6E6M

Crystal structure of human cellular retinol-binding protein 1 in complex with cannabidiorcin (CBDO)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002138	biological_process	retinoic acid biosynthetic process
A	0005501	molecular_function	retinoid binding
A	0005504	molecular_function	fatty acid binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005811	cellular_component	lipid droplet
A	0005829	cellular_component	cytosol
A	0006776	biological_process	vitamin A metabolic process
A	0008289	molecular_function	lipid binding
A	0015908	biological_process	fatty acid transport
A	0016918	molecular_function	retinal binding
A	0019841	molecular_function	retinol binding
A	0055088	biological_process	lipid homeostasis
A	1904768	molecular_function	all-trans-retinol binding
B	0002138	biological_process	retinoic acid biosynthetic process
B	0005501	molecular_function	retinoid binding
B	0005504	molecular_function	fatty acid binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005811	cellular_component	lipid droplet
B	0005829	cellular_component	cytosol
B	0006776	biological_process	vitamin A metabolic process
B	0008289	molecular_function	lipid binding
B	0015908	biological_process	fatty acid transport
B	0016918	molecular_function	retinal binding
B	0019841	molecular_function	retinol binding
B	0055088	biological_process	lipid homeostasis
B	1904768	molecular_function	all-trans-retinol binding
C	0002138	biological_process	retinoic acid biosynthetic process
C	0005501	molecular_function	retinoid binding
C	0005504	molecular_function	fatty acid binding
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005811	cellular_component	lipid droplet
C	0005829	cellular_component	cytosol
C	0006776	biological_process	vitamin A metabolic process
C	0008289	molecular_function	lipid binding
C	0015908	biological_process	fatty acid transport
C	0016918	molecular_function	retinal binding
C	0019841	molecular_function	retinol binding
C	0055088	biological_process	lipid homeostasis
C	1904768	molecular_function	all-trans-retinol binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue 8CB A 201

Chain	Residue
A	MET10
A	GLN128
A	ASN13
A	PHE16
A	ALA33
A	PRO38
A	SER55
A	ARG58
A	TYR60
A	GLY76

---

site_id	AC2
Number of Residues	11
Details	binding site for residue 8CB B 201

Chain	Residue
B	MET10
B	ASN13
B	PHE16
B	ALA33
B	LEU36
B	PRO38
B	SER55
B	ARG58
B	GLY76
B	GLN128
B	HOH321

---

site_id	AC3
Number of Residues	10
Details	binding site for residue 8CB C 201

Chain	Residue
C	MET10
C	ASN13
C	PHE16
C	ALA33
C	LEU36
C	PRO38
C	SER55
C	ARG58
C	GLY76
C	GLN128

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Functional Information from PROSITE/UniProt

site_id	PS00214
Number of Residues	18
Details	FABP Cytosolic fatty-acid binding proteins signature. GYWkMlvNeNFEeYLRAL

Chain	Residue	Details
A	GLY6-LEU23

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:26900151, ECO:0007744|PDB:5H8T, ECO:0007744|PDB:5HBS, ECO:0007744|PDB:5LJB, ECO:0007744|PDB:5LJC

Chain	Residue	Details
A	LYS40
B	LYS40
C	LYS40

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:28057518, ECO:0007744|PDB:5LJC, ECO:0007744|PDB:5LJE

Chain	Residue	Details
A	MET62
B	MET62
C	MET62

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:26900151, ECO:0000269|PubMed:28057518, ECO:0007744|PDB:5H8T, ECO:0007744|PDB:5HBS, ECO:0007744|PDB:5LJB, ECO:0007744|PDB:5LJC, ECO:0007744|PDB:5LJD, ECO:0007744|PDB:5LJE

Chain	Residue	Details
A	GLN108
B	GLN108
C	GLN108

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