B | 0047952 | molecular_function | glycerol-3-phosphate dehydrogenase [NAD(P)+] activity |
| B | 0051287 | molecular_function | NAD binding |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0141152 | molecular_function | glycerol-3-phosphate dehydrogenase (NAD+) activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0006072 | biological_process | glycerol-3-phosphate metabolic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| C | 0042803 | molecular_function | protein homodimerization activity |
| C | 0046168 | biological_process | glycerol-3-phosphate catabolic process |
| C | 0047952 | molecular_function | glycerol-3-phosphate dehydrogenase [NAD(P)+] activity |
| C | 0051287 | molecular_function | NAD binding |
| C | 0070062 | cellular_component | extracellular exosome |
| C | 0141152 | molecular_function | glycerol-3-phosphate dehydrogenase (NAD+) activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0005975 | biological_process | carbohydrate metabolic process |
| D | 0006072 | biological_process | glycerol-3-phosphate metabolic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| D | 0042803 | molecular_function | protein homodimerization activity |
| D | 0046168 | biological_process | glycerol-3-phosphate catabolic process |
| D | 0047952 | molecular_function | glycerol-3-phosphate dehydrogenase [NAD(P)+] activity |
| D | 0051287 | molecular_function | NAD binding |
| D | 0070062 | cellular_component | extracellular exosome |
| D | 0141152 | molecular_function | glycerol-3-phosphate dehydrogenase (NAD+) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | binding site for residue NAD A 401 |
| Chain | Residue |
| A | SER11 |
| A | PHE97 |
| A | ILE119 |
| A | LYS120 |
| A | ASN151 |
| A | ALA153 |
| A | ARG269 |
| A | GLN295 |
| A | LYS296 |
| A | GLN298 |
| A | 13P402 |
| A | GLY12 |
| A | HOH505 |
| A | HOH519 |
| A | HOH547 |
| A | HOH556 |
| A | HOH603 |
| A | ASN13 |
| A | TRP14 |
| A | GLY15 |
| A | PHE41 |
| A | TYR63 |
| A | VAL93 |
| A | PRO94 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | binding site for residue 13P A 402 |
| Chain | Residue |
| A | LYS120 |
| A | GLY149 |
| A | ASN151 |
| A | ILE152 |
| A | LYS204 |
| A | ASN205 |
| A | ASP260 |
| A | THR264 |
| A | GLY268 |
| A | ARG269 |
| A | ASN270 |
| A | NAD401 |
| A | HOH530 |
| A | HOH556 |
| A | HOH577 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 403 |
| Chain | Residue |
| A | VAL122 |
| A | ASP123 |
| A | GLU305 |
| A | HOH543 |
| A | HOH550 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue MPD A 404 |
| Chain | Residue |
| A | GLU163 |
| A | ARG187 |
| A | ILE188 |
| A | THR189 |
| C | HIS345 |
| C | PRO346 |
| site_id | AC5 |
| Number of Residues | 27 |
| Details | binding site for residue NAD B 401 |
| Chain | Residue |
| B | SER11 |
| B | GLY12 |
| B | ASN13 |
| B | TRP14 |
| B | GLY15 |
| B | PHE41 |
| B | TYR63 |
| B | VAL93 |
| B | PRO94 |
| B | PHE97 |
| B | ILE119 |
| B | LYS120 |
| B | ASN151 |
| B | ALA153 |
| B | ARG269 |
| B | GLY294 |
| B | GLN295 |
| B | LYS296 |
| B | GLN298 |
| B | 13P402 |
| B | HOH506 |
| B | HOH527 |
| B | HOH532 |
| B | HOH539 |
| B | HOH548 |
| B | HOH581 |
| B | HOH586 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | binding site for residue 13P B 402 |
| Chain | Residue |
| B | LYS120 |
| B | GLY149 |
| B | ASN151 |
| B | LYS204 |
| B | ASN205 |
| B | ASP260 |
| B | THR264 |
| B | GLY268 |
| B | ARG269 |
| B | ASN270 |
| B | NAD401 |
| B | HOH544 |
| B | HOH548 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue CA B 403 |
| Chain | Residue |
| B | VAL122 |
| B | ASP123 |
| B | GLU305 |
| B | HOH568 |
| B | HOH657 |
| site_id | AC8 |
| Number of Residues | 15 |
| Details | binding site for residue NAD C 401 |
| Chain | Residue |
| C | TRP39 |
| C | PHE41 |
| C | PHE97 |
| C | LEU118 |
| C | ILE119 |
| C | LYS120 |
| C | ASN151 |
| C | ALA153 |
| C | HOH505 |
| C | HOH605 |
| C | HOH626 |
| C | SER11 |
| C | GLY12 |
| C | ASN13 |
| C | TRP14 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue PO4 C 402 |
| Chain | Residue |
| C | GLU134 |
| C | ASP195 |
| C | PHE242 |
| C | SER244 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue PO4 D 401 |
| Chain | Residue |
| D | GLU134 |
| D | ASP195 |
| D | PHE242 |
| D | CYS243 |
| D | SER244 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue MPD D 402 |
| Chain | Residue |
| D | MET233 |
| D | GLU234 |
| D | LYS318 |
| D | HIS345 |
| D | GLU347 |
Functional Information from PROSITE/UniProt
| site_id | PS00957 |
| Number of Residues | 22 |
| Details | NAD_G3PDH NAD-dependent glycerol-3-phosphate dehydrogenase signature. GALKNVVAvGaGFcdGLgFGdN |
| Chain | Residue | Details |
| A | GLY201-ASN222 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 44 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16460752","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P13707","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"O35077","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
