6E6M
Crystal structure of human cellular retinol-binding protein 1 in complex with cannabidiorcin (CBDO)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002138 | biological_process | retinoic acid biosynthetic process |
| A | 0005501 | molecular_function | retinoid binding |
| A | 0005504 | molecular_function | fatty acid binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005811 | cellular_component | lipid droplet |
| A | 0005829 | cellular_component | cytosol |
| A | 0006776 | biological_process | vitamin A metabolic process |
| A | 0008289 | molecular_function | lipid binding |
| A | 0015908 | biological_process | fatty acid transport |
| A | 0016918 | molecular_function | retinal binding |
| A | 0019841 | molecular_function | retinol binding |
| A | 0055088 | biological_process | lipid homeostasis |
| A | 1904768 | molecular_function | all-trans-retinol binding |
| B | 0002138 | biological_process | retinoic acid biosynthetic process |
| B | 0005501 | molecular_function | retinoid binding |
| B | 0005504 | molecular_function | fatty acid binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005811 | cellular_component | lipid droplet |
| B | 0005829 | cellular_component | cytosol |
| B | 0006776 | biological_process | vitamin A metabolic process |
| B | 0008289 | molecular_function | lipid binding |
| B | 0015908 | biological_process | fatty acid transport |
| B | 0016918 | molecular_function | retinal binding |
| B | 0019841 | molecular_function | retinol binding |
| B | 0055088 | biological_process | lipid homeostasis |
| B | 1904768 | molecular_function | all-trans-retinol binding |
| C | 0002138 | biological_process | retinoic acid biosynthetic process |
| C | 0005501 | molecular_function | retinoid binding |
| C | 0005504 | molecular_function | fatty acid binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005654 | cellular_component | nucleoplasm |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005811 | cellular_component | lipid droplet |
| C | 0005829 | cellular_component | cytosol |
| C | 0006776 | biological_process | vitamin A metabolic process |
| C | 0008289 | molecular_function | lipid binding |
| C | 0015908 | biological_process | fatty acid transport |
| C | 0016918 | molecular_function | retinal binding |
| C | 0019841 | molecular_function | retinol binding |
| C | 0055088 | biological_process | lipid homeostasis |
| C | 1904768 | molecular_function | all-trans-retinol binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue 8CB A 201 |
| Chain | Residue |
| A | MET10 |
| A | GLN128 |
| A | ASN13 |
| A | PHE16 |
| A | ALA33 |
| A | PRO38 |
| A | SER55 |
| A | ARG58 |
| A | TYR60 |
| A | GLY76 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue 8CB B 201 |
| Chain | Residue |
| B | MET10 |
| B | ASN13 |
| B | PHE16 |
| B | ALA33 |
| B | LEU36 |
| B | PRO38 |
| B | SER55 |
| B | ARG58 |
| B | GLY76 |
| B | GLN128 |
| B | HOH321 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue 8CB C 201 |
| Chain | Residue |
| C | MET10 |
| C | ASN13 |
| C | PHE16 |
| C | ALA33 |
| C | LEU36 |
| C | PRO38 |
| C | SER55 |
| C | ARG58 |
| C | GLY76 |
| C | GLN128 |
Functional Information from PROSITE/UniProt
| site_id | PS00214 |
| Number of Residues | 18 |
| Details | FABP Cytosolic fatty-acid binding proteins signature. GYWkMlvNeNFEeYLRAL |
| Chain | Residue | Details |
| A | GLY6-LEU23 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 30 |
| Details | Region: {"description":"Important for interaction with STRA6","evidences":[{"source":"PubMed","id":"22665496","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26900151","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5H8T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HBS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LJB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LJC","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"28057518","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5LJC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LJE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26900151","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"28057518","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5H8T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HBS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LJB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LJC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LJD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LJE","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
