6E7C

14-pf 3-start GMPCPP-human alpha1B/beta2B microtubules

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000278	biological_process	mitotic cell cycle
A	0003725	molecular_function	double-stranded RNA binding
A	0003924	molecular_function	GTPase activity
A	0005198	molecular_function	structural molecule activity
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0005881	cellular_component	cytoplasmic microtubule
A	0005929	cellular_component	cilium
A	0007017	biological_process	microtubule-based process
A	0015630	cellular_component	microtubule cytoskeleton
A	0016787	molecular_function	hydrolase activity
A	0030705	biological_process	cytoskeleton-dependent intracellular transport
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0051301	biological_process	cell division
A	0071353	biological_process	cellular response to interleukin-4
B	0000166	molecular_function	nucleotide binding
B	0000226	biological_process	microtubule cytoskeleton organization
B	0000278	biological_process	mitotic cell cycle
B	0001764	biological_process	neuron migration
B	0003924	molecular_function	GTPase activity
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0007017	biological_process	microtubule-based process
B	0007399	biological_process	nervous system development
B	0015630	cellular_component	microtubule cytoskeleton
B	0021987	biological_process	cerebral cortex development
B	0045171	cellular_component	intercellular bridge
B	0046872	molecular_function	metal ion binding
B	0046982	molecular_function	protein heterodimerization activity
B	0050804	biological_process	modulation of chemical synaptic transmission
B	0072686	cellular_component	mitotic spindle
B	0098685	cellular_component	Schaffer collateral - CA1 synapse
B	1902669	biological_process	positive regulation of axon guidance
B	1990403	biological_process	embryonic brain development

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue MG B 501

Chain	Residue
B	GLU69
B	G2P502

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site_id	AC2
Number of Residues	16
Details	binding site for residue G2P B 502

Chain	Residue
B	SER138
B	GLY141
B	GLY142
B	THR143
B	GLY144
B	GLU181
B	ASN204
B	TYR222
B	MG501
B	GLY10
B	GLN11
B	CYS12
B	GLN15
B	ASP67
B	GLY96
B	ASN99

---

site_id	AC3
Number of Residues	4
Details	binding site for residue MG A 501

Chain	Residue
A	GLN11
A	ASP69
A	GLU71
A	GTP502

---

site_id	AC4
Number of Residues	20
Details	binding site for residue GTP A 502

Chain	Residue
A	GLN11
A	GLN15
A	ASP69
A	GLU71
A	ASP98
A	ALA100
A	ASN101
A	SER140
A	GLY142
A	GLY143
A	THR145
A	ILE171
A	THR179
A	GLU183
A	ASN206
A	TYR224
A	LEU227
A	ASN228
A	MG501
B	LYS252

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Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
B	GLY140-GLY146
A	GLY142-GLY148

---

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
B	MET1-ILE4

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000269|PubMed:34996871

Chain	Residue	Details
A	GLU254
B	SER138
B	GLY142
B	THR143
B	GLY144
B	ASN204
B	ASN226

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:34996871, ECO:0000269|PubMed:35482892, ECO:0007744|PDB:7SJ7, ECO:0007744|PDB:7Z6S

Chain	Residue	Details
A	GLN11
A	GLU71
A	SER140
A	GLY144
A	THR145
A	THR179
A	ASN206
A	ASN228

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000269|PubMed:24906155

Chain	Residue	Details
A	LYS40

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000269|Ref.6

Chain	Residue	Details
A	SER48
A	SER232

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: 3'-nitrotyrosine => ECO:0000250|UniProtKB:P68373

Chain	Residue	Details
A	TYR282

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	MOD_RES: Omega-N-methylarginine => ECO:0000269|Ref.6

Chain	Residue	Details
A	ARG339

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site_id	SWS_FT_FI7
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Chain	Residue	Details
A	LYS326
B	THR290
A	LYS370

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Omega-N-methylarginine => ECO:0000250|UniProtKB:P07437

Chain	Residue	Details
B	ARG318

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site_id	SWS_FT_FI9
Number of Residues	1
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P07437

Chain	Residue	Details
B	LYS58

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site_id	SWS_FT_FI10
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P07437

Chain	Residue	Details
B	LYS324

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