6E6P
HRAS G13D bound to GppNHp (Ha,b,c13GNP)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005525 | molecular_function | GTP binding |
| A | 0007165 | biological_process | signal transduction |
| A | 0016020 | cellular_component | membrane |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005525 | molecular_function | GTP binding |
| B | 0007165 | biological_process | signal transduction |
| B | 0016020 | cellular_component | membrane |
| C | 0003924 | molecular_function | GTPase activity |
| C | 0005525 | molecular_function | GTP binding |
| C | 0007165 | biological_process | signal transduction |
| C | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 202 |
| Chain | Residue |
| A | SER17 |
| A | GNP201 |
| A | HOH313 |
| A | HOH321 |
| A | HOH347 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue CA A 203 |
| Chain | Residue |
| B | HOH341 |
| B | HOH349 |
| B | HOH362 |
| A | GLU3 |
| A | HOH351 |
| A | HOH354 |
| B | HOH309 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue GOL A 204 |
| Chain | Residue |
| A | GLY138 |
| A | ILE139 |
| A | GLU162 |
| A | GLN165 |
| A | HOH302 |
| C | GLU162 |
| site_id | AC4 |
| Number of Residues | 28 |
| Details | binding site for residue GNP B 201 |
| Chain | Residue |
| A | ARG41 |
| B | GLY12 |
| B | ASP13 |
| B | VAL14 |
| B | GLY15 |
| B | LYS16 |
| B | SER17 |
| B | ALA18 |
| B | PHE28 |
| B | VAL29 |
| B | ASP30 |
| B | GLY60 |
| B | ASN116 |
| B | LYS117 |
| B | ASP119 |
| B | LEU120 |
| B | SER145 |
| B | ALA146 |
| B | LYS147 |
| B | MG202 |
| B | HOH315 |
| B | HOH326 |
| B | HOH331 |
| B | HOH333 |
| B | HOH341 |
| B | HOH349 |
| B | HOH351 |
| B | HOH362 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 202 |
| Chain | Residue |
| B | SER17 |
| B | GNP201 |
| B | HOH315 |
| B | HOH326 |
| B | HOH351 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue GOL B 203 |
| Chain | Residue |
| B | PHE90 |
| B | GLU91 |
| B | ILE93 |
| B | HIS94 |
| B | LEU133 |
| C | ASN85 |
| C | LEU120 |
| C | ALA121 |
| site_id | AC7 |
| Number of Residues | 30 |
| Details | binding site for residue GNP C 201 |
| Chain | Residue |
| B | HOH355 |
| B | HOH361 |
| C | GLY12 |
| C | ASP13 |
| C | VAL14 |
| C | GLY15 |
| C | LYS16 |
| C | SER17 |
| C | ALA18 |
| C | PHE28 |
| C | VAL29 |
| C | ASP30 |
| C | TYR32 |
| C | PRO34 |
| C | THR35 |
| C | GLY60 |
| C | ASN116 |
| C | LYS117 |
| C | ASP119 |
| C | LEU120 |
| C | SER145 |
| C | ALA146 |
| C | LYS147 |
| C | MG202 |
| C | HOH317 |
| C | HOH322 |
| C | HOH325 |
| C | HOH346 |
| C | HOH348 |
| C | HOH349 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue MG C 202 |
| Chain | Residue |
| C | SER17 |
| C | THR35 |
| C | GNP201 |
| C | HOH317 |
| C | HOH325 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue CA C 203 |
| Chain | Residue |
| C | HOH367 |
| C | GLU3 |
| C | ASP33 |
| C | GLU76 |
| C | HOH327 |
| C | HOH331 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue NA C 204 |
| Chain | Residue |
| C | ASP13 |
| C | HOH322 |
| C | HOH348 |
| C | HOH373 |
| C | HOH375 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL C 205 |
| Chain | Residue |
| A | ASN85 |
| A | ALA122 |
| C | PHE90 |
| C | GLU91 |
| C | ILE93 |
| C | HIS94 |
| C | LEU133 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | Motif: {"description":"Effector region"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 50 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16698776","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35522713","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"N-acetylmethionine; in GTPase HRas; alternate","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"N-acetylthreonine; in GTPase HRas, N-terminally processed","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","Calvo F.","Kolch W."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"9020151","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL","evidences":[{"source":"PubMed","id":"19744486","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8626575","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8626586","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9632667","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
